UniProt P27707
Deoxycytidine kinase (P27707)
Deoxycytidine kinase (UniProt P27707), EC 2.7.1.113, 2.7.1.74: 95 experimental structures and 1 predicted model on GenesisL1, 10 ligands bound, 14 pockets. Binding sites, druggability and experiment against prediction (TM-score)…
- UniProt
- P27707
- Protein
- Deoxycytidine kinase
- EC
- 2.7.1.113, 2.7.1.74, 2.7.1.76
- Experimental structures
- 95
- Predicted models
- 1
- Ligands
- 10
- Pockets
- 14 · 3 records with a druggable one
Structures
96 records of P27707 in the MolNFT archive: 95 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1P5Z | Structure of human dCK complexed with cytarabine and ADP-MG | x-ray diffraction | B | — | — |
| 1P5Z | Structure of human dck complexed with cytarabine and ADP-mg | x-ray diffraction | B | — | — |
| 1P60 | Structure of human dCK complexed with 2'-Deoxycytidine and ADP, Space group C 2 2 21 | x-ray diffraction | A, B | — | — |
| 1P60 | Structure of human dck complexed with 2'-deoxycytidine and ADP, space group C 2 2 21 | x-ray diffraction | A, B | — | — |
| 1P61 | Structure of human dCK complexed with 2'-Deoxycytidine and ADP, P 43 21 2 space group | x-ray diffraction | B | — | — |
| 1P61 | Structure of human dck complexed with 2'-deoxycytidine and ADP, P 43 21 2 space group | x-ray diffraction | B | — | — |
| 1P62 | Structure of human dCK complexed with gemcitabine and ADP-MG | x-ray diffraction | B | — | — |
| 1P62 | Structure of human dck complexed with gemcitabine and ADP-mg | x-ray diffraction | B | — | — |
| 2A2Z | Crystal Structure of human deoxycytidine kinase in complex with deoxycytidine and uridine… | x-ray diffraction | A, B, C, D | — | — |
| 2A2Z | Crystal structure of human deoxycytidine kinase in complex with deoxycytidine and uridine… | x-ray diffraction | A, B, C, D | — | — |
| 2A30 | Crystal structure of human deoxycytidine kinase in complex with deoxycytidine | x-ray diffraction | A, B, C, D | — | — |
| 2A30 | Crystal structure of human deoxycytidine kinase in complex with deoxycytidine | x-ray diffraction | A, B, C, D | — | — |
| 2A7Q | Crystal structure of human dCK complexed with clofarabine and ADP | x-ray diffraction | A | — | — |
| 2A7Q | Crystal structure of human dck complexed with clofarabine and ADP | x-ray diffraction | A | — | — |
| 2NO0 | C4S dCK variant of dCK in complex with gemcitabine+ADP | x-ray diffraction | A, B | — | — |
| 2NO0 | C4S dck variant of dck in complex with GEMCITABINE+ADP | x-ray diffraction | A, B | — | — |
| 2NO1 | C4S dCK variant of dCK in complex with D-dC+ADP | x-ray diffraction | A, B | — | — |
| 2NO1 | C4S dck variant of dck in complex with D-DC+ADP | x-ray diffraction | A, B | — | — |
| 2NO6 | C4S dCK variant of dCK in complex with FTC+ADP | x-ray diffraction | A, B | — | — |
| 2NO6 | C4S dck variant of dck in complex with FTC+ADP | x-ray diffraction | A, B | — | — |
| 2NO7 | C4S dCK variant of dCK in complex with L-dC+ADP | x-ray diffraction | A, B | — | — |
| 2NO7 | C4S dck variant of dck in complex with L-DC+ADP | x-ray diffraction | A, B | — | — |
| 2NO9 | The structure of deoxycytidine kinase complexed with troxacitabine and ADP. | x-ray diffraction | A, B | — | — |
| 2NO9 | The structure of deoxycytidine kinase complexed with troxacitabine and ADP. | x-ray diffraction | A, B | — | — |
| 2NOA | The structure of deoxycytidine kinase complexed with lamivudine and ADP. | x-ray diffraction | A, B | — | — |
| 2NOA | The structure of deoxycytidine kinase complexed with lamivudine and ADP. | x-ray diffraction | A, B | — | — |
| 2QRN | Human Deoxycytidine kinase dCMP, UDP, Mg ion product complex | x-ray diffraction | A, B, C, D | — | — |
| 2QRN | Human deoxycytidine kinase dcmp, udp, mg ion product complex | x-ray diffraction | A, B, C, D | — | — |
| 2QRO | Human Deoxycytidine kinase dAMP, UDP, Mg ion product complex | x-ray diffraction | A, B, C, D | — | — |
| 2QRO | Human deoxycytidine kinase damp, udp, mg ion product complex | x-ray diffraction | A, B, C, D | — | — |
| 2ZI3 | C4S-E247A dCK variant of dCK in complex with D-dA+ADP | x-ray diffraction | A, B | — | — |
| 2ZI3 | C4S-E247A dck variant of dck in complex with D-DA+ADP | x-ray diffraction | A, B | — | — |
| 2ZI4 | C4S dCK variant of dCK in complex with L-dA+ADP | x-ray diffraction | A | — | — |
| 2ZI4 | C4S dck variant of dck in complex with L-DA+ADP | x-ray diffraction | A | — | — |
