UniProt P48736
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform (P48736)
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform (UniProt P48736), EC 2.7.1.153, 2.7.11.1: 194 experimental structures on GenesisL1, 18 ligands bound, 46 pockets. Binding sites, pockets, druggability…
- UniProt
- P48736
- Protein
- Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
- EC
- 2.7.1.153, 2.7.11.1
- Experimental structures
- 194
- Predicted models
- 0
- Ligands
- 18
- Pockets
- 46 · 3 records with a druggable one
Structures
194 records of P48736 in the MolNFT archive: 194 experimental, 0 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1E8Y | Structure determinants of phosphoinositide 3-kinase inhibition by wortmannin, LY294002, quercetin… | x-ray diffraction | A | — | — |
| 1E8Y | Structure determinants of phosphoinositide 3-kinase inhibition by wortmannin, LY294002, quercetin… | x-ray diffraction | A | — | — |
| 1E8Z | Structure determinants of phosphoinositide 3-kinase inhibition by wortmannin, LY294002, quercetin… | x-ray diffraction | A | — | — |
| 1E8Z | Structure determinants of phosphoinositide 3-kinase inhibition by wortmannin, LY294002, quercetin… | x-ray diffraction | A | — | — |
| 1HE8 | Ras G12V - PI 3-kinase gamma complex | x-ray diffraction | A | — | — |
| 1HE8 | RAS G12V - pi 3-kinase gamma complex | x-ray diffraction | A | — | — |
| 2A4Z | Crystal Structure of human PI3Kgamma complexed with AS604850 | x-ray diffraction | A | — | — |
| 2A4Z | Crystal structure of human PI3KGAMMA complexed with AS604850 | x-ray diffraction | A | — | — |
| 2A5U | Crystal Structure of human PI3Kgamma complexed with AS605240 | x-ray diffraction | A | — | — |
| 2A5U | Crystal structure of human PI3KGAMMA complexed with AS605240 | x-ray diffraction | A | — | — |
| 2CHW | A pharmacological map of the PI3-K family defines a role for p110 alpha in signaling: The structure… | x-ray diffraction | A | — | — |
| 2CHW | A pharmacological MAP of the PI3-K family defines a role for P110 alpha in signaling: the structure… | x-ray diffraction | A | — | — |
| 2CHX | A pharmacological map of the PI3-K family defines a role for p110alpha in signaling: The structure… | x-ray diffraction | A | — | — |
| 2CHX | A pharmacological MAP of the PI3-K family defines a role for P110ALPHA in signaling: the structure… | x-ray diffraction | A | — | — |
| 2CHZ | A pharmacological map of the PI3-K family defines a role for p110alpha in signaling: The structure… | x-ray diffraction | A | — | — |
| 2CHZ | A pharmacological MAP of the PI3-K family defines a role for P110ALPHA in signaling: the structure… | x-ray diffraction | A | — | — |
| 2V4L | complex of human phosphoinositide 3-kinase catalytic subunit gamma (p110 gamma) with PIK-284 | x-ray diffraction | A | — | — |
| 2V4L | Complex of human phosphoinositide 3-kinase catalytic subunit gamma (P110 gamma) with pik-284 | x-ray diffraction | A | — | — |
| 3APC | Crystal structure of human PI3K-gamma in complex with CH5132799 | x-ray diffraction | A | — | — |
| 3APC | Crystal structure of human PI3K-gamma in complex with CH5132799 | x-ray diffraction | A | — | — |
| 3APD | Crystal structure of human PI3K-gamma in complex with CH5108134 | x-ray diffraction | A | — | — |
| 3APD | Crystal structure of human PI3K-gamma in complex with CH5108134 | x-ray diffraction | A | — | — |
| 3APF | Crystal structure of human PI3K-gamma in complex with CH5039699 | x-ray diffraction | A | — | — |
| 3APF | Crystal structure of human PI3K-gamma in complex with CH5039699 | x-ray diffraction | A | — | — |
| 3CSF | Crystal structure of PI3K p110gamma catalytical domain in complex with organoruthenium inhibitor DW2 | x-ray diffraction | A | — | — |
| 3CSF | Crystal structure of PI3K P110GAMMA catalytical domain in complex with organoruthenium inhibitor DW2 | x-ray diffraction | A | — | — |
| 3CST | Crystal structure of PI3K p110gamma catalytical domain in complex with organoruthenium inhibitor… | x-ray diffraction | A | — | — |
