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Ligand · FMM

FMM · N-{3-chloro-4-[(3-fluorobenzyl)oxy]phenyl}-6-[5-({[2-(methylsulfonyl)ethyl]amino}methyl)-2-furyl]-4-quinazolinamine

FMM, N-{3-chloro-4-[(3-fluorobenzyl)oxy]phenyl}-6-[5-({[2-(methylsulfonyl)ethyl]amino}methyl)-2-furyl]-4-quinazolinamine (C29 H26 Cl F N4 O4 S, 581.1 g/mol), in the MolNFT structures on GenesisL1: bound in 4 records (2 PDB entries). Every…

Component
FMM
Formula
C29 H26 Cl F N4 O4 S
Class
ligand
Structures
4
PDB entries
2

Binding sites

FMM in 4 structures; the first of them:

  • 1XKK · EGFR kinase domain complexed with a quinazoline inhibitor- GW572016 · FMM A91 · binds LEU718, GLY719, VAL726, ALA743, ILE744, LYS745, MET766, CYS775 and 20 more
  • 3BBT · crystal structure of the ErbB4 kinase in complex with lapatinib · FMM B91 · binds LEU699, VAL707, ALA724, ILE725, LYS726, MET747, VAL756, LEU758 and 11 more
  • 1XKK · EGFR kinase domain complexed with a quinazoline inhibitor- GW572016 · FMM A91 · binds LEU718, GLY719, VAL726, ALA743, ILE744, LYS745, MET766, CYS775 and 20 more
  • 3BBT · Crystal structure of the ERBB4 kinase in complex with lapatinib · FMM B91 · binds LEU699, VAL707, ALA724, ILE725, LYS726, MET747, VAL756, LEU758 and 11 more

Residues it binds most

LEU 6, MET 6, THR 6, VAL 6, ASP 6, CYS 6, GLY 6, ILE 6, ALA 6, ARG 2 (residue and the binding sites it lines).

Found with

  • PO4 · Phosphate ion

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