UniProt P00533
epidermal growth factor receptor (P00533)
epidermal growth factor receptor (UniProt P00533), EC 2.7.1.112, 2.7.10.1: 578 experimental structures and 1 predicted model on GenesisL1, 183 ligands bound, 3,484 pockets. Binding sites, druggability and experiment against…
- UniProt
- P00533
- Protein
- epidermal growth factor receptor
- EC
- 2.7.1.112, 2.7.10.1
- Experimental structures
- 578
- Predicted models
- 1
- Ligands
- 183
- Pockets
- 3,484 · 543 records with a druggable one
Structures
579 records of P00533 in the MolNFT archive: 578 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1IVO | Crystal Structure of the Complex of Human Epidermal Growth Factor and Receptor Extracellular… | x-ray diffraction | A, B | NAG | 14 (best 0.78) |
| 1IVO | Crystal structure of the complex of human epidermal growth factor and receptor extracellular… | x-ray diffraction | A, B | NAG | 14 (best 0.78) |
| 1M14 | Tyrosine Kinase Domain from Epidermal Growth Factor Receptor | x-ray diffraction | A | — | 3 (best 0.63) |
| 1M14 | Tyrosine kinase domain from epidermal growth factor receptor | x-ray diffraction | A | — | 3 (best 0.63) |
| 1M17 | Epidermal Growth Factor Receptor tyrosine kinase domain with 4-anilinoquinazoline inhibitor… | x-ray diffraction | A | AQ4 | 1 (best 0.64) |
| 1M17 | Epidermal growth factor receptor tyrosine kinase domain with 4-anilinoquinazoline inhibitor… | x-ray diffraction | A | AQ4 | 1 (best 0.64) |
| 1MOX | Crystal Structure of Human Epidermal Growth Factor Receptor (residues 1-501) in complex with… | x-ray diffraction | A, B | NAG, FUC, BMA, MAN, PT, CD | 11 (best 0.80) |
| 1MOX | Crystal structure of human epidermal growth factor receptor (residues 1-501) in complex with… | x-ray diffraction | A, B | NAG, FUC, BMA, MAN, PT, CD | 11 (best 0.80) |
| 1XKK | EGFR kinase domain complexed with a quinazoline inhibitor- GW572016 | x-ray diffraction | A | PO4, FMM | 4 (best 0.72) |
| 1XKK | EGFR kinase domain complexed with a quinazoline inhibitor- GW572016 | x-ray diffraction | A | PO4, FMM | 4 (best 0.72) |
| 1YY9 | Structure of the extracellular domain of the epidermal growth factor receptor in complex with the… | x-ray diffraction | A | NAG, BMA, MAN | 9 (best 0.51) |
| 1YY9 | Structure of the extracellular domain of the epidermal growth factor receptor in complex with the… | x-ray diffraction | A | NAG, BMA, MAN | 9 (best 0.51) |
| 1Z9I | A Structural Model for the Membrane-Bound Form of the Juxtamembrane Domain of the Epidermal Growth… | solution nmr | A | — | — |
| 1Z9I | A structural model for the membrane-bound form of the juxtamembrane domain of the epidermal growth… | solution nmr | A | — | — |
| 2EB2 | Crystal structure of mutated EGFR kinase domain (G719S) | x-ray diffraction | A | — | 4 (best 0.55) |
| 2EB2 | Crystal structure of mutated EGFR kinase domain (G719S) | x-ray diffraction | A | — | 4 (best 0.55) |
| 2EB3 | Crystal structure of mutated EGFR kinase domain (L858R) in complex with AMPPNP | x-ray diffraction | A | ANP | 2 (best 0.61) |
| 2EB3 | Crystal structure of mutated EGFR kinase domain (L858R) in complex with amppnp | x-ray diffraction | A | ANP | 2 (best 0.61) |
