UniProt P63096
Guanine nucleotide-binding protein G(i) subunit alpha-1 (P63096)
Guanine nucleotide-binding protein G(i) subunit alpha-1 (UniProt P63096): 313 experimental structures and 1 predicted model on GenesisL1, 7 ligands bound, 828 pockets. Binding sites, druggability and experiment against prediction…
- UniProt
- P63096
- Protein
- Guanine nucleotide-binding protein G(i) subunit alpha-1
- Experimental structures
- 313
- Predicted models
- 1
- Ligands
- 7
- Pockets
- 828 · 129 records with a druggable one
Structures
314 records of P63096 in the MolNFT archive: 313 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1KJY | Crystal Structure of Human G[alpha]i1 Bound to the GoLoco Motif of RGS14 | x-ray diffraction | A, C | — | — |
| 1KJY | Crystal structure of human G[ALPHA]I1 bound to the goloco motif of RGS14 | x-ray diffraction | A, C | — | — |
| 1Y3A | Structure of G-Alpha-I1 bound to a GDP-selective peptide provides insight into guanine nucleotide… | x-ray diffraction | A, B, C, D | — | — |
| 1Y3A | Structure of G-alpha-I1 bound to a GDP-selective peptide provides insight into guanine nucleotide… | x-ray diffraction | A, B, C, D | — | — |
| 2G83 | Structure of activated G-alpha-i1 bound to a nucleotide-state-selective peptide: Minimal… | x-ray diffraction | A, B | — | — |
| 2G83 | Structure of activated G-alpha-I1 bound to a nucleotide- state-selective peptide: minimal… | x-ray diffraction | A, B | — | — |
| 2GTP | Crystal structure of the heterodimeric complex of human RGS1 and activated Gi alpha 1 | x-ray diffraction | A, B | — | — |
| 2GTP | Crystal structure of the heterodimeric complex of human RGS1 and activated gi alpha 1 | x-ray diffraction | A, B | — | — |
| 2IK8 | Crystal structure of the heterodimeric complex of human RGS16 and activated Gi alpha 1 | x-ray diffraction | A, C | — | — |
| 2IK8 | Crystal structure of the heterodimeric complex of human RGS16 and activated gi alpha 1 | x-ray diffraction | A, C | — | — |
| 2OM2 | Crystal Structure Of Human G[alpha]i1 Bound To The Goloco Motif Of Rgs14 | x-ray diffraction | A, C | — | — |
| 2OM2 | Crystal structure of human G[ALPHA]I1 bound to the goloco motif of RGS14 | x-ray diffraction | A, C | — | — |
| 2XNS | Crystal Structure Of Human G alpha i1 Bound To A Designed Helical Peptide Derived From The Goloco… | x-ray diffraction | A, B | — | — |
| 2XNS | Crystal structure of human G alpha I1 bound to a designed helical peptide derived from the goloco… | x-ray diffraction | A, B | — | — |
| 3ONW | Structure of a G-alpha-i1 mutant with enhanced affinity for the RGS14 GoLoco motif. | x-ray diffraction | A, B | — | — |
| 3ONW | Structure of a G-alpha-I1 mutant with enhanced affinity for the RGS14 goloco motif. | x-ray diffraction | A, B | — | — |
| 3QE0 | A Galpha-i1 P-loop mutation prevents transition to the activated state | x-ray diffraction | A, B, C | — | — |
| 3QE0 | A galpha-I1 P-loop mutation prevents transition to the activated state | x-ray diffraction | A, B, C | — | — |
| 3QI2 | A Galpha P-loop mutation prevents transition to the activated state: G42R bound to RGS14 GoLoco | x-ray diffraction | A, B | — | — |
| 3QI2 | A galpha P-loop mutation prevents transition to the activated state: G42R bound to RGS14 goloco | x-ray diffraction | A, B | — | — |
| 3UMR | Crystal structure of the G202D mutant of human G-alpha-i1 | x-ray diffraction | A | — | — |
| 3UMR | Crystal structure of the G202D mutant of human G-alpha-I1 | x-ray diffraction | A | — | — |
| 3UMS | Crystal structure of the G202A mutant of human G-alpha-i1 | x-ray diffraction | A | — | — |
| 3UMS | Crystal structure of the G202A mutant of human G-alpha-I1 | x-ray diffraction | A | — | — |
| 4G5Q | Structure of LGN GL4/Galphai1 complex | x-ray diffraction | A, B, C, D | — | — |
| 4G5Q | Structure of lgn GL4/GALPHAI1 complex | x-ray diffraction | A, B, C, D | — | — |
| 5JS7 | Structural model of a apo G-protein alpha subunit determined with NMR residual dipolar couplings… | solution nmr | A | — | 3 (best 0.66) |
| 5JS7 | Structural model of a apo G-protein alpha subunit determined with NMR residual dipolar couplings… | solution nmr | A | — | — |
| 5JS8 | Structural Model of a Protein alpha subunit in complex with GDP obtained with SAXS and NMR residual… | solution nmr | A | — | — |
| 5JS8 | Structural model of a protein alpha subunit in complex with GDP obtained with saxs and NMR residual… | solution nmr | A | — | — |
| 5TDH | The crystal structure of the dominant negative mutant G protein ALPHA(I)-1-beta-1-gamma-2… | x-ray diffraction | A, H | GDP | — |
| 6CMO | Rhodopsin-Gi complex | electron microscopy | A | — | 9 (best 0.83) |
| 6CMO | Rhodopsin-gi complex | electron microscopy | A | — | — |
