UniProt P0A8T7
DNA-directed RNA polymerase subunit beta' (P0A8T7)
DNA-directed RNA polymerase subunit beta' (UniProt P0A8T7), EC 2.7.7.6: 278 experimental structures and 1 predicted model on GenesisL1, 23 ligands bound, 1,880 pockets. Binding sites, druggability and experiment against…
- UniProt
- P0A8T7
- Protein
- DNA-directed RNA polymerase subunit beta'
- EC
- 2.7.7.6
- Experimental structures
- 278
- Predicted models
- 1
- Ligands
- 23
- Pockets
- 1,880 · 153 records with a druggable one
Structures
279 records of P0A8T7 in the MolNFT archive: 278 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 2AUK | Structure of E. coli RNA polymerase beta' G/G' insert | x-ray diffraction | A, B, C, D, E | — | — |
| 2AUK | Structure of E. COLI RNA polymerase beta' G/G' insert | x-ray diffraction | A, B, C, D, E | — | — |
| 2LMC | Structure of T7 transcription factor Gp2-E. coli RNAp jaw domain complex | solution nmr | B | — | — |
| 2LMC | Structure of T7 transcription factor GP2-E. COLI rnap jaw domain complex | solution nmr | B | — | — |
| 3IYD | Three-dimensional EM structure of an intact activator-dependent transcription initiation complex | electron microscopy | D | — | — |
| 3IYD | Three-dimensional EM structure of an intact activator-dependent transcription initiation complex | electron microscopy | D | — | — |
| 3LU0 | Molecular model of Escherichia coli core RNA polymerase | electron microscopy | D | — | — |
| 3LU0 | Molecular model of escherichia COLI core RNA polymerase | electron microscopy | D | — | — |
| 4IQZ | The crystal structure of a large insert in RNA polymerase (RpoC) subunit from E. coli | x-ray diffraction | A, B, C, D, E | — | — |
| 4IQZ | The crystal structure of a large insert in RNA polymerase (rpoc) subunit from E. COLI | x-ray diffraction | A, B, C, D, E | — | — |
| 4JK1 | X-ray crystal structure of Escherichia coli sigma70 holoenzyme in complex with Guanosine… | x-ray diffraction | D, I | — | — |
| 4JK1 | X-ray crystal structure of escherichia COLI SIGMA70 holoenzyme in complex with guanosine… | x-ray diffraction | D, I | — | — |
| 4JK2 | X-ray crystal structure of Escherichia coli sigma70 holoenzyme in complex with guanosine… | x-ray diffraction | D, I | — | — |
| 4JK2 | X-ray crystal structure of escherichia COLI SIGMA70 holoenzyme in complex with guanosine… | x-ray diffraction | D, I | — | — |
| 4KMU | X-ray crystal structure of the Escherichia coli RNA polymerase in complex with Rifampin | x-ray diffraction | D, I | — | — |
| 4KMU | X-ray crystal structure of the escherichia COLI RNA polymerase in complex with rifampin | x-ray diffraction | D, I | — | — |
| 4KN4 | X-ray crystal structure of the Escherichia coli RNA polymerase in complex with… | x-ray diffraction | D, I | — | — |
| 4KN4 | X-ray crystal structure of the escherichia COLI RNA polymerase in complex with… | x-ray diffraction | D, I | — | — |
| 4KN7 | X-ray crystal structure of the Escherichia coli RNA polymerase in complex with… | x-ray diffraction | D, I | — | — |
| 4KN7 | X-ray crystal structure of the escherichia COLI RNA polymerase in complex with… | x-ray diffraction | D, I | — | — |
| 4MEX | Crystal structure of Escherichia coli RNA polymerase in complex with salinamide A | x-ray diffraction | D, J | — | — |
| 4MEX | Crystal structure of escherichia COLI RNA polymerase in complex with salinamide a | x-ray diffraction | D, J | — | — |
| 4MEY | Crystal structure of Escherichia coli RNA polymerase holoenzyme | x-ray diffraction | D, J | — | — |
| 4MEY | Crystal structure of escherichia COLI RNA polymerase holoenzyme | x-ray diffraction | D, J | — | — |
| 4ZH2 | Crystal structure of Escherichia coli RNA polymerase in complex with CBR703 | x-ray diffraction | D, J | 4OB, MG, ZN | 13 (best 0.83) |
| 4ZH2 | Crystal structure of escherichia COLI RNA polymerase in complex with CBR703 | x-ray diffraction | D, J | — | — |
| 4ZH3 | Crystal structure of Escherichia coli RNA polymerase in complex with CBRH16-Br | x-ray diffraction | D, J | MG, ZN, 4OD | 13 (best 0.84) |