| 3CST | Crystal structure of PI3K P110GAMMA catalytical domain in complex with organoruthenium inhibitor… | x-ray diffraction | A | — | — |
| 3DBS | Structure of PI3K gamma in complex with GDC0941 | x-ray diffraction | A | — | — |
| 3DBS | Structure of PI3K gamma in complex with GDC0941 | x-ray diffraction | A | — | — |
| 3DPD | Achieving multi-isoform PI3K inhibition in a series of substituted 3,4-Dihydro-2H-benzo[1,4]oxazines | x-ray diffraction | A | — | — |
| 3DPD | Achieving multi-isoform PI3K inhibition in a series of substituted 3,4-dihydro-2H-BENZO[1,4]OXAZINES | x-ray diffraction | A | — | — |
| 3ENE | Complex of PI3K gamma with an inhibitor | x-ray diffraction | A | — | — |
| 3ENE | Complex of PI3K gamma with an inhibitor | x-ray diffraction | A | — | — |
| 3IBE | Crystal Structure of a Pyrazolopyrimidine Inhibitor Bound to PI3 Kinase Gamma | x-ray diffraction | A | — | — |
| 3IBE | Crystal structure of a pyrazolopyrimidine inhibitor bound to PI3 kinase gamma | x-ray diffraction | A | — | — |
| 3L08 | Structure of Pi3K gamma with a potent inhibitor: GSK2126458 | x-ray diffraction | A | — | — |
| 3L08 | Structure of PI3K gamma with a potent inhibitor: GSK2126458 | x-ray diffraction | A | — | — |
| 3L13 | Crystal Structures of Pan-PI3-Kinase and Dual Pan-PI3-Kinase/mTOR Inhibitors | x-ray diffraction | A | — | — |
| 3L13 | Crystal structures of pan-PI3-kinase and dual pan-PI3-KINASE/MTOR inhibitors | x-ray diffraction | A | — | — |
| 3L16 | Discovery of (thienopyrimidin-2-yl)aminopyrimidines as Potent, Selective, and Orally Available… | x-ray diffraction | A | — | — |
| 3L16 | Discovery of (thienopyrimidin-2-YL)AMINOPYRIMIDINES as potent, selective, and orally available… | x-ray diffraction | A | — | — |
| 3L17 | Discovery of (thienopyrimidin-2-yl)aminopyrimidines as Potent, Selective, and Orally Available… | x-ray diffraction | A | — | — |
| 3L17 | Discovery of (thienopyrimidin-2-YL)AMINOPYRIMIDINES as potent, selective, and orally available… | x-ray diffraction | A | — | — |
| 3L54 | Structure of Pi3K gamma with inhibitor | x-ray diffraction | A | — | — |
| 3L54 | Structure of PI3K gamma with inhibitor | x-ray diffraction | A | — | — |
| 3LJ3 | PI3-kinase-gamma with a pyrrolopyridine-benzofuran inhibitor | x-ray diffraction | A | — | — |
| 3LJ3 | PI3-kinase-gamma with a pyrrolopyridine-benzofuran inhibitor | x-ray diffraction | A | — | — |
| 3MJW | PI3 Kinase gamma with a benzofura inhibitor | x-ray diffraction | A | — | — |
| 3MJW | PI3 kinase gamma with a benzofuranone inhibitor | x-ray diffraction | A | — | — |
| 3ML8 | Discovery of the Highly Potent PI3K/mTOR Dual Inhibitor PF-04691502 through Structure Based Drug… | x-ray diffraction | A | — | — |
| 3ML8 | Discovery of the highly potent PI3K/MTOR dual inhibitor pf-04691502 through structure based drug… | x-ray diffraction | A | — | — |
| 3ML9 | Discovery of the Highly Potent PI3K/mTOR Dual Inhibitor PF-04691502 through Structure Based Drug… | x-ray diffraction | A | — | — |
| 3ML9 | Discovery of the highly potent PI3K/MTOR dual inhibitor pf-04691502 through structure based drug… | x-ray diffraction | A | — | — |
| 3NZS | Structure-based Optimization of Pyrazolo -Pyrimidine and -Pyridine Inhibitors of PI3-Kinase | x-ray diffraction | A | — | — |
| 3NZS | Structure-based optimization of pyrazolo -pyrimidine and -pyridine inhibitors of PI3-kinase | x-ray diffraction | A | — | — |
| 3NZU | Structure-based Optimization of Pyrazolo -Pyrimidine and -Pyridine Inhibitors of PI3-Kinase | x-ray diffraction | A | — | — |
| 3NZU | Structure-based optimization of pyrazolo -pyrimidine and -pyridine inhibitors of PI3-kinase | x-ray diffraction | A | — | — |
| 3OAW | 4-Methylpteridineones as Orally Active and Selective PI3K/mTOR Dual Inhibitors | x-ray diffraction | A | — | — |
| 3OAW | 4-methylpteridineones as orally active and selective PI3K/MTOR dual inhibitors | x-ray diffraction | A | — | — |
134 records more on the page itself.
