V7Y · 2-amino-N-[(1S)-1-{8-[(1-methyl-1H-pyrazol-4-yl) ethynyl]-1-oxo-2-phenyl-1,2-dihydroisoquinolin-3-yl}ethyl]pyrazolo[1,5-a]pyrimidine-3-carboxamide

Binding sites

V7Y in 3 structures; the first of them:

• 7JWZ · IPI-549 bound to the PI3Kg catalytic subunit p110 gamma · V7Y A1201 · binds LYS802, VAL803, MET804, PRO810, LEU811, TRP812, ILE831, TYR867 and 8 more
• 6XRL · Crystal structure of human PI3K-gamma in complex with inhibitor ipi- 549 · V7Y A1101 · binds LYS802, VAL803, MET804, PRO810, LEU811, TRP812, ILE831, TYR867 and 9 more
• 7JWZ · Ipi-549 bound to the PI3KG catalytic subunit P110 gamma · V7Y A1201 · binds LYS802, VAL803, MET804, PRO810, LEU811, TRP812, ILE831, TYR867 and 8 more

Residues it binds most

ILE 3, LYS 3, MET 3, VAL 3, THR 3, GLU 3, LEU 3, PRO 3, TRP 3, TYR 3 (residue and the binding sites it lines).

Found with

• SO4 · Sulfate ion