| 4ZH3 | Crystal structure of escherichia COLI RNA polymerase in complex with CBRH16-br | x-ray diffraction | D, J | — | — |
| 4ZH4 | Crystal structure of Escherichia coli RNA polymerase in complex with CBRP18 | x-ray diffraction | D, J | 4OE, MG, ZN | 13 (best 0.84) |
| 4ZH4 | Crystal structure of escherichia COLI RNA polymerase in complex with CBRP18 | x-ray diffraction | D, J | — | — |
| 5BYH | Crystal structure of escherichia COLI RNA polymerase - SIGMA54 holoenzyme complex | x-ray diffraction | D | — | — |
| 5IPL | SigmaS-transcription initiation complex with 4-nt nascent RNA | x-ray diffraction | D | DPO, ZN, MG | — |
| 5IPL | Sigmas-transcription initiation complex with 4-nt nascent RNA | x-ray diffraction | D | — | — |
| 5IPM | SigmaS-transcription initiation complex with 4-nt nascent RNA | x-ray diffraction | D | ZN, MG | — |
| 5IPM | Sigmas-transcription initiation complex with 4-nt nascent RNA | x-ray diffraction | D | — | — |
| 5IPN | SigmaS-transcription initiation complex with 4-nt nascent RNA | x-ray diffraction | D | ZN, MG | 15 (best 0.82) |
| 5IPN | Sigmas-transcription initiation complex with 4-nt nascent RNA | x-ray diffraction | D | — | — |
| 5MS0 | pseudo-atomic model of the RNA polymerase lambda-based antitermination complex solved by cryo-EM | electron microscopy | D | MG, ZN | — |
| 5MS0 | Pseudo-atomic model of the RNA polymerase lambda-based antitermination complex solved by cryo-EM | electron microscopy | D | MG, ZN | — |
| 5MY1 | E. coli expressome | electron microscopy | Y | ZN | — |
| 5MY1 | E. COLI expressome | electron microscopy | Y | ZN | — |
| 5NSR | Cryo-EM structure of RNA polymerase-sigma54 holo enzyme with promoter DNA closed complex | electron microscopy | D | — | 11 (best 0.84) |
| 5NSR | Cryo-EM structure of RNA polymerase-SIGMA54 holo enzyme with promoter DNA closed complex | electron microscopy | D | — | — |
| 5NSS | Cryo-EM structure of RNA polymerase-sigma54 holoenzyme with promoter DNA and transcription… | electron microscopy | D | — | 8 (best 0.86) |
| 5NSS | Cryo-EM structure of RNA polymerase-SIGMA54 holoenzyme with promoter DNA and transcription… | electron microscopy | D | — | — |
| 5NWT | Crystal Structure of Escherichia coli RNA polymerase - Sigma54 Holoenzyme complex | x-ray diffraction | D | ZN, MG | 12 (best 0.88) |
| 5NWT | Crystal structure of escherichia COLI RNA polymerase - SIGMA54 holoenzyme complex | x-ray diffraction | D | ZN, MG | — |
| 5UAC | Escherichia coli RNA polymerase and Rifampin complex, wild-type | x-ray diffraction | D, J | MG, ZN | — |
| 5UAC | Escherichia COLI RNA polymerase and rifampin complex, wild-type | x-ray diffraction | D, J | MG, ZN | — |
| 5UAG | Escherichia coli RNA polymerase mutant - RpoB D516V | x-ray diffraction | D, J | MG, ZN | — |
| 5UAG | Escherichia COLI RNA polymerase mutant - rpob D516V | x-ray diffraction | D, J | MG, ZN | — |
| 5UAH | Escherichia coli RNA polymerase and Rifampin complex, RpoB D516V mutant | x-ray diffraction | D, J | MG, ZN | — |
| 5UAH | Escherichia COLI RNA polymerase and rifampin complex, rpob D516V mutant | x-ray diffraction | D, J | MG, ZN | — |
| 5UAJ | Escherichia coli RNA polymerase RpoB S531L mutant | x-ray diffraction | D, J | MG, ZN | 13 (best 0.85) |
| 5UAJ | Escherichia COLI RNA polymerase rpob S531L mutant | x-ray diffraction | D, J | MG, ZN | — |
| 5UAL | Escherichia coli RNA polymerase and Rifampin complex, RpoB S531L mutant | x-ray diffraction | D, J | MG, ZN | 12 (best 0.85) |
| 5UAL | Escherichia COLI RNA polymerase and rifampin complex, rpob S531L mutant | x-ray diffraction | D, J | MG, ZN | — |
| 5UAQ | Escherichia coli RNA polymerase RpoB H526Y mutant | x-ray diffraction | D, J | MG, ZN | 9 (best 0.84) |
| 5UAQ | Escherichia COLI RNA polymerase rpob H526Y mutant | x-ray diffraction | D, J | MG, ZN | — |
| 5VSW | X-ray crystal structure of Escherichia coli RNA polymerase and DksA/ppGpp complex | x-ray diffraction | D, J | MG, ZN, G4P | 12 (best 0.85) |
219 records more on the page itself.
