Ligand · 4ZQ

4ZQ · (1R)-1-{6-({2-[(3R,4S)-3-fluoro-4-methoxypiperidin-1-yl]pyrimidin-4-yl}amino)-1-[(2S)-1,1,1-trifluoropropan-2-yl]-1H-imidazo[4,5-c]pyridin-2-yl}ethanol

4ZQ, (1R)-1-{6-({2-[(3R,4S)-3-fluoro-4-methoxypiperidin-1-yl]pyrimidin-4-yl}amino)-1-[(2S)-1,1,1-trifluoropropan-2-yl]-1H-imidazo[4,5-c]pyridin-2-yl}ethanol (C21 H25 F4 N7 O2, 483.5 g/mol), in the MolNFT structures on GenesisL1: bound in 2…

Component: 4ZQ
Formula: C21 H25 F4 N7 O2
Class: ligand
Structures: 2
PDB entries: 2

Binding sites

4ZQ in 2 structures; the first of them:

5CAS · EGFR kinase domain mutant "tmlr" with compound 41A · 4ZQ A1102 · binds LEU718, GLY719, PHE723, VAL726, ALA743, LYS745, GLU762, MET766 and 11 more
5CAV · EGFR kinase domain with compound 41A · 4ZQ A1101 · binds LEU718, GLY719, PHE723, VAL726, ALA743, LYS745, GLU762, CYS775 and 9 more

Residues it binds most

LEU 2, CYS 2, GLY 2, MET 2, ASP 2, THR 2, ALA 2, GLN 2, GLU 2, LYS 2 (residue and the binding sites it lines).

Found with

SO4 · Sulfate ion

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