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Ligand · 093

093 · N-(5-(4-chloro-3-(2-hydroxy-ethylsulfamoyl)- phenylthiazole-2-yl)-acetamide

093, N-(5-(4-chloro-3-(2-hydroxy-ethylsulfamoyl)- phenylthiazole-2-yl)-acetamide (C14 H16 Cl N3 O4 S2, 389.9 g/mol), in the MolNFT structures on GenesisL1: bound in 8 records (4 PDB entries). Every binding site with its residues within 4.5…

Component
093
Formula
C14 H16 Cl N3 O4 S2
Class
ligand
Structures
8
PDB entries
4

Binding sites

093 in 8 structures; the first of them:

  • 2CHZ · A pharmacological map of the PI3-K family defines a role for p110alpha in signaling: The… · 093 A2093 · binds MET804, SER806, PRO810, TRP812, ILE831, LYS833, TYR867, ILE879 and 11 more
  • 2X6J · The crystal structure of the drosophila class III PI3-kinase VPS34 in complex with pik-93 · 093 A1949 · binds PHE673, LYS674, SER675, PRO679, ILE696, LYS698, ASP706, TYR732 and 11 more
  • 4D0L · Phosphatidylinositol 4-kinase III beta-PIK93 in a complex with Rab11a- GTP gammaS · 093 A2002 · binds LEU374, PRO381, ILE547, LYS549, GLU557, TYR583, ILE595, GLU596 and 8 more
  • 4D0M · Phosphatidylinositol 4-kinase III beta in a complex with Rab11a-GTP- gamma-S and the… · 093 A2002 · binds LEU374, PRO381, ILE547, LYS549, TYR583, ILE595, GLU596, PRO597 and 8 more
  • 2CHZ · A pharmacological MAP of the PI3-K family defines a role for P110ALPHA in signaling: the… · 093 A2093 · binds MET804, SER806, PRO810, TRP812, ILE831, LYS833, TYR867, ILE879 and 11 more
  • 2X6J · The crystal structure of the drosophila class III PI3-kinase VPS34 in complex with pik-93 · 093 A1949 · binds PHE673, LYS674, SER675, PRO679, ILE696, LYS698, ASP706, TYR732 and 11 more
  • 4D0L · Phosphatidylinositol 4-kinase III beta-PIK93 in a complex with RAB11A- GTP gammas · 093 A2002 · binds LEU374, PRO381, ILE547, LYS549, GLU557, TYR583, ILE595, GLU596 and 8 more
  • 4D0M · Phosphatidylinositol 4-kinase III beta in a complex with RAB11A-GTP- gamma-S and the… · 093 A2002 · binds LEU374, PRO381, ILE547, LYS549, TYR583, ILE595, GLU596, PRO597 and 8 more

Residues it binds most

ILE 36, LEU 34, PRO 36, GLU 34, ASP 36, VAL 36, TYR 36, LYS 36, ALA 32, ASN 24 (residue and the binding sites it lines).

Found with

  • GSP · 5'-guanosine-diphosphate-monothiophosphate
  • MG · Magnesium ion

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