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Ligand · HZR

HZR · 1-butyl-3-chloranyl-4-(4-phenylpiperidin-1-yl)pyridin-2-one

HZR, 1-butyl-3-chloranyl-4-(4-phenylpiperidin-1-yl)pyridin-2-one (C20 H25 Cl N2 O, 344.9 g/mol), in the MolNFT structures on GenesisL1: bound in 4 records (3 PDB entries). Every binding site with its residues within 4.5 Å, the residues it…

Component
HZR
Formula
C20 H25 Cl N2 O
Class
ligand
Structures
4
PDB entries
3

Binding sites

HZR in 4 structures; the first of them:

  • 7E9G · Cryo-EM structure of Gi-bound metabotropic glutamate receptor mGlu2 · HZR R902 · binds LEU639, PHE643, TYR647, ARG724, MET728, LEU732, ASN735, ILE739 and 5 more
  • 8JD3 · Cryo-EM structure of Gi1-bound mGlu2-mGlu3 heterodimer · HZR 2901 · binds LEU639, GLY640, PHE643, TYR647, ASP725, ALA726, MET728, SER731 and 7 more
  • 8JD5 · Cryo-EM structure of Gi1-bound mGlu2-mGlu4 heterodimer · HZR 2901 · binds LEU639, PHE643, TYR647, ARG724, ASP725, MET728, SER731, LEU732 and 7 more
  • 7E9G · Cryo-EM structure of gi-bound metabotropic glutamate receptor MGLU2 · HZR R902 · binds LEU639, PHE643, TYR647, MET728, LEU732, ASN735, TRP773, LEU777 and 2 more

Residues it binds most

LEU 4, PHE 4, TYR 4, ASN 4, MET 4, SER 4, TRP 4, ILE 3, ARG 2, ASP 2 (residue and the binding sites it lines).

Found with

  • 40F · (1S,2S,5R,6S)-2-aminobicyclo[3.1.0]hexane-2,6-dicarboxylic acid
  • CLR · Cholesterol
  • GLU · Glutamic acid
  • PEF · Di-palmitoyl-3-sn-phosphatidylethanolamine
  • BQI · 5-methyl-N-(4-methylpyrimidin-2-yl)-4-(1H-pyrazol-4-yl)-1,3-thiazol-2-amine
  • NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose

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