UniProt Q12962
Transcription initiation factor TFIID subunit 10 (Q12962)
Transcription initiation factor TFIID subunit 10 (UniProt Q12962): 35 experimental structures and 1 predicted model on GenesisL1, 12 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- Q12962
- Protein
- Transcription initiation factor TFIID subunit 10
- Experimental structures
- 35
- Predicted models
- 1
- Pockets
- 12 · 3 records with a druggable one
Structures
36 records of Q12962 in the MolNFT archive: 35 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 4J7F | SET7/9Y335pAF in complex with TAF10 peptide and AdoHcy | x-ray diffraction | B | — | — |
| 4J7F | SET7/9Y335PAF in complex with TAF10 peptide and adohcy | x-ray diffraction | B | — | — |
| 4J7I | SET7/9Y335F in complex with TAF10 peptide and AdoHcy | x-ray diffraction | B | — | — |
| 4J7I | SET7/9Y335F in complex with TAF10 peptide and adohcy | x-ray diffraction | B | — | — |
| 4J83 | SET7/9 in complex with TAF10K189A peptide and AdoMet | x-ray diffraction | B | — | — |
| 4J83 | SET7/9 in complex with TAF10K189A peptide and adomet | x-ray diffraction | B | — | — |
| 4J8O | SET7/9 in complex with TAF10K189A peptide and AdoHcy | x-ray diffraction | B | — | — |
| 4J8O | SET7/9 in complex with TAF10K189A peptide and adohcy | x-ray diffraction | B | — | — |
| 4WV4 | Heterodimer of TAF8/TAF10 | x-ray diffraction | A | — | — |
| 5EG2 | SET7/9 N265A in complex with AdoHcy and TAF10 peptide | x-ray diffraction | B | — | — |
| 5EG2 | SET7/9 N265A in complex with adohcy and TAF10 peptide | x-ray diffraction | B | — | — |
| 6MZC | Human tfiid bc core | electron microscopy | O | — | — |
| 6MZD | Human tfiid lobe a canonical | electron microscopy | N | — | — |
| 6MZL | Human tfiid canonical state | electron microscopy | N, O | — | — |
| 6MZM | Human tfiid bound to promoter DNA and tfiia | electron microscopy | O | — | — |
| 7EDX | P53-bound tfiid-based core pic on HDM2 promoter | electron microscopy | J, j | — | — |
| 7EG7 | Tfiid-based core pic on scp promoter | electron microscopy | J, j | — | — |
| 7EG8 | Tfiid-based core pic on puma promoter | electron microscopy | J, j | — | — |
| 7EG9 | Tfiid-based intermediate pic on scp promoter | electron microscopy | J, j | — | — |
| 7EGA | TFIID-based intermediate PIC on PUMA promoter | electron microscopy | J, j | — | — |
| 7EGA | Tfiid-based intermediate pic on puma promoter | electron microscopy | J, j | — | — |
| 7EGC | p53-bound TFIID-based holo PIC on HDM2 promoter | electron microscopy | J, j | — | — |
| 7EGD | Scp promoter-bound tfiid-tfiia in initial tbp-loading state | electron microscopy | J, j | — | — |
| 7EGE | Tfiid in canonical conformation | electron microscopy | J, j | — | — |
| 7EGF | TFIID lobe A subcomplex | electron microscopy | j | — | — |
| 7EGF | Tfiid lobe a subcomplex | electron microscopy | j | — | — |
| 7EGG | Tfiid lobe B subcomplex | electron microscopy | J | — | — |
| 7EGI | TFIID in rearranged conformation | electron microscopy | J, j | — | 6 (best 0.86) |
| 7EGI | Tfiid in rearranged conformation | electron microscopy | J, j | — | — |
| 7EGJ | Scp promoter-bound tfiid-tfiia in post tbp-loading state | electron microscopy | J, j | — | — |
| 7ENA | TFIID-based PIC-Mediator holo-complex in pre-assembled state (pre-hPIC-MED) | electron microscopy | DJ, Dj | — | — |
| 7ENC | TFIID-based PIC-Mediator holo-complex in fully-assembled state (hPIC-MED) | electron microscopy | DJ, Dj | — | — |
| 7KTR | Cryo-EM structure of the human saga coactivator complex (trrap, core) | electron microscopy | H | — | — |
| 7KTS | Negative stain EM structure of the human SAGA coactivator complex (TRRAP, core, splicing module) | electron microscopy | H | — | 3 (best 0.88) |
| 8WAQ | Structure of transcribing complex 7 (TC7), the initially transcribing complex with Pol II… | electron microscopy | J, j | — | 3 (best 0.86) |
| Q12962 | AlphaFold monomer V2.0 prediction for transcription initiation factor tfiid subunit 10 (Q12962) | predicted | A | — | — |
Experiment against prediction
- 7EDX chain J against the predicted model Q12962: TM-score 0.89, RMSD 1.55 Å
- 7EG7 chain J against the predicted model Q12962: TM-score 0.89, RMSD 1.55 Å
- 7EG8 chain J against the predicted model Q12962: TM-score 0.89, RMSD 1.58 Å
- 7EGA chain J against the predicted model Q12962: TM-score 0.89, RMSD 1.58 Å
- 7EGA chain J against the predicted model Q12962: TM-score 0.89, RMSD 1.58 Å
- 7EG9 chain J against the predicted model Q12962: TM-score 0.89, RMSD 1.58 Å
- 8WAQ chain J against the predicted model Q12962: TM-score 0.89, RMSD 1.74 Å
- 7EGJ chain J against the predicted model Q12962: TM-score 0.89, RMSD 1.74 Å
- 7EGG chain J against the predicted model Q12962: TM-score 0.89, RMSD 1.74 Å
- 7EGE chain J against the predicted model Q12962: TM-score 0.89, RMSD 1.74 Å
Elsewhere
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