UniProt Q5VWG9

Transcription initiation factor TFIID subunit 3 (Q5VWG9)

Transcription initiation factor TFIID subunit 3 (UniProt Q5VWG9): 44 experimental structures and 1 predicted model on GenesisL1, 2 ligands bound, 55 pockets. Binding sites, druggability and experiment against prediction…

UniProt: Q5VWG9
Protein: Transcription initiation factor TFIID subunit 3
Experimental structures: 44
Predicted models: 1
Ligands: 2
Pockets: 55 · 21 records with a druggable one

Structures

45 records of Q5VWG9 in the MolNFT archive: 44 experimental, 1 predicted.

Entry	Title	Method	Chains	Ligands	Pockets
5C13	Crystal Structure of TAF3 PHD finger bound to histone H3C4me3 peptide	x-ray diffraction	A, C, E, G	ZN	2 (best 0.39)
5C13	Crystal structure of TAF3 phd finger bound to histone H3C4ME3 peptide	x-ray diffraction	A, C, E, G	—	—
5WXG	Structure of TAF PHD finger domain binds to H3(1-15)K4ac	x-ray diffraction	A	ZN, MG	—
5WXG	Structure of taf phd finger domain binds to H3(1-15)K4AC	x-ray diffraction	A	ZN, MG	—
5WXH	Crystal structure of TAF3 PHD finger bound to H3K4me3	x-ray diffraction	A, C	ZN	1 (best 0.60)
5WXH	Crystal structure of TAF3 phd finger bound to H3K4ME3	x-ray diffraction	A, C	ZN	—
5XMY	Crystal structure of TAF3 PHD finger bound to H3K4me3Q5ser	x-ray diffraction	A, C	ZN	1 (best 0.57)
5XMY	Crystal structure of TAF3 phd finger bound to H3K4ME3Q5SER	x-ray diffraction	A, C	ZN	—
6MZD	Human TFIID Lobe A canonical	electron microscopy	C	—	9 (best 0.87)
6MZD	Human tfiid lobe a canonical	electron microscopy	C	—	—
6MZL	Human TFIID canonical state	electron microscopy	C	—	2 (best 0.87)
6MZL	Human tfiid canonical state	electron microscopy	C	—	—
7EDX	p53-bound TFIID-based core PIC on HDM2 promoter	electron microscopy	c	—	2 (best 0.85)
7EDX	P53-bound tfiid-based core pic on HDM2 promoter	electron microscopy	c	—	—
7EG7	TFIID-based core PIC on SCP promoter	electron microscopy	c	—	2 (best 0.87)
7EG7	Tfiid-based core pic on scp promoter	electron microscopy	c	—	—
7EG8	TFIID-based core PIC on PUMA promoter	electron microscopy	c	—	2 (best 0.87)
7EG8	Tfiid-based core pic on puma promoter	electron microscopy	c	—	—
7EG9	TFIID-based intermediate PIC on SCP promoter	electron microscopy	c	—	2 (best 0.86)
7EG9	Tfiid-based intermediate pic on scp promoter	electron microscopy	c	—	—
7EGA	TFIID-based intermediate PIC on PUMA promoter	electron microscopy	c	—	—
7EGA	Tfiid-based intermediate pic on puma promoter	electron microscopy	c	—	—
7EGB	TFIID-based holo PIC on SCP promoter	electron microscopy	c	—	1 (best 0.86)
7EGC	p53-bound TFIID-based holo PIC on HDM2 promoter	electron microscopy	c	—	—
7EGD	Scp promoter-bound tfiid-tfiia in initial tbp-loading state	electron microscopy	c	—	—
7EGE	TFIID in canonical conformation	electron microscopy	c	—	4 (best 0.86)
7EGE	Tfiid in canonical conformation	electron microscopy	c	—	—
7EGF	TFIID lobe A subcomplex	electron microscopy	c	—	—
7EGF	Tfiid lobe a subcomplex	electron microscopy	c	—	—
7EGI	TFIID in rearranged conformation	electron microscopy	c	—	4 (best 0.86)
7EGI	Tfiid in rearranged conformation	electron microscopy	c	—	—
7EGJ	Scp promoter-bound tfiid-tfiia in post tbp-loading state	electron microscopy	c	—	—
7ENA	TFIID-based PIC-Mediator holo-complex in pre-assembled state (pre-hPIC-MED)	electron microscopy	Dc	—	—
7ENC	TFIID-based PIC-Mediator holo-complex in fully-assembled state (hPIC-MED)	electron microscopy	Dc	—	—
8GXQ	PIC-Mediator in complex with +1 nucleosome (T40N) in MH-binding state	electron microscopy	Dc	—	3 (best 0.86)
8GXS	PIC-Mediator in complex with +1 nucleosome (T40N) in H-binding state	electron microscopy	Dc	—	3 (best 0.88)
8WAK	Structure of transcribing complex 2 (TC2), the initially transcribing complex with Pol II…	electron microscopy	c	—	2 (best 0.86)
8WAL	Structure of transcribing complex 3 (TC3), the initially transcribing complex with Pol II…	electron microscopy	c	—	2 (best 0.86)
8WAN	Structure of transcribing complex 4 (TC4), the initially transcribing complex with Pol II…	electron microscopy	c	—	2 (best 0.86)
8WAO	Structure of transcribing complex 5 (TC5), the initially transcribing complex with Pol II…	electron microscopy	c	—	2 (best 0.87)
8WAP	Structure of transcribing complex 6 (TC6), the initially transcribing complex with Pol II…	electron microscopy	c	—	2 (best 0.86)
8WAQ	Structure of transcribing complex 7 (TC7), the initially transcribing complex with Pol II…	electron microscopy	c	—	2 (best 0.86)
8WAR	Structure of transcribing complex 8 (TC8), the initially transcribing complex with Pol II…	electron microscopy	c	—	2 (best 0.86)
8WAS	Structure of transcribing complex 9 (TC9), the initially transcribing complex with Pol II…	electron microscopy	c	—	2 (best 0.86)
Q5VWG9	AlphaFold monomer V2.0 prediction for transcription initiation factor tfiid subunit 3 (Q5VWG9)	predicted	A	—	1 (best 0.47)

Ligands

ZN · Zinc ion · in 7 records
MG · Magnesium ion · in 2 records

Experiment against prediction

5XMY chain A against the predicted model Q5VWG9: TM-score 0.90, RMSD 1.22 Å
5XMY chain A against the predicted model Q5VWG9: TM-score 0.90, RMSD 1.22 Å
5WXG chain A against the predicted model Q5VWG9: TM-score 0.89, RMSD 1.30 Å
5WXG chain A against the predicted model Q5VWG9: TM-score 0.89, RMSD 1.30 Å
5C13 chain A against the predicted model Q5VWG9: TM-score 0.89, RMSD 1.19 Å
5C13 chain A against the predicted model Q5VWG9: TM-score 0.89, RMSD 1.19 Å
5WXH chain A against the predicted model Q5VWG9: TM-score 0.89, RMSD 1.16 Å
5WXH chain A against the predicted model Q5VWG9: TM-score 0.89, RMSD 1.16 Å
7EG9 chain c against the predicted model Q5VWG9: TM-score 0.86, RMSD 2.35 Å
7EG9 chain c against the predicted model Q5VWG9: TM-score 0.86, RMSD 2.35 Å

Elsewhere

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