Ligands
- ZN · Zinc ion · in 222 records
- MG · Magnesium ion · in 220 records
- 1N7 · Chapso · in 23 records
- DPO · Diphosphate · in 7 records
- G4P · Guanosine-5',3'-tetraphosphate · in 7 records
- CTP · Cytidine-5'-triphosphate · in 6 records
- 4QM · (3R,5S,7R,8R,9S,10S,12S,13R,14S,17R)-10,13-dimethyl-17-[(2R)-pentan-2-yl]-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthrene-3,7,12-triol · in 3 records
- GTP · Guanosine-5'-triphosphate · in 3 records
- UTP · Uridine 5'-triphosphate · in 3 records
- ECJ · (5R)-5-(6-amino-9H-purin-9-yl)-2-({[(S)-hydroxy(phosphonooxy)phosphoryl]oxy}methyl)-4-oxo-4,5-dihydrofuran-3-yl trihydrogen diphosphate · in 2 records
- POP · Pyrophosphate 2- · in 2 records
- QZY · 3-{[benzyl(ethyl)carbamoyl]amino}-5-(4-phenoxyphenyl) thiophene-2-carboxylic acid · in 2 records
- 2DA · 2',3'-dideoxyadenosine-5'-monophosphate · in 1 record
- 4OB · N-hydroxy-N'-phenyl-3-(trifluoromethyl)benzenecarboximidamide · in 1 record
- 4OD · N'-(3-bromophenyl)-4-fluoro-N-hydroxy-3-(trifluoromethyl)benzenecarboximidamide · in 1 record
- 4OE · 5-(4-fluorophenyl)-4-[4-fluoro-3-(trifluoromethyl)phenyl]-1H-pyrazole · in 1 record
- ATP · Adenosine-5'-triphosphate · in 1 record
- D4M · [(5R)-5-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-2,5-dihydrofuran-2-yl]methyl dihydrogen phosphate · in 1 record
- DG3 · 2'-3'-dideoxyguanosine-5'-triphosphate · in 1 record
- DGP · 2'-deoxyguanosine-5'-monophosphate · in 1 record
- S9F · [[(2~{R},3~{S},4~{R},5~{R})-5-(4-azanyl-2-oxidanylidene-1$l^{4},3,5,7-tetrazabicyclo[4.3.0]nona-1(6),3,8-trien-7-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-oxidanyl-phosphoryl] phosphono hydrogen phosphate · in 1 record
- X0F · 2-oxo-2-hydroadenosine 5'-(tetrahydrogen triphosphate) · in 1 record
- X0O · [[(2~{R},3~{S},4~{R},5~{S})-5-(4-azanyl-1-methyl-2-oxidanylidene-pyrimidin-5-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-oxidanyl-phosphoryl] phosphono hydrogen phosphate · in 1 record
Experiment against prediction
- 6BYU chain J against the predicted model P0A8T7: TM-score 0.98, RMSD 1.43 Å
- 6CUX chain J against the predicted model P0A8T7: TM-score 0.98, RMSD 1.48 Å
- 5UAG chain J against the predicted model P0A8T7: TM-score 0.98, RMSD 1.49 Å
- 5UAG chain J against the predicted model P0A8T7: TM-score 0.98, RMSD 1.49 Å
- 8IGS chain J against the predicted model P0A8T7: TM-score 0.98, RMSD 1.60 Å
- 5UAJ chain J against the predicted model P0A8T7: TM-score 0.98, RMSD 1.53 Å
- 5UAJ chain J against the predicted model P0A8T7: TM-score 0.98, RMSD 1.53 Å
- 5UAQ chain J against the predicted model P0A8T7: TM-score 0.98, RMSD 1.54 Å
- 5UAQ chain J against the predicted model P0A8T7: TM-score 0.98, RMSD 1.54 Å
- 8IGR chain J against the predicted model P0A8T7: TM-score 0.98, RMSD 1.62 Å
Elsewhere
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