AEE · 6-{4-[(4-ethylpiperazin-1-yl)methyl]phenyl}-N-[(1R)-1-phenylethyl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine

Binding sites

AEE in 8 structures; the first of them:

• 2ITP · Crystal structure of EGFR kinase domain G719S mutation in complex with AEE788 · AEE A2019 · binds LEU718, VAL726, ALA743, ILE744, LYS745, MET766, LEU788, THR790 and 11 more
• 2ITT · Crystal structure of EGFR kinase domain L858R mutation in complex with AEE788 · AEE A2020 · binds LEU718, VAL726, ALA743, ILE744, LYS745, MET766, LEU788, THR790 and 10 more
• 2J6M · Crystal structure of EGFR kinase domain in complex with AEE788 · AEE A2021 · binds LEU718, VAL726, ALA743, ILE744, LYS745, GLU762, MET766, LEU788 and 12 more
• 2JIU · Crystal structure of EGFR kinase domain T790M mutation in complex with AEE788 · AEE A2017 · binds LEU718, VAL726, ALA743, ILE744, LYS745, LEU788, MET790, GLN791 and 10 more
• 2ITP · Crystal structure of EGFR kinase domain G719S mutation in complex with AEE788 · AEE A2019 · binds LEU718, VAL726, ALA743, ILE744, LYS745, MET766, LEU788, THR790 and 11 more
• 2ITT · Crystal structure of EGFR kinase domain L858R mutation in complex with AEE788 · AEE A2020 · binds LEU718, VAL726, ALA743, ILE744, LYS745, MET766, LEU788, THR790 and 10 more
• 2J6M · Crystal structure of EGFR kinase domain in complex with AEE788 · AEE A2021 · binds LEU718, VAL726, ALA743, ILE744, LYS745, GLU762, MET766, LEU788 and 12 more
• 2JIU · Crystal structure of EGFR kinase domain T790M mutation in complex with AEE788 · AEE A2017 · binds LEU718, VAL726, ALA743, ILE744, LYS745, LEU788, MET790, GLN791 and 10 more

Residues it binds most

LEU 8, MET 8, ASP 8, THR 8, GLU 8, ALA 8, GLN 8, GLY 8, ILE 8, LYS 8 (residue and the binding sites it lines).