Ligand · WYF

WYF · (2Z)-4,6-dihydroxy-2-[(8-methoxy-1,2,3,4-tetrahydropyrazino[1,2-a]indol-10-yl)methylidene]-1-benzofuran-3(2H)-one

WYF, (2Z)-4,6-dihydroxy-2-[(8-methoxy-1,2,3,4-tetrahydropyrazino[1,2-a]indol-10-yl)methylidene]-1-benzofuran-3(2H)-one (C21 H18 N2 O5, 378.4 g/mol), in the MolNFT structures on GenesisL1: bound in 2 records (1 PDB entry). Every binding…

Component: WYF
Formula: C21 H18 N2 O5
Class: ligand
Structures: 2
PDB entries: 1

Binding sites

WYF in 2 structures; the first of them:

3MJW · PI3 Kinase gamma with a benzofura inhibitor · WYF A1 · binds MET804, TRP812, ILE831, LYS833, ASP836, ASP841, TYR867, ILE879 and 7 more
3MJW · PI3 kinase gamma with a benzofuranone inhibitor · WYF A1 · binds MET804, TRP812, ILE831, LYS833, ASP836, ASP841, TYR867, ILE879 and 7 more

Residues it binds most

ILE 2, ASP 2, MET 2, GLU 2, LYS 2, PHE 2, TRP 2, TYR 2, VAL 2 (residue and the binding sites it lines).

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