MolNFT v1 · #177654 · protein

Cryo-EM structure of inactive MGLU2 homodimer

7EPA · Metabotropic glutamate receptor 2: “Cryo-EM structure of inactive MGLU2 homodimer”. Electron microscopy, 18 pockets (best druggability 0.83). MolNFT v1 #177654 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 7EPA
Type: protein
Length: 1,564 residues
Chains: 2
Method: electron microscopy
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Metabotropic glutamate receptor 2
UniProt: Q14416
Pockets: 18 · best druggability 0.83

Structure

electron microscopy · 1 distinct chain · 43% helix, 11% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B	Metabotropic glutamate receptor 2	protein	782	43% helix, 11% strand	Q14416

Pockets

18 pockets found on a 1 Å grid, 9 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	1083	0.83	0.84	124	empty
2	708	0.82	0.86	98	empty
3	988	0.75	0.78	87	empty
4	78	0.72	0.96	19	empty
5	764	0.71	0.77	87	empty

Interfaces

1 interface between chains.

A–B · 1270 Å² buried · 5 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 19 disulfide (disulfide).

Compared structures

7EPA · Cryo-EM structure of inactive mGlu2 homodimer · the same entry in another collection · chain A against A, TM-score 1.00
Q14416 · AlphaFold monomer V2.0 prediction for metabotropic glutamate receptor 2 (Q14416) · a predicted model of the same protein · chain A against A, TM-score 0.72

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q14416
Elsewhere: RCSB PDB 7EPA · PDBe 7EPA · UniProt Q14416

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