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Ligand · 14K

14K · 4-(2-[(5-fluoro-6-methoxypyridin-3-yl)amino]-5-{(1R)-1-[4-(methylsulfonyl)piperazin-1-yl]ethyl}pyridin-3-yl)-6-methyl-1,3,5-triazin-2-amine

14K, 4-(2-[(5-fluoro-6-methoxypyridin-3-yl)amino]-5-{(1R)-1-[4-(methylsulfonyl)piperazin-1-yl]ethyl}pyridin-3-yl)-6-methyl-1,3,5-triazin-2-amine (C22 H28 F N9 O3 S, 517.6 g/mol), in the MolNFT structures on GenesisL1: bound in 2 records (1…

Component
14K
Formula
C22 H28 F N9 O3 S
Class
ligand
Structures
2
PDB entries
1

Binding sites

14K in 2 structures; the first of them:

  • 4FLH · Crystal structure of human PI3K-gamma in complex with AMG511 · 14K A1205 · binds LYS802, MET804, ALA805, PRO810, TRP812, ILE831, LYS833, LEU838 and 13 more
  • 4FLH · Crystal structure of human PI3K-gamma in complex with AMG511 · 14K A1205 · binds LYS802, MET804, ALA805, PRO810, TRP812, ILE831, LYS833, LEU838 and 13 more

Residues it binds most

ILE 2, ASP 2, ALA 2, LYS 2, MET 2, GLU 2, LEU 2, PHE 2, PRO 2, THR 2 (residue and the binding sites it lines).

Found with

  • SO4 · Sulfate ion

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