MolNFT v1 · #157450 · protein
Human tfiid canonical state
6MZL · Transcription initiation factor tfiid subunit 1: “Human tfiid canonical state”. Electron microscopy, 20 pockets (best druggability 0.89). MolNFT v1 #157450 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 6MZL
- Type
- protein
- Length
- 4,844 residues
- Chains
- 22
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Transcription initiation factor tfiid subunit 1; Transcription initiation factor tfiid…
- EC
- 2.3.1.48, 2.7.11.1
- UniProt
- P21675, Q6P1X5, Q5VWG9, O00268, Q15542, P49848, Q15545, Q7Z7C8, Q16594, Q12962, Q15544, Q16514, Q15543, P20226
- Pockets
- 20 · best druggability 0.89
Structure
electron microscopy · 17 distinct chains · 43% helix, 12% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Transcription initiation factor tfiid subunit 1 (EC 2.3.1.48, 2.7.11.1) | protein | 472 | 33% helix, 15% strand | P21675 |
| B | Transcription initiation factor tfiid subunit 2 | protein | 968 | 37% helix, 14% strand | Q6P1X5 |
| C | Transcription initiation factor tfiid subunit 3 | protein | 93 | 68% helix, 2% strand | Q5VWG9 |
| D, E | Transcription initiation factor tfiid subunit 4 | protein | 102 | 72% helix, 1% strand | O00268 |
| F, G | Transcription initiation factor tfiid subunit 5,TAF5 | protein | 473 | 20% helix, 27% strand | Q15542 |
| H | Transcription initiation factor tfiid subunit 6 | protein | 329 | 70% helix, 0% strand | P49848 |
| I | Transcription initiation factor tfiid subunit 6 | protein | 339 | 69% helix, 1% strand | P49848 |
| J | Transcription initiation factor tfiid subunit 7 | protein | 123 | 18% helix, 42% strand | Q15545 |
| K | Transcription initiation factor tfiid subunit 8,TAF8 | protein | 202 | 47% helix, 1% strand | Q7Z7C8 |
| L, M | Transcription initiation factor tfiid subunit 9, TAF9 | protein | 104 | 65% helix, 0% strand | Q16594 |
| N, O | Transcription initiation factor tfiid subunit 10 | protein | 82 | 60% helix, 2% strand | Q12962 |
| P | Transcription initiation factor tfiid subunit 11 | protein | 89 | 69% helix, 0% strand | Q15544 |
| Q, R | Transcription initiation factor tfiid subunit 12 | protein | 74 | 66% helix, 1% strand | Q16514 |
| S | Transcription initiation factor tfiid subunit 13 | protein | 45 | 67% helix, 0% strand | Q15543 |
| T | Tata-box-binding protein | protein | 180 | 27% helix, 40% strand | P20226 |
| Y | POLY(UNK) | protein | 96 | 32% helix, 1% strand | — |
| Z | POLY(UNK) | protein | 238 | 29% helix, 1% strand | — |
Pockets
20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1000 | 0.89 | 0.90 | 128 | empty |
| 2 | 1012 | 0.87 | 0.88 | 106 | empty |
| 3 | 1140 | 0.83 | 0.85 | 138 | empty |
| 4 | 763 | 0.82 | 0.85 | 96 | empty |
| 5 | 571 | 0.81 | 0.87 | 55 | empty |
Interfaces
58 interfaces between chains.
- A–J · 3963 Ų buried · 60 hydrogen bonds · protein-protein
- K–O · 2384 Ų buried · 20 hydrogen bonds · protein-protein
- C–N · 2364 Ų buried · 18 hydrogen bonds · protein-protein
- B–K · 2221 Ų buried · 12 hydrogen bonds · protein-protein
- A–T · 2139 Ų buried · 23 hydrogen bonds · protein-protein
Compared structures
- 6MZL · Human TFIID canonical state · the same entry in another collection · chain J against J, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P21675
- Every structure of UniProt Q6P1X5
- Every structure of UniProt Q5VWG9
- Every structure of UniProt O00268
- Every structure of UniProt Q15542
- Every structure of UniProt P49848
- Every structure of UniProt Q15545
- Every structure of UniProt Q7Z7C8
- Every structure of UniProt Q16594
- Every structure of UniProt Q12962
- Every structure of UniProt Q15544
- Every structure of UniProt Q16514
- Every structure of UniProt Q15543
- Every structure of UniProt P20226
- Elsewhere: RCSB PDB 6MZL · PDBe 6MZL · UniProt P21675 · UniProt Q6P1X5 · UniProt Q5VWG9 · UniProt O00268 · UniProt Q15542 · UniProt P49848 · UniProt Q15545 · UniProt Q7Z7C8 · UniProt Q16594 · UniProt Q12962 · UniProt Q15544 · UniProt Q16514 · UniProt Q15543 · UniProt P20226
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