Research workbench
Cryoem structure of full-length MGLU2 in inactive-state bound to antagonist LY341495
Analyse Cryoem structure of full-length MGLU2 in inactive-state bound to antagonist… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 7MTQ
- Type
- protein
- Length
- 1,486 residues
- Chains
- 2
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Metabotropic glutamate receptor 2
- UniProt
- Q14416
- Ligands
- Z99, NAG
- Pockets
- 13 · best druggability 0.84
Structure
electron microscopy · 2 distinct chains · 46% helix, 11% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Metabotropic glutamate receptor 2 | protein | 742 | 46% helix, 11% strand | Q14416 |
| B | Metabotropic glutamate receptor 2 | protein | 744 | 45% helix, 11% strand | Q14416 |
Ligands and binding sites
- Z99 · 2-[(1S,2S)-2-carboxycyclopropyl]-3-(9H-xanthen-9-yl)-D-alanine · ligand · 2 copies · chains A, B
- NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · sugar · 2 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
13 pockets found on a 1 Å grid, 8 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1174 | 0.84 | 0.85 | 128 | empty |
| 2 | 742 | 0.79 | 0.83 | 75 | empty |
| 3 | 945 | 0.76 | 0.78 | 79 | empty |
| 4 | 462 | 0.63 | 0.76 | 43 | Z99 |
| 5 | 110 | 0.62 | 0.87 | 23 | empty |
Interfaces
1 interface between chains.
- A–B · 728 Ų buried · 3 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 10 disulfide, 2 glycan (disulfide, N-glycosylation).
Compared structures
- 7MTQ · CryoEM Structure of Full-Length mGlu2 in Inactive-State Bound to Antagonist LY341495 · the same entry in another collection · chain A against A, TM-score 1.00
- Q14416 · AlphaFold monomer V2.0 prediction for metabotropic glutamate receptor 2 (Q14416) · a predicted model of the same protein · chain A against A, TM-score 0.78
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q14416
- Elsewhere: RCSB PDB 7MTQ · PDBe 7MTQ · UniProt Q14416
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