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Ligand · ZQY

ZQY · 2-methoxy-6-propyl-N-(2-{4-[(1H-tetrazol-5-yl) methoxy]phenyl}ethyl)thieno[2,3-d]pyrimidin-4-amine

ZQY, 2-methoxy-6-propyl-N-(2-{4-[(1H-tetrazol-5-yl) methoxy]phenyl}ethyl)thieno[2,3-d]pyrimidin-4-amine (C20 H23 N7 O2 S, 425.5 g/mol), in the MolNFT structures on GenesisL1: bound in 4 records (2 PDB entries). Every binding site with its…

Component
ZQY
Formula
C20 H23 N7 O2 S
Class
ligand
Structures
4
PDB entries
2

Binding sites

ZQY in 4 structures; the first of them:

  • 7MTR · CryoEM Structure of Full-Length mGlu2 Bound to Ago-PAM ADX55164 and Glutamate · ZQY A903 · binds GLY640, PHE643, ARG724, MET728, SER731, LEU732, ASN735, CYS770 and 1 more
  • 7MTS · CryoEM Structure of mGlu2 - Gi Complex · ZQY A901 · binds PHE623, LEU639, GLY640, PHE643, ARG724, MET728, SER731, LEU732 and 7 more
  • 7MTR · Cryoem structure of full-length MGLU2 bound to ago-pam ADX55164 and glutamate · ZQY A903 · binds GLY640, PHE643, ARG724, MET728, SER731, LEU732, ASN735, CYS770 and 1 more
  • 7MTS · Cryoem structure of MGLU2 - gi complex · ZQY A901 · binds PHE623, LEU639, GLY640, PHE643, ARG724, MET728, SER731, LEU732 and 5 more

Residues it binds most

PHE 4, LEU 4, MET 4, ARG 4, ASN 4, GLY 4, SER 4, TRP 4, CYS 3, ILE 2 (residue and the binding sites it lines).

Found with

  • NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose
  • GLU · Glutamic acid

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