| 6CRK | Heterotrimeric G-protein in complex with an antibody fragment | x-ray diffraction | A | GDP | 6 (best 0.82) |
| 6CRK | Heterotrimeric G-protein in complex with an antibody fragment | x-ray diffraction | A | GDP | — |
| 6DDE | Mu opioid receptor-gi protein complex | electron microscopy | A | — | — |
| 6DDF | Mu Opioid Receptor-Gi Protein Complex | electron microscopy | A | — | 3 (best 0.82) |
| 6DDF | Mu opioid receptor-gi protein complex | electron microscopy | A | — | — |
| 6KPF | Cryo-EM structure of a class A GPCR with G protein complex | electron microscopy | A | — | — |
| 6KPF | Cryo-EM structure of a class a GPCR with G protein complex | electron microscopy | A | — | — |
| 6KPG | Cryo-EM structure of CB1-G protein complex | electron microscopy | A | — | — |
| 6KPG | Cryo-EM structure of CB1-G protein complex | electron microscopy | A | — | — |
| 6LFM | Cryo-EM structure of a class a GPCR | electron microscopy | A | — | — |
| 6LFO | Cryo-EM structure of a class A GPCR monomer | electron microscopy | A | — | — |
| 6LFO | Cryo-EM structure of a class a GPCR monomer | electron microscopy | A | — | — |
| 6LML | Cryo-EM structure of the human glucagon receptor in complex with GI1 | electron microscopy | A | — | — |
| 6N4B | Cannabinoid receptor 1-G protein complex | electron microscopy | A | — | — |
| 6OMM | Cryo-EM structure of formyl peptide receptor 2/LIPOXIN A4 receptor in complex with gi | electron microscopy | A | — | — |
| 6OS9 | human Neurotensin Receptor 1 (hNTSR1) - Gi1 Protein Complex in canonical conformation (C state) | electron microscopy | A | — | 6 (best 0.81) |
| 6OS9 | Human neurotensin receptor 1 (HNTSR1) - GI1 protein complex in canonical conformation (C state) | electron microscopy | A | — | — |
| 6OSA | Human neurotensin receptor 1 (HNTSR1) - GI1 protein complex in non- canonical conformation (nc… | electron microscopy | A | — | — |
| 6OT0 | Structure of human Smoothened-Gi complex | electron microscopy | A | — | — |
| 6OT0 | Structure of human smoothened-gi complex | electron microscopy | A | — | — |
| 6PB0 | Cryo-EM structure of urocortin 1-bound corticotropin-releasing factor 1 receptor in complex with gs… | electron microscopy | A | — | — |
| 6PB1 | Cryo-EM structure of urocortin 1-bound corticotropin-releasing factor 2 receptor in complex with gs… | electron microscopy | A | — | — |
| 6PT0 | Cryo-EM structure of human cannabinoid receptor 2-Gi protein in complex with agonist WIN 55,212-2 | electron microscopy | A | — | — |
| 6PT0 | Cryo-EM structure of human cannabinoid receptor 2-gi protein in complex with agonist win 55,212-2 | electron microscopy | A | — | — |
| 6QNO | Rhodopsin-gi protein complex | electron microscopy | A | — | — |
| 6VU8 | Structure of G-alpha-I bound to its chaperone ric-8A | electron microscopy | B | — | — |
| 6XBJ | Structure of human smo-D384R complex with gi | electron microscopy | A | — | — |
254 records more on the page itself.
Ligands
- J40 · [(2R)-1-[oxidanyl-[(2R,3R,5S,6R)-2,3,5,6-tetrakis(oxidanyl)-4-phosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-3-tetradecanoyloxy-propan-2-yl] (5E, 8E)-hexadeca-5,8,11,14-tetraenoate · in 7 records
- GDP · Guanosine-5'-diphosphate · in 5 records
- A1AEI · 4-methyl-N-[(2M)-2-(1H-tetrazol-5-yl)phenyl]-6-(trifluoromethyl)pyrimidin-2-amine · in 1 record
- A1D5Q · [(2~{R})-1-hexadecanoyloxy-3-[oxidanyl-[(2~{S},3~{R},5~{R},6~{S})-2,3,4,5,6-pentakis(oxidanyl)cyclohexyl]oxy-phosphoryl]oxy-propan-2-yl] (~{Z})-octadec-9-enoate · in 1 record
- FLF · 2-[[3-(trifluoromethyl)phenyl]amino] benzoic acid · in 1 record
- GOQ · 8-methoxy-6-nitro-naphtho[1,2-e][1,3]benzodioxole-5-carboxylic acid · in 1 record
- J5F · (1R,2R)-N-[(2S,3S)-2-azanyl-3-methyl-pentyl]-N-[4-(4-propylphenyl)phenyl]-2-pyridin-2-yl-cyclopropane-1-carboxamide · in 1 record
Experiment against prediction
- 2G83 chain A against the predicted model P63096: TM-score 0.99, RMSD 0.58 Å
- 2G83 chain A against the predicted model P63096: TM-score 0.99, RMSD 0.58 Å
- 2IK8 chain C against the predicted model P63096: TM-score 0.99, RMSD 0.63 Å
- 2IK8 chain C against the predicted model P63096: TM-score 0.99, RMSD 0.63 Å
- 2IK8 chain A against the predicted model P63096: TM-score 0.99, RMSD 0.69 Å
- 2IK8 chain A against the predicted model P63096: TM-score 0.99, RMSD 0.69 Å
- 2GTP chain B against the predicted model P63096: TM-score 0.99, RMSD 0.72 Å
- 2GTP chain B against the predicted model P63096: TM-score 0.99, RMSD 0.72 Å
- 2GTP chain A against the predicted model P63096: TM-score 0.99, RMSD 0.71 Å
- 2GTP chain A against the predicted model P63096: TM-score 0.99, RMSD 0.71 Å
Elsewhere
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