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Ligand · L64

L64 · 1-(4-{4-morpholin-4-yl-1-[1-(pyridin-3-ylcarbonyl)piperidin-4-yl]-1H-pyrazolo[3,4-d]pyrimidin-6-yl}phenyl)-3-pyridin-4-ylurea

L64, 1-(4-{4-morpholin-4-yl-1-[1-(pyridin-3-ylcarbonyl)piperidin-4-yl]-1H-pyrazolo[3,4-d]pyrimidin-6-yl}phenyl)-3-pyridin-4-ylurea (C32 H32 N10 O3, 604.7 g/mol), in the MolNFT structures on GenesisL1: bound in 2 records (1 PDB entry).…

Component
L64
Formula
C32 H32 N10 O3
Class
ligand
Structures
2
PDB entries
1

Binding sites

L64 in 2 structures; the first of them:

  • 3IBE · Crystal Structure of a Pyrazolopyrimidine Inhibitor Bound to PI3 Kinase Gamma · L64 A1109 · binds MET804, ALA805, SER806, TRP812, ILE831, LYS833, ASP836, ASP837 and 18 more
  • 3IBE · Crystal structure of a pyrazolopyrimidine inhibitor bound to PI3 kinase gamma · L64 A1109 · binds MET804, ALA805, SER806, TRP812, ILE831, LYS833, ASP836, ASP837 and 18 more

Residues it binds most

ASP 2, ILE 2, ALA 2, GLN 2, MET 2, PHE 2, GLU 2, GLY 2, LEU 2, LYS 2 (residue and the binding sites it lines).

Found with

  • SO4 · Sulfate ion

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