Ligand · 5X4
5X4 · ~{N}-[7-methyl-1-[(3~{R})-1-propanoylazepan-3-yl]benzimidazol-2-yl]-3-(trifluoromethyl)benzamide
5X4, ~{N}-[7-methyl-1-[(3~{R})-1-propanoylazepan-3-yl]benzimidazol-2-yl]-3-(trifluoromethyl)benzamide (C25 H27 F3 N4 O2, 472.5 g/mol), in the MolNFT structures on GenesisL1: bound in 4 records (2 PDB entries). Every binding site with its…
- Component
- 5X4
- Formula
- C25 H27 F3 N4 O2
- Class
- ligand
- Structures
- 4
- PDB entries
- 2
Binding sites
5X4 in 4 structures; the first of them:
- 5FED · EGFR kinase domain in complex with a covalent aminobenzimidazole inhibitor. · 5X4 A1101 · binds LEU718, GLY719, VAL726, ALA743, LYS745, CYS775, THR790, GLN791 and 10 more
- 5FEE · EGFR kinase domain T790M mutant in complex with a covalent aminobenzimidazole inhibitor. · 5X4 A1101 · binds LEU718, GLY719, VAL726, ALA743, LYS745, CYS775, MET790, GLN791 and 11 more
- 5FED · EGFR kinase domain in complex with a covalent aminobenzimidazole inhibitor. · 5X4 A1101 · binds LEU718, GLY719, VAL726, ALA743, LYS745, CYS775, THR790, GLN791 and 10 more
- 5FEE · EGFR kinase domain T790M mutant in complex with a covalent aminobenzimidazole inhibitor. · 5X4 A1101 · binds LEU718, GLY719, VAL726, ALA743, LYS745, CYS775, MET790, GLN791 and 11 more
Residues it binds most
LEU 4, CYS 4, GLY 4, ASP 4, MET 4, THR 4, ALA 4, ARG 4, GLN 4, LYS 4 (residue and the binding sites it lines).
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