| 2ZI5 | C4S dCK variant of dCK in complex with L-dA+UDP | x-ray diffraction | A, B, C, D | — | — |
| 2ZI5 | C4S dck variant of dck in complex with L-DA+UDP | x-ray diffraction | A, B, C, D | — | — |
| 2ZI6 | C4S dCK variant of dCK in complex with D-dA+UDP | x-ray diffraction | A, B, C, D | — | — |
| 2ZI6 | C4S dck variant of dck in complex with D-DA+UDP | x-ray diffraction | A, B, C, D | — | — |
| 2ZI7 | C4S dCK variant of dCK in complex with D-dG+UDP | x-ray diffraction | B, A | — | — |
| 2ZI7 | C4S dck variant of dck in complex with D-DG+UDP | x-ray diffraction | B, A | — | — |
| 2ZI9 | C4S-E247A dCK variant of dCK in complex with cladribine+ADP | x-ray diffraction | A, B | — | — |
| 2ZI9 | C4S-E247A dck variant of dck in complex with CLADRIBINE+ADP | x-ray diffraction | A, B | — | — |
| 2ZIA | C4S dCK variant of dCK in complex with cladribine+UDP | x-ray diffraction | A, B | — | — |
| 2ZIA | C4S dck variant of dck in complex with CLADRIBINE+UDP | x-ray diffraction | A, B | — | — |
| 3HP1 | Crystal structure of human dCK R104M/D133A in complex with L-dT and ADP | x-ray diffraction | A | — | — |
| 3HP1 | Crystal structure of human dck R104M/D133A in complex with L-dt and ADP | x-ray diffraction | A | — | — |
| 3IPX | X-Ray structure of Human Deoxycytidine Kinase in complex with ADP and an inhibitor | x-ray diffraction | A | — | — |
| 3IPX | X-ray structure of human deoxycytidine kinase in complex with ADP and an inhibitor | x-ray diffraction | A | — | — |
| 3IPY | X-Ray structure of Human Deoxycytidine Kinase in complex with an inhibitor | x-ray diffraction | A, B | — | — |
| 3IPY | X-ray structure of human deoxycytidine kinase in complex with an inhibitor | x-ray diffraction | A, B | — | — |
| 3KFX | Human dCK complex with 5-Me dC and ADP | x-ray diffraction | A, B | — | — |
| 3KFX | Human dck complex with 5-me dc and ADP | x-ray diffraction | A, B | — | — |
| 3MJR | Human dCK complex with Acyclic Nucleoside | x-ray diffraction | A, B, C, D | — | — |
| 3MJR | Human dck complex with acyclic nucleoside | x-ray diffraction | A, B, C, D | — | — |
| 3QEJ | S74E-dCK mutant in complex with UDP | x-ray diffraction | A, B | — | — |
| 3QEJ | S74E-dck mutant in complex with udp | x-ray diffraction | A, B | — | — |
| 3QEN | S74E dCK in complex with 5-bromodeoxycytidine and UDP | x-ray diffraction | A, B | — | — |
| 3QEN | S74E dck in complex with 5-bromodeoxycytidine and udp | x-ray diffraction | A, B | — | — |
| 3QEO | S74E-R104M-D133A dCK variant in complex with L-deoxythymidine and UDP | x-ray diffraction | A, B | — | — |
| 3QEO | S74E-R104M-D133A dck variant in complex with L-deoxythymidine and udp | x-ray diffraction | A, B | — | — |
36 records more on the page itself.
Ligands
- UDP · Uridine-5'-diphosphate · in 7 records
- MG · Magnesium ion · in 4 records
- DCM · 2'-deoxycytidine-5'-monophosphate · in 3 records
- G65 · Masitinib · in 2 records
- NA · Sodium ion · in 2 records
- J7I · 2-[2-[[5-[3-methoxy-4-(4-methylpiperazin-1-yl)sulfonyl-phenyl]-2-methyl-phenyl]-propyl-amino]-1,3-thiazol-4-yl]pyrimidine-4,6-diamine · in 1 record
- J98 · 2-[2-[[2-methyl-5-[4-(4-methylpiperazin-1-yl)sulfonyl-2-(trifluoromethyl)phenyl]phenyl]-propyl-amino]-1,3-thiazol-4-yl]pyrimidine-4,6-diamine · in 1 record
- STI · 4-(4-methyl-piperazin-1-ylmethyl)-N-[4-methyl-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-phenyl]-benzamide · in 1 record
- UMP · 2'-deoxyuridine 5'-monophosphate · in 1 record
- VVC · 4-azanyl-1-[(2~{R},4~{S},5~{R})-5-ethynyl-5-(hydroxymethyl)-4-oxidanyl-oxolan-2-yl]pyrimidin-2-one · in 1 record
Experiment against prediction
- 2ZI4 chain A against the predicted model P27707: TM-score 0.99, RMSD 0.45 Å
- 2ZI4 chain A against the predicted model P27707: TM-score 0.99, RMSD 0.45 Å
- 2A7Q chain A against the predicted model P27707: TM-score 0.99, RMSD 0.51 Å
- 2A7Q chain A against the predicted model P27707: TM-score 0.99, RMSD 0.51 Å
- 2NO7 chain B against the predicted model P27707: TM-score 0.99, RMSD 0.50 Å
- 2NO7 chain B against the predicted model P27707: TM-score 0.99, RMSD 0.50 Å
- 2NO1 chain B against the predicted model P27707: TM-score 0.99, RMSD 0.53 Å
- 2NO1 chain B against the predicted model P27707: TM-score 0.99, RMSD 0.53 Å
- 2NO0 chain B against the predicted model P27707: TM-score 0.99, RMSD 0.53 Å
- 2NO0 chain B against the predicted model P27707: TM-score 0.99, RMSD 0.53 Å
Elsewhere
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