MolNFT v2 · #224041 · protein
mGlu2-4 inactive heterodimer
8WGD · Metabotropic glutamate receptor 2: “mGlu2-4 inactive heterodimer”. Electron microscopy at 4.45, 2 ligands (WAG, WA6), 12 pockets (best druggability 0.74). MolNFT v2 #224041 on GenesisL1: 3D structure, binding sites and pockets in…
- PDB
- 8WGD
- Type
- protein
- Length
- 1,508 residues
- Chains
- 2
- Method
- electron microscopy
- Collection
- MolNFT v2 / PDB Bank
- Contract
- 0xd58B01f6C18086e5202cdC5D7Ad3E41790360102
- Owner
- 0xF4e1AA6f26B7DA48EeAD9B24a97927303eeA07b8
- Resolution
- 4.45
- Source
- Homo sapiens
- Molecule
- Metabotropic glutamate receptor 2; Metabotropic glutamate receptor 4
- UniProt
- Q14416, Q14833
- Ligands
- WAG, WA6
- Pockets
- 12 · best druggability 0.74
Structure
electron microscopy · resolution 4.45 · 2 distinct chains · 47% helix, 16% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| C | Metabotropic glutamate receptor 2 | protein | 756 | 46% helix, 13% strand | Q14416 |
| B | Metabotropic glutamate receptor 4 | protein | 752 | 47% helix, 18% strand | Q14833 |
Ligands and binding sites
- WAG · (1S,2R)-2-[(2S)-2-azanyl-1-oxidanyl-1-oxidanylidene-3-(9H-xanthen-9-yl)propan-2-yl]cyclopropane-1-carboxylic acid · ligand · chains C
- WA6 · (2S)-2-azanyl-2-cyclopropyl-2-(4-phosphonophenyl)ethanoic acid · ligand · chains B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
12 pockets found on a 1 Å grid, 10 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1081 | 0.74 | 0.78 | 118 | empty |
| 2 | 807 | 0.72 | 0.78 | 78 | empty |
| 3 | 723 | 0.72 | 0.79 | 74 | empty |
| 4 | 732 | 0.70 | 0.78 | 91 | empty |
| 5 | 793 | 0.69 | 0.76 | 83 | empty |
Compared structures
- Q14416 · AlphaFold monomer V2.0 prediction for metabotropic glutamate receptor 2 (Q14416) · a predicted model of the same protein · chain C against A, TM-score 0.74
- Q14833 · AlphaFold monomer V2.0 prediction for metabotropic glutamate receptor 4 (Q14833) · a predicted model of the same protein · chain B against A, TM-score 0.71
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q14416
- Every structure of UniProt Q14833
- Elsewhere: RCSB PDB 8WGD · PDBe 8WGD · UniProt Q14416 · UniProt Q14833
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