UniProt Q16514
Transcription initiation factor TFIID subunit 12 (Q16514)
Transcription initiation factor TFIID subunit 12 (UniProt Q16514): 32 experimental structures and 1 predicted model on GenesisL1, 34 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- Q16514
- Protein
- Transcription initiation factor TFIID subunit 12
- Experimental structures
- 32
- Predicted models
- 1
- Pockets
- 34 · 9 records with a druggable one
Structures
33 records of Q16514 in the MolNFT archive: 32 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1H3O | Crystal Structure of the Human TAF4-TAF12 (TAFII135-TAFII20) Complex | x-ray diffraction | B, D | — | — |
| 1H3O | Crystal structure of the human TAF4-TAF12 (TAFII135-TAFII20) complex | x-ray diffraction | B, D | — | — |
| 6MZC | Human tfiid bc core | electron microscopy | R | — | — |
| 6MZD | Human tfiid lobe a canonical | electron microscopy | Q | — | — |
| 6MZL | Human TFIID canonical state | electron microscopy | Q, R | — | 3 (best 0.83) |
| 6MZL | Human tfiid canonical state | electron microscopy | Q, R | — | — |
| 6MZM | Human TFIID bound to promoter DNA and TFIIA | electron microscopy | R | — | 2 (best 0.75) |
| 6MZM | Human tfiid bound to promoter DNA and tfiia | electron microscopy | R | — | — |
| 7EDX | p53-bound TFIID-based core PIC on HDM2 promoter | electron microscopy | L, l | — | 4 (best 0.86) |
| 7EDX | P53-bound tfiid-based core pic on HDM2 promoter | electron microscopy | L, l | — | — |
| 7EG7 | Tfiid-based core pic on scp promoter | electron microscopy | L, l | — | — |
| 7EG8 | Tfiid-based core pic on puma promoter | electron microscopy | L, l | — | — |
| 7EG9 | Tfiid-based intermediate pic on scp promoter | electron microscopy | L, l | — | — |
| 7EGA | TFIID-based intermediate PIC on PUMA promoter | electron microscopy | L, l | — | — |
| 7EGA | Tfiid-based intermediate pic on puma promoter | electron microscopy | L, l | — | — |
| 7EGB | TFIID-based holo PIC on SCP promoter | electron microscopy | L, l | — | 4 (best 0.86) |
| 7EGC | p53-bound TFIID-based holo PIC on HDM2 promoter | electron microscopy | L, l | — | — |
| 7EGD | Scp promoter-bound tfiid-tfiia in initial tbp-loading state | electron microscopy | L, l | — | — |
| 7EGE | Tfiid in canonical conformation | electron microscopy | L, l | — | — |
| 7EGF | TFIID lobe A subcomplex | electron microscopy | l | — | — |
| 7EGF | Tfiid lobe a subcomplex | electron microscopy | l | — | — |
| 7EGG | Tfiid lobe B subcomplex | electron microscopy | L | — | — |
| 7EGI | TFIID in rearranged conformation | electron microscopy | L, l | — | 5 (best 0.86) |
| 7EGI | Tfiid in rearranged conformation | electron microscopy | L, l | — | — |