UniProt Q14833
Metabotropic glutamate receptor 4 (Q14833)
Metabotropic glutamate receptor 4 (UniProt Q14833), EC 2.7.11.1: 9 experimental structures and 1 predicted model on GenesisL1, 10 ligands bound, 84 pockets. Binding sites, druggability and experiment against prediction (TM-score)…
- UniProt
- Q14833
- Protein
- Metabotropic glutamate receptor 4
- EC
- 2.7.11.1
- Experimental structures
- 9
- Predicted models
- 1
- Ligands
- 10
- Pockets
- 84 · 9 records with a druggable one
Structures
10 records of Q14833 in the MolNFT archive: 9 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 7E9H | Cryo-EM structure of Gi-bound metabotropic glutamate receptor mGlu4 | electron microscopy | R, S | SEP | 11 (best 0.86) |
| 7E9H | Cryo-EM structure of gi-bound metabotropic glutamate receptor MGLU4 | electron microscopy | R, S | — | — |
| 8JD4 | Cryo-EM structure of G protein-free mGlu2-mGlu4 heterodimer in Acc state | electron microscopy | 4 | GLU, NAG | 11 (best 0.81) |
| 8JD5 | Cryo-EM structure of Gi1-bound mGlu2-mGlu4 heterodimer | electron microscopy | 4 | CLR, PEF, GLU, NAG, BQI | 9 (best 0.80) |
| 8JD6 | Cryo-EM structure of Gi1-bound metabotropic glutamate receptor mGlu4 | electron microscopy | S, R | BK0, SEP | 14 (best 0.83) |
| 8WG9 | mGlu2-mGlu4 heterodimer bound mGlu4 agonist E7P | electron microscopy | B | E7P | 9 (best 0.83) |
| 8WGB | mGlu2-4 heterodimer bound with Gi | electron microscopy | R | GLU, W9R | 10 (best 0.81) |
| 8WGC | heterodimer of mGlu2 and mGlu4 bound with mGlu2 agonist LY379268 | electron microscopy | A | — | 6 (best 0.73) |
| 8WGD | mGlu2-4 inactive heterodimer | electron microscopy | B | WA6 | 6 (best 0.72) |
| Q14833 | AlphaFold monomer V2.0 prediction for metabotropic glutamate receptor 4 (Q14833) | predicted | A | — | 8 (best 0.72) |
Ligands
- GLU · Glutamic acid · in 3 records
- NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · in 2 records
- SEP · Phosphoserine · in 2 records
- BK0 · N-(3-chlorophenyl)pyridine-2-carboxamide · in 1 record
- BQI · 5-methyl-N-(4-methylpyrimidin-2-yl)-4-(1H-pyrazol-4-yl)-1,3-thiazol-2-amine · in 1 record
- CLR · Cholesterol · in 1 record
- E7P · (2S)-2-amino-4-phosphonobutanoic acid · in 1 record
- PEF · Di-palmitoyl-3-sn-phosphatidylethanolamine · in 1 record
- W9R · (1R,2S)-2-[[3,5-bis(chloranyl)phenyl]carbamoyl]cyclohexane-1-carboxylic acid · in 1 record
- WA6 · (2S)-2-azanyl-2-cyclopropyl-2-(4-phosphonophenyl)ethanoic acid · in 1 record
Experiment against prediction
- 8WGB chain R against the predicted model Q14833: TM-score 0.93, RMSD 2.62 Å
- 8JD4 chain 4 against the predicted model Q14833: TM-score 0.92, RMSD 2.90 Å
- 8JD5 chain 4 against the predicted model Q14833: TM-score 0.90, RMSD 3.26 Å
- 8JD6 chain S against the predicted model Q14833: TM-score 0.89, RMSD 3.40 Å
- 8JD6 chain R against the predicted model Q14833: TM-score 0.88, RMSD 3.69 Å
- 7E9H chain R against the predicted model Q14833: TM-score 0.87, RMSD 3.82 Å
- 7E9H chain R against the predicted model Q14833: TM-score 0.87, RMSD 3.82 Å
- 7E9H chain S against the predicted model Q14833: TM-score 0.86, RMSD 3.90 Å
- 7E9H chain S against the predicted model Q14833: TM-score 0.86, RMSD 3.90 Å
- 8WG9 chain B against the predicted model Q14833: TM-score 0.86, RMSD 4.06 Å
Elsewhere
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