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Ligand · D4M

D4M · [(5R)-5-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-2,5-dihydrofuran-2-yl]methyl dihydrogen phosphate

D4M, [(5R)-5-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-2,5-dihydrofuran-2-yl]methyl dihydrogen phosphate (C10 H13 N2 O7 P, 304.2 g/mol), in the MolNFT structures on GenesisL1: bound in 4 records (3 PDB entries). Every binding site…

Component
D4M
Formula
C10 H13 N2 O7 P
Class
ligand
Structures
4
PDB entries
3

Binding sites

D4M in 4 structures; the first of them:

  • 1Z4Q · Structure of the D41N variant of the human mitochondrial deoxyribonucleotidase in complex… · D4M A1489 · binds ASN41, ASP43, PHE49, PHE75, TRP76, VAL77, SER78, TRP96 and 7 more
  • 6UU3 · E. coli sigma-S transcription initiation complex with a 4-nt RNA and a CTP ("Old" crystal… · D4M 333101 · binds GLU565, LYS1065, LYS1073, ARG425, ASP462, ASP464, DA13, G16
  • 6WPF · Structure of HIV-1 Reverse Transcriptase (RT) in complex with dsDNA and d4T · D4M P901 · binds DG822, LYS66, ASP110, ASP186, LYS220, GLN222, LEU228
  • 1Z4Q · Structure of the D41N variant of the human mitochondrial deoxyribonucleotidase in complex… · D4M A1489 · binds ASN41, ASP43, PHE49, PHE75, TRP76, VAL77, SER78, TRP96 and 7 more

Residues it binds most

ASP 4, LYS 4, PHE 2, SER 2, TRP 2, ASN 2, ILE 2, THR 2, VAL 2, ARG 1 (residue and the binding sites it lines).

Found with

  • MG · Magnesium ion
  • CTP · Cytidine-5'-triphosphate
  • D4T · 2',3'-dehydro-2',3'-deoxy-thymidine 5'-triphosphate
  • ZN · Zinc ion
  • SO4 · Sulfate ion
  • GOL · Glycerol

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