| 2GS2 | Crystal Structure of the active EGFR kinase domain | x-ray diffraction | A | — | 4 (best 0.60) |
| 2GS2 | Crystal structure of the active EGFR kinase domain | x-ray diffraction | A | — | 4 (best 0.60) |
| 2GS7 | Crystal Structure of the inactive EGFR kinase domain in complex with AMP-PNP | x-ray diffraction | A, B | MG, IOD, ANP | 5 (best 0.75) |
| 2GS7 | Crystal structure of the inactive EGFR kinase domain in complex with AMP-pnp | x-ray diffraction | A, B | MG, IOD, ANP | 5 (best 0.75) |
| 2ITN | Crystal structure of EGFR kinase domain G719S mutation in complex with AMP-PNP | x-ray diffraction | A | MG, ANP | 3 (best 0.65) |
| 2ITN | Crystal structure of EGFR kinase domain G719S mutation in complex with AMP-pnp | x-ray diffraction | A | MG, ANP | 3 (best 0.65) |
| 2ITO | Crystal structure of EGFR kinase domain G719S mutation in complex with Iressa | x-ray diffraction | A | IRE | 4 (best 0.66) |
| 2ITO | Crystal structure of EGFR kinase domain G719S mutation in complex with iressa | x-ray diffraction | A | IRE | 4 (best 0.66) |
| 2ITP | Crystal structure of EGFR kinase domain G719S mutation in complex with AEE788 | x-ray diffraction | A | AEE | 3 (best 0.65) |
| 2ITP | Crystal structure of EGFR kinase domain G719S mutation in complex with AEE788 | x-ray diffraction | A | AEE | 3 (best 0.65) |
| 2ITQ | Crystal structure of EGFR kinase domain G719S mutation in complex with AFN941 | x-ray diffraction | A | ITQ | 2 (best 0.63) |
| 2ITQ | Crystal structure of EGFR kinase domain G719S mutation in complex with AFN941 | x-ray diffraction | A | ITQ | 2 (best 0.63) |
| 2ITT | Crystal structure of EGFR kinase domain L858R mutation in complex with AEE788 | x-ray diffraction | A | AEE | 3 (best 0.65) |
| 2ITT | Crystal structure of EGFR kinase domain L858R mutation in complex with AEE788 | x-ray diffraction | A | AEE | 3 (best 0.65) |
| 2ITU | Crystal structure of EGFR kinase domain L858R mutation in complex with AFN941 | x-ray diffraction | A | ITQ | 3 (best 0.62) |
| 2ITU | Crystal structure of EGFR kinase domain L858R mutation in complex with AFN941 | x-ray diffraction | A | ITQ | 3 (best 0.62) |
| 2ITV | Crystal structure of EGFR kinase domain L858R mutation in complex with AMP-PNP | x-ray diffraction | A | ANP | 2 (best 0.68) |
| 2ITV | Crystal structure of EGFR kinase domain L858R mutation in complex with AMP-pnp | x-ray diffraction | A | ANP | 2 (best 0.68) |
| 2ITW | Crystal structure of EGFR kinase domain in complex with AFN941 | x-ray diffraction | A | ITQ | 3 (best 0.62) |
| 2ITW | Crystal structure of EGFR kinase domain in complex with AFN941 | x-ray diffraction | A | ITQ | 3 (best 0.62) |
| 2ITX | Crystal structure of EGFR kinase domain in complex with AMP-PNP | x-ray diffraction | A | ANP | 3 (best 0.66) |
| 2ITX | Crystal structure of EGFR kinase domain in complex with AMP- pnp | x-ray diffraction | A | ANP | 3 (best 0.66) |
| 2ITY | Crystal structure of EGFR kinase domain in complex with Iressa | x-ray diffraction | A | IRE | 4 (best 0.60) |
| 2ITY | Crystal structure of EGFR kinase domain in complex with iressa | x-ray diffraction | A | IRE | 4 (best 0.60) |
