MolNFT v1 · #182518 · protein
Cryoem structure of full-length MGLU2 in inactive-state bound to antagonist LY341495
7MTQ: “Cryoem structure of full-length MGLU2 in inactive-state bound to antagonist LY341495”. Electron microscopy, 2 ligands (Z99, NAG). MolNFT v1 #182518 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 7MTQ
- Type
- protein
- Length
- 1,486 residues
- Chains
- 2
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- UniProt
- Q14416
- Ligands
- Z99, NAG
Structure
electron microscopy · 2 distinct chains.
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | — | protein | 742 | — | Q14416 |
| B | — | protein | 744 | — | Q14416 |
Ligands and binding sites
- Z99 · 2-[(1S,2S)-2-carboxycyclopropyl]-3-(9H-xanthen-9-yl)-D-alanine · ligand · 2 copies · chains A, B
- NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · sugar · 2 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Compared structures
- 7MTQ · CryoEM Structure of Full-Length mGlu2 in Inactive-State Bound to Antagonist LY341495 · the same entry in another collection · chain A against A, TM-score 1.00
- Q14416 · AlphaFold monomer V2.0 prediction for metabotropic glutamate receptor 2 (Q14416) · a predicted model of the same protein · chain A against A, TM-score 0.78
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q14416
- Elsewhere: RCSB PDB 7MTQ · PDBe 7MTQ · UniProt Q14416
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