UniProt P04626
Receptor tyrosine-protein kinase erbB-2 (P04626)
Receptor tyrosine-protein kinase erbB-2 (UniProt P04626), EC 2.7.10.1: 65 experimental structures and 1 predicted model on GenesisL1, 5 ligands bound, 13 pockets. Binding sites, druggability and experiment against prediction…
- UniProt
- P04626
- Protein
- Receptor tyrosine-protein kinase erbB-2
- EC
- 2.7.10.1
- Experimental structures
- 65
- Predicted models
- 1
- Ligands
- 5
- Pockets
- 13 · 3 records with a druggable one
Structures
66 records of P04626 in the MolNFT archive: 65 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1MW4 | Solution structure of the human Grb7-SH2 domain in complex with a 10 amino acid peptide pY1139 | solution nmr | B | — | — |
| 1MW4 | Solution structure of the human GRB7-SH2 domain in complex with a 10 amino acid peptide PY1139 | solution nmr | B | — | — |
| 1N8Z | Crystal structure of extracellular domain of human HER2 complexed with Herceptin Fab | x-ray diffraction | C | — | — |
| 1N8Z | Crystal structure of extracellular domain of human HER2 complexed with herceptin Fab | x-ray diffraction | C | — | — |
| 1QR1 | Poor binding of a her-2/NEU epitope (GP2) to HLA-A2.1 is due to a lack of interactions in the… | x-ray diffraction | C, F | — | — |
| 1QR1 | Poor binding of a her-2/NEU epitope (GP2) to HLA-A2.1 is due to a lack of interactions in the… | x-ray diffraction | C, F | — | — |
| 1S78 | Insights into ErbB signaling from the structure of the ErbB2-pertuzumab complex | x-ray diffraction | A, B | — | — |
| 1S78 | Insights into erbb signaling from the structure of the ERBB2- pertuzumab complex | x-ray diffraction | A, B | — | — |
| 2A91 | Crystal structure of ErbB2 domains 1-3 | x-ray diffraction | A | — | — |
| 2A91 | Crystal structure of ERBB2 domains 1-3 | x-ray diffraction | A | — | — |
| 2JWA | ErbB2 transmembrane segment dimer spatial structure | solution nmr | A, B | — | — |
| 2JWA | ERBB2 transmembrane segment dimer spatial structure | solution nmr | A, B | — | — |
| 2KS1 | Heterodimeric association of Transmembrane domains of ErbB1 and ErbB2 receptors Enabling Kinase… | solution nmr | A | — | — |
| 2KS1 | Heterodimeric association of transmembrane domains of ERBB1 and ERBB2 receptors enabling kinase… | solution nmr | A | — | — |
| 2L4K | Water refined solution structure of the human Grb7-SH2 domain in complex with the 10 amino acid… | solution nmr | B | — | — |
| 2L4K | Water refined solution structure of the human GRB7-SH2 domain in complex with the 10 amino acid… | solution nmr | B | — | — |
| 2N2A | Spatial structure of HER2/ErbB2 dimeric transmembrane domain in the presence of cytoplasmic… | solution nmr | A, B | — | — |
| 2N2A | Spatial structure of HER2/ERBB2 dimeric transmembrane domain in the presence of cytoplasmic… | solution nmr | A, B | — | — |
| 3BE1 | Dual specific bH1 Fab in complex with the extracellular domain of HER2/ErbB-2 | x-ray diffraction | A | — | — |
| 3BE1 | Dual specific BH1 Fab in complex with the extracellular domain of HER2/ERBB-2 | x-ray diffraction | A | — | — |
| 3H3B | Crystal structure of the single-chain Fv (scFv) fragment of an anti-ErbB2 antibody chA21 in complex… | x-ray diffraction | A, B | — | — |
| 3H3B | Crystal structure of the single-chain fv (scfv) fragment of an anti- ERBB2 antibody CHA21 in… | x-ray diffraction | A, B | — | — |
| 3MZW | HER2 extracelluar region with affinity matured 3-helix affibody ZHER2:342 | x-ray diffraction | A | — | — |
| 3MZW | HER2 extracelluar region with affinity matured 3-helix affibody ZHER2:342 | x-ray diffraction | A | — | — |
| 3N85 | Crystallographic trimer of HER2 extracellular regions in complex with tryptophan-rich antibody… | x-ray diffraction | A | — | — |
| 3N85 | Crystallographic trimer of HER2 extracellular regions in complex with tryptophan-rich antibody… | x-ray diffraction | A | — | — |
| 3PP0 | Crystal Structure of the Kinase domain of Human HER2 (erbB2). | x-ray diffraction | A, B | — | — |
| 3PP0 | Crystal structure of the kinase domain of human HER2 (ERBB2). | x-ray diffraction | A, B | — | — |
| 3RCD | HER2 Kinase Domain Complexed with TAK-285 | x-ray diffraction | A, B, C, D | — | — |
| 3RCD | HER2 kinase domain complexed with tak-285 | x-ray diffraction | A, B, C, D | — | — |
| 3WLW | Molecular Architecture of the ErbB2 Extracellular Domain Homodimer | x-ray diffraction | A, B | — | — |
| 3WLW | Molecular architecture of the ERBB2 extracellular domain homodimer | x-ray diffraction | A, B | — | — |
| 3WSQ | Structure of HER2 with an Fab | x-ray diffraction | A | — | — |