| 2ITZ | Crystal structure of EGFR kinase domain L858R mutation in complex with Iressa | x-ray diffraction | A | CL, IRE | 4 (best 0.60) |
| 2ITZ | Crystal structure of EGFR kinase domain L858R mutation in complex with iressa | x-ray diffraction | A | CL, IRE | 4 (best 0.60) |
| 2J5E | Crystal structure of EGFR kinase domain in complex with an irreversible inhibitor 13-jab | x-ray diffraction | A | CL | 2 (best 0.56) |
| 2J5E | Crystal structure of EGFR kinase domain in complex with an irreversible inhibitor 13-jab | x-ray diffraction | A | CL | 2 (best 0.56) |
| 2J5F | Crystal structure of EGFR kinase domain in complex with an irreversible inhibitor 34-jab | x-ray diffraction | A | DJK | 3 (best 0.68) |
| 2J5F | Crystal structure of EGFR kinase domain in complex with an irreversible inhibitor 34-jab | x-ray diffraction | A | DJK | 3 (best 0.68) |
| 2J6M | Crystal structure of EGFR kinase domain in complex with AEE788 | x-ray diffraction | A | AEE | 4 (best 0.67) |
| 2J6M | Crystal structure of EGFR kinase domain in complex with AEE788 | x-ray diffraction | A | AEE | 4 (best 0.67) |
| 2JIT | Crystal structure of EGFR kinase domain T790M mutation | x-ray diffraction | A, B | — | 6 (best 0.71) |
| 2JIT | Crystal structure of EGFR kinase domain T790M mutation | x-ray diffraction | A, B | — | 6 (best 0.71) |
| 2JIU | Crystal structure of EGFR kinase domain T790M mutation in complex with AEE788 | x-ray diffraction | A, B | AEE | 4 (best 0.72) |
| 2JIU | Crystal structure of EGFR kinase domain T790M mutation in complex with AEE788 | x-ray diffraction | A, B | AEE | 4 (best 0.72) |
| 2JIV | Crystal structure of EGFR kinase domain T790M mutation in compex with HKI-272 | x-ray diffraction | A, B | HKI, CL | 9 (best 0.83) |
| 2JIV | Crystal structure of EGFR kinase domain T790M mutation in compex with hki-272 | x-ray diffraction | A, B | HKI, CL | 9 (best 0.83) |
| 2KS1 | Heterodimeric association of Transmembrane domains of ErbB1 and ErbB2 receptors Enabling Kinase… | solution nmr | B | — | — |
| 2KS1 | Heterodimeric association of transmembrane domains of ERBB1 and ERBB2 receptors enabling kinase… | solution nmr | B | — | — |
| 2M0B | Homodimeric transmembrane domain of the human receptor tyrosine kinase ErbB1 (EGFR, HER1) in… | solution nmr | A, B | — | 1 (best 0.36) |
| 2M0B | Homodimeric transmembrane domain of the human receptor tyrosine kinase ERBB1 (EGFR, HER1) in… | solution nmr | A, B | — | 1 (best 0.36) |
519 records more on the page itself.
Ligands
- SO4 · Sulfate ion · in 98 records
- CL · Chloride ion · in 63 records
- ANP · Phosphoaminophosphonic acid-adenylate ester · in 58 records
- MG · Magnesium ion · in 57 records
- NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · in 54 records
- BMA · beta-D-mannopyranose · in 31 records
- MAN · alpha-D-mannopyranose · in 29 records
- YY3 · N-(2-{[2-(dimethylamino)ethyl](methyl)amino}-4-methoxy-5-{[4-(1-methyl-1H-indol-3-yl)pyrimidin-2-yl]amino}phenyl)prop-2-enamide · in 20 records
- IRE · Gefitinib · in 12 records
- NA · Sodium ion · in 10 records
