MolNFT v1 · #42741 · protein
Heterodimeric association of transmembrane domains of ERBB1 and ERBB2 receptors enabling kinase activation
2KS1 · Receptor tyrosine-protein kinase erbb-2: “Heterodimeric association of transmembrane domains of ERBB1 and ERBB2 receptors enabling kinase activation”. Solution nmr. MolNFT v1 #42741 on GenesisL1: 3D structure, binding sites and…
- PDB
- 2KS1
- Type
- protein
- Length
- 88 residues
- Chains
- 2
- Method
- solution nmr
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Receptor tyrosine-protein kinase erbb-2; Epidermal growth factor receptor
- EC
- 2.7.10.1
- UniProt
- P04626, P00533
Structure
solution nmr · 2 distinct chains · 58% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Receptor tyrosine-protein kinase erbb-2 (EC 2.7.10.1) | protein | 44 | 66% helix, 0% strand | P04626 |
| B | Epidermal growth factor receptor (EC 2.7.10.1) | protein | 44 | 50% helix, 0% strand | P00533 |
Interfaces
1 interface between chains.
- A–B · 412 Ų buried · 1 hydrogen bond · protein-protein
Compared structures
- 2KS1 · Heterodimeric association of Transmembrane domains of ErbB1 and ErbB2 receptors Enabling… · the same entry in another collection · chain A against A, TM-score 1.00
- P04626 · AlphaFold monomer V2.0 prediction for receptor tyrosine-protein kinase erbb-2 (P04626) · a predicted model of the same protein · chain A against A, TM-score 0.61
- P00533 · AlphaFold monomer V2.0 prediction for epidermal growth factor receptor (P00533) · a predicted model of the same protein · chain B against A, TM-score 0.58
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P04626
- Every structure of UniProt P00533
- Elsewhere: RCSB PDB 2KS1 · PDBe 2KS1 · UniProt P04626 · UniProt P00533
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