GL1X · GenesisL1 explorer

Ligand · T7M

T7M · (2R)-1-(heptadecanoyloxy)-3-{[(R)-hydroxy{[(1R,2R,3R,4R,5S,6R)-2,3,5,6-tetrahydroxy-4-(phosphonooxy)cyclohexyl]oxy}phosphoryl]oxy}propan-2-yl (5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraenoate

T7M, (2R)-1-(heptadecanoyloxy)-3-{[(R)-hydroxy{[(1R,2R,3R,4R,5S,6R)-2,3,5,6-tetrahydroxy-4-(phosphonooxy)cyclohexyl]oxy}phosphoryl]oxy}propan-2-yl (5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraenoate (C46 H82 O16 P2, 953.1 g/mol), in the MolNFT…

Component
T7M
Formula
C46 H82 O16 P2
Class
ligand
Structures
4
PDB entries
3

Binding sites

T7M in 4 structures; the first of them:

  • 3SPW · Structure of Osh4p/Kes1p in complex with phosphatidylinositol 4-phosphate · T7M A435 · binds LEU24, SER25, SER26, LEU27, SER28, ALA29, ILE33, LEU34 and 21 more
  • 8PJK · ST171-bound serotonin 5-HT1A receptor - Gi Protein Complex · T7M R504 · binds ASP350, CYS351, GLY352, ARG134, LYS342, LYS345, THR346, ILE349 and 7 more
  • 8PKM · Befiradol-bound serotonin 5-HT1A receptor - Gi Protein Complex · T7M R502 · binds ASP350, CYS351, GLY352, ILE75, ARG134, LYS342, LYS345, THR346 and 6 more
  • 3SPW · Structure of OSH4P/KES1P in complex with phosphatidylinositol 4- phosphate · T7M A435 · binds LEU24, SER25, SER26, LEU27, SER28, ALA29, ILE33, LEU34 and 21 more

Residues it binds most

LEU 4, LYS 6, SER 4, ILE 4, ASN 6, HIS 4, ALA 4, ARG 6, GLU 4, PHE 4 (residue and the binding sites it lines).

Found with

  • CLR · Cholesterol
  • ZKV · (3-chloranyl-4-fluoranyl-phenyl)-[4-fluoranyl-4-[[(5-methylpyridin-2-yl)methylamino]methyl]piperidin-1-yl]methanone
  • ZL9 · 6-[3-[2-(2-methoxyphenoxy)ethylamino]propoxy]-4~{H}-1,4-benzoxazin-3-one

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