| 3WSQ | Structure of HER2 with an Fab | x-ray diffraction | A | — | — |
| 4HRL | Structural Basis for Eliciting a Cytotoxic Effect in HER2-Overexpressing Cancer Cells via Binding… | x-ray diffraction | C | — | — |
| 4HRL | Structural basis for eliciting a cytotoxic effect in HER2- overexpressing cancer cells via binding… | x-ray diffraction | C | — | — |
| 4HRM | Structural Basis for Eliciting a Cytotoxic Effect in HER2-Overexpressing Cancer Cells via Binding… | x-ray diffraction | C, A | — | — |
| 4HRM | Structural basis for eliciting a cytotoxic effect in HER2- overexpressing cancer cells via binding… | x-ray diffraction | C, A | — | — |
| 4HRN | Structural Basis for Eliciting a Cytotoxic Effect in HER2-Overexpressing Cancer Cells via Binding… | x-ray diffraction | C, D | — | — |
| 4HRN | Structural basis for eliciting a cytotoxic effect in HER2- overexpressing cancer cells via binding… | x-ray diffraction | C, D | — | — |
| 4NND | Structural basis of PTPN18 fingerprint on distinct HER2 tyrosine phosphorylation sites | x-ray diffraction | F, C, E, H | — | — |
| 4NND | Structural basis of PTPN18 fingerprint on distinct HER2 tyrosine phosphorylation sites | x-ray diffraction | F, C, E, H | — | — |
| 5K33 | Crystal structure of extracellular domain of HER2 in complex with fcab STAB19 | x-ray diffraction | C | NAG | — |
| 5KWG | Crystal structure of extracellular domain of HER2 in complex with Fcab H10-03-6 | x-ray diffraction | C | — | — |
| 5KWG | Crystal structure of extracellular domain of HER2 in complex with fcab H10-03-6 | x-ray diffraction | C | — | — |
| 5MY6 | Crystal structure of a HER2-Nb complex | x-ray diffraction | A | NAG | — |
| 5MY6 | Crystal structure of a HER2-nb complex | x-ray diffraction | A | NAG | — |
| 5O4G | HER2 in complex with Fab MF3958 | x-ray diffraction | C | NAG | — |
| 5O4G | HER2 in complex with Fab MF3958 | x-ray diffraction | C | NAG | — |
| 5OB4 | NMR spatial structure of HER2 tm domain dimer in dpc micelles. | solution nmr | A, B | — | — |
| 6ATT | 39S Fab bound to HER2 ecd | x-ray diffraction | A | NAG | — |
| 6BGT | Structure of trastuzumab Fab mutant in complex with HER2 extracellular domain | x-ray diffraction | C | NAG | — |
| 6J71 | HuA21-scFv in complex with the extracellular domain(ECD) of HER2 | x-ray diffraction | A | NAG, BMA | — |
| 6J71 | HUA21-scfv in complex with the extracellular DOMAIN(ECD) of HER2 | x-ray diffraction | A | NAG, BMA | — |
| 6LBX | Crystal structure of HER2 domain IV and rb-H2 | x-ray diffraction | B | NAG | — |
| 6OGE | Cryo-EM structure of HER2 extracellular domain-trastuzumab Fab- pertuzumab Fab complex | electron microscopy | A | NAG | — |
| 7JXH | HER2 in complex with jbj-08-178-01 | x-ray diffraction | B, A, C, D, E, F, G, H | VOY | — |
| 7MN5 | Structure of the HER2/HER3/NRG1B heterodimer extracellular domain | electron microscopy | B | NAG, MAN | — |
| 7MN6 | Structure of the HER2 S310F/HER3/NRG1B heterodimer extracellular domain | electron microscopy | B | NAG, MAN | — |
| 7MN8 | Structure of the HER2/HER3/NRG1b Heterodimer Extracellular Domain bound to Trastuzumab Fab | electron microscopy | B | NAG, MAN | — |
6 records more on the page itself.
Ligands
- NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · in 18 records
- MAN · alpha-D-mannopyranose · in 4 records
- BMA · beta-D-mannopyranose · in 2 records
- 70I · 1-[4-[4-[[3,5-bis(chloranyl)-4-([1,2,4]triazolo[1,5-a]pyridin-7-yloxy)phenyl]amino]pyrimido[5,4-d]pyrimidin-6-yl]piperazin-1-yl]-4-(3-fluoranylazetidin-1-yl)butan-1-one · in 1 record
- VOY · (2E)-N-[3-cyano-7-ethoxy-4-({3-methyl-4-[([1,2, 4]triazolo[1,5-a]pyridin-7-yl)oxy]phenyl}amino) quinolin-6-yl]-4-(dimethylamino)but-2-enamide · in 1 record
Experiment against prediction
- 8VQD chain A against the predicted model P04626: TM-score 0.99, RMSD 0.81 Å
- 8JYR chain A against the predicted model P04626: TM-score 0.99, RMSD 0.57 Å
- 4HRL chain C against the predicted model P04626: TM-score 0.99, RMSD 0.70 Å
- 4HRL chain C against the predicted model P04626: TM-score 0.99, RMSD 0.70 Å
- 6J71 chain A against the predicted model P04626: TM-score 0.99, RMSD 1.11 Å
- 6J71 chain A against the predicted model P04626: TM-score 0.99, RMSD 1.11 Å
- 2A91 chain A against the predicted model P04626: TM-score 0.98, RMSD 1.23 Å
- 2A91 chain A against the predicted model P04626: TM-score 0.98, RMSD 1.23 Å
- 3WSQ chain A against the predicted model P04626: TM-score 0.98, RMSD 1.20 Å
- 3WSQ chain A against the predicted model P04626: TM-score 0.98, RMSD 1.20 Å
Elsewhere
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