Ligands
- SO4 · Sulfate ion · in 10 records
- DD8 · 3-methyl-1-(oxan-4-yl)-8-pyridin-3-yl-imidazo[4,5-c]quinolin-2-one · in 3 records
- V7Y · 2-amino-N-[(1S)-1-{8-[(1-methyl-1H-pyrazol-4-yl) ethynyl]-1-oxo-2-phenyl-1,2-dihydroisoquinolin-3-yl}ethyl]pyrazolo[1,5-a]pyrimidine-3-carboxamide · in 3 records
- 6RF · 4-azanyl-6-[[(1~{S})-1-(6-fluoranyl-3-phenyl-4-piperazin-1-ylcarbonyl-quinolin-2-yl) ethyl]amino]pyrimidine-5-carbonitrile · in 2 records
- A3W · 5-(4,6-dimorpholin-4-yl-1,3,5-triazin-2-yl)-4-(trifluoromethyl)pyridin-2-amine · in 2 records
- M9T · 2-[(4-methoxy-2-methyl-phenyl)amino]-7-methyl-9-(4-oxidanylcyclohexyl)purin-8-one · in 2 records
- 5MT · 4-azanyl-6-[[(1~{S})-1-[6-fluoranyl-1-(3-methylsulfonylphenyl)benzimidazol-2-yl]ethyl]amino]pyrimidine-5-carbonitrile · in 1 record
- 6E2 · 2-azanyl-~{N}-[7-methoxy-8-(3-morpholin-4-ylpropoxy)-2,3-dihydroimidazo[1,2-c]quinazolin-5-yl]pyrimidine-5-carboxamide · in 1 record
- 6K7 · [1-{4-[6-amino-4-(trifluoromethyl)pyridin-3-yl]-6-(morpholin-4-yl)pyrimidin-2-yl}-3-(chloromethyl)azetidin-3-yl]methanol · in 1 record
- 74F · 3-(benzotriazol-1-yl)-5-[1-methyl-5-[(1~{S})-1-morpholin-4-ylethyl]-1,2,4-triazol-3-yl]pyrazin-2-amine · in 1 record
- BWY · 10-[(S)-(1-tert-butylpiperidin-4-yl)sulfinyl]-2-[1-(propan-2-yl)-1H-1,2,4-triazol-5-yl]-5,6-dihydroimidazo[1,2-d][1,4]benzoxazepine · in 1 record
- EFV · {4-[2-(5,6-dimethoxypyridin-3-yl)-5-oxo-5,7-dihydro-6H-pyrrolo[3,4-b]pyridin-6-yl]-1H-pyrazol-1-yl}acetonitrile · in 1 record
- IGJ · 9-[(3~{R},4~{R})-4-fluoranylpyrrolidin-3-yl]-7-methyl-2-[(7-methylquinolin-6-yl)amino]purin-8-one · in 1 record
- V81 · 5-[2-amino-3-(1-methyl-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyrimidin-5-yl]-2-[(1S)-1-cyclopropylethyl]-7-(trifluoromethyl)-2,3-dihydro-1H-isoindol-1-one · in 1 record
- V84 · 2-amino-5-{2-[(1S)-1-cyclopropylethyl]-7-methyl-1-oxo-2,3-dihydro-1H-isoindol-5-yl}-N-(trans-3-hydroxycyclobutyl)pyrazolo[1,5-a]pyrimidine-3-carboxamide · in 1 record
- VL1 · Gedatolisib · in 1 record
- VLV · N~3~-{[5-(4-acetylphenyl)-4-methyl-1,3-thiazol-2-yl]carbamoyl}-N-tert-butyl-beta-alaninamide · in 1 record
- WJV · N-[2-(3,3-dimethylbutoxy)ethyl]-N'-{4-methyl-5-[(pyridin-4-yl)ethynyl]-1,3-thiazol-2-yl}urea · in 1 record
Elsewhere
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