MolNFT v1 · #14181 · protein
Tyrosine kinase domain from epidermal growth factor receptor
1M14: “Tyrosine kinase domain from epidermal growth factor receptor”. X-ray diffraction, 3 pockets (best druggability 0.63). MolNFT v1 #14181 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 1M14
- Type
- protein
- Length
- 307 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Epidermal growth factor receptor
- EC
- 2.7.1.112
- UniProt
- P00533
- Pockets
- 3 · best druggability 0.63
Structure
x-ray diffraction · 1 distinct chain · 38% helix, 19% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Epidermal growth factor receptor (EC 2.7.1.112) | protein | 307 | 38% helix, 19% strand | P00533 |
Pockets
3 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 291 | 0.63 | 0.80 | 30 | empty |
| 2 | 215 | 0.54 | 0.77 | 36 | empty |
| 3 | 50 | 0.26 | 0.74 | 18 | empty |
Compared structures
- 1M14 · Tyrosine Kinase Domain from Epidermal Growth Factor Receptor · the same entry in another collection · chain A against A, TM-score 1.00
- P00533 · AlphaFold monomer V2.0 prediction for epidermal growth factor receptor (P00533) · a predicted model of the same protein · chain A against A, TM-score 0.90
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P00533
- Elsewhere: RCSB PDB 1M14 · PDBe 1M14 · UniProt P00533
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