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Ligand · Z99

Z99 · 2-[(1S,2S)-2-carboxycyclopropyl]-3-(9H-xanthen-9-yl)-D-alanine

Z99, 2-[(1S,2S)-2-carboxycyclopropyl]-3-(9H-xanthen-9-yl)-D-alanine (C20 H19 N O5, 353.4 g/mol), in the MolNFT structures on GenesisL1: bound in 10 records (8 PDB entries). Every binding site with its residues within 4.5 Å, the residues it…

Component
Z99
Formula
C20 H19 N O5
Class
ligand
Structures
10
PDB entries
8

Binding sites

Z99 in 10 structures; the first of them:

  • 7MTQ · CryoEM Structure of Full-Length mGlu2 in Inactive-State Bound to Antagonist LY341495 · Z99 A902 · binds ARG57, ARG61, SER143, TYR144, SER145, ALA166, SER167, THR168 and 5 more
  • 7WI6 · Cryo-EM structure of LY341495/NAM-bound mGlu3 · Z99 A901 · binds ARG64, ARG68, SER149, TYR150, SER151, ALA172, SER173, THR174 and 5 more
  • 8JCU · Cryo-EM structure of mGlu2-mGlu3 heterodimer in presence of LY341495 (dimerization mode I) · Z99 21101 · binds ARG57, ARG61, SER143, TYR144, SER145, ALA166, SER167, THR168 and 6 more
  • 8JCX · Cryo-EM structure of mGlu2-mGlu3 heterodimer in presence of LY341495 and NAM563… · Z99 21102 · binds ARG57, ARG61, SER143, TYR144, SER145, ALA166, SER167, THR168 and 6 more
  • 8TR0 · Metabotropic glutamate receptor 3 class 3 bound to antagonist LY 341495 · Z99 A1001 · binds ARG64, ARG68, SER149, TYR150, SER151, ALA172, SER173, THR174 and 8 more
  • 8TRD · mGluR3 class 1 in the presence of the antagonist LY 341495 · Z99 A1001 · binds ARG64, ARG68, SER149, TYR150, SER151, ALA172, SER173, THR174 and 8 more
  • 7FD9 · Thermostabilised full length human MGLUR5-5M with orthosteric antagonist, LY341495 · Z99 A902 · binds TYR64, TRP100, GLY150, SER151, SER152, SER173, ALA174, THR175 and 3 more
  • 7MTQ · Cryoem structure of full-length MGLU2 in inactive-state bound to antagonist LY341495 · Z99 A902 · binds ARG57, ARG61, SER143, TYR144, SER145, ALA166, SER167, THR168 and 5 more
  • 7WI6 · Cryo-EM structure of LY341495/NAM-bound MGLU3 · Z99 A901 · binds ARG64, ARG68, TYR150, SER151, ALA172, SER173, THR174, TYR222 and 1 more
  • 7WI8 · Cryo-EM structure of inactive MGLU3 bound to LY341495 · Z99 A902 · binds ARG64, ARG68, SER149, TYR150, SER151, ALA172, THR174, TYR222

Residues it binds most

SER 20, ARG 18, TYR 20, ASP 16, ALA 20, THR 20, LYS 15, GLY 7, GLU 4, TRP 2 (residue and the binding sites it lines).

Found with

  • NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose

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