- VNS · (2R)-2-(5-fluoro-2-hydroxyphenyl)-2-{6-[4-(1-methylpiperidin-4-yl)phenyl]-1-oxo-1,3-dihydro-2H-isoindol-2-yl}-N-(1,3-thiazol-2-yl)acetamide · in 10 records
- 8BS · N-[(3R,4R)-4-fluoro-1-{6-[(3-methoxy-1-methyl-1H-pyrazol-4-yl)amino]-9-methyl-9H-purin-2-yl}pyrrolidin-3-yl]propanamide · in 8 records
- 9LL · (2R)-2-(5-fluoro-2-hydroxyphenyl)-2-(1-oxo-1,3-dihydro-2H-isoindol-2-yl)-N-(1,3-thiazol-2-yl)acetamide · in 8 records
- AEE · 6-{4-[(4-ethylpiperazin-1-yl)methyl]phenyl}-N-[(1R)-1-phenylethyl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine · in 8 records
- Q6K · ~{N}-[2-[2-(dimethylamino)ethyl-methyl-amino]-4-methoxy-5-[[4-(1-methylindol-3-yl)pyrimidin-2-yl]amino]phenyl]propanamide · in 7 records
- R28 · propan-2-yl 2-[[4-[2-(dimethylamino)ethyl-methyl-amino]-2-methoxy-5-(propanoylamino)phenyl]amino]-4-(1-methylindol-3-yl)pyrimidine-5-carboxylate · in 7 records
- 57N · (2R)-2-(1-oxo-1,3-dihydro-2H-isoindol-2-yl)-2-phenyl-N-(1,3-thiazol-2-yl)acetamide · in 6 records
- ADP · Adenosine-5'-diphosphate · in 6 records
- IOD · Iodide ion · in 6 records
- ITQ · 1,2,3,4-Tetrahydrogen Staurosporine · in 6 records
- JBJ · (2R)-2-(5-fluoro-2-hydroxyphenyl)-2-{1-oxo-6-[4-(piperazin-1-yl)phenyl]-1,3-dihydro-2H-isoindol-2-yl}-N-(1,3-thiazol-2-yl)acetamide · in 6 records
- PO4 · Phosphate ion · in 6 records
- 0UN · N-{3-[(5-chloro-2-{[2-methoxy-4-(4-methylpiperazin-1-yl)phenyl]amino}pyrimidin-4-yl)oxy]phenyl}prop-2-enamide · in 5 records
- FUC · alpha-L-fucopyranose · in 5 records
- 03P · N-{2-[4-({3-chloro-4-[3-(trifluoromethyl)phenoxy]phenyl}amino)-5H-pyrrolo[3,2-d]pyrimidin-5-yl]ethyl}-3-hydroxy-3-methylbutanamide · in 4 records
- 0WN · N-{4-[(3-chloro-4-fluorophenyl)amino]-7-[(3S)-tetrahydrofuran-3-yloxy]quinazolin-6-yl}-4-(dimethylamino)butanamide · in 4 records
- 1C9 · (2E)-N-{4-[(3-chloro-4-fluorophenyl)amino]-7-methoxyquinazolin-6-yl}-4-(piperidin-1-yl)but-2-enamide · in 4 records
- 4ZQ · (1R)-1-{6-({2-[(3R,4S)-3-fluoro-4-methoxypiperidin-1-yl]pyrimidin-4-yl}amino)-1-[(2S)-1,1,1-trifluoropropan-2-yl]-1H-imidazo[4,5-c]pyridin-2-yl}ethanol · in 4 records
- 5Q4 · 4-[(2-methoxyphenyl)amino]-~{N}-[4-(4-methylpiperazin-1-yl)phenyl]-2-oxidanylidene-1~{H}-pyridine-3-carboxamide · in 4 records
- 5X4 · ~{N}-[7-methyl-1-[(3~{R})-1-propanoylazepan-3-yl]benzimidazol-2-yl]-3-(trifluoromethyl)benzamide · in 4 records
Experiment against prediction
- 4KRM chain K against the predicted model P00533: TM-score 0.99, RMSD 0.41 Å
- 4KRM chain K against the predicted model P00533: TM-score 0.99, RMSD 0.41 Å
- 6B3S chain A against the predicted model P00533: TM-score 0.99, RMSD 0.41 Å
- 6B3S chain A against the predicted model P00533: TM-score 0.99, RMSD 0.41 Å
- 6B3S chain I against the predicted model P00533: TM-score 0.99, RMSD 0.42 Å
- 6B3S chain I against the predicted model P00533: TM-score 0.99, RMSD 0.42 Å
- 4KRM chain E against the predicted model P00533: TM-score 0.99, RMSD 0.44 Å
- 4KRM chain E against the predicted model P00533: TM-score 0.99, RMSD 0.44 Å
- 6B3S chain E against the predicted model P00533: TM-score 0.99, RMSD 0.44 Å
- 6B3S chain E against the predicted model P00533: TM-score 0.99, RMSD 0.44 Å
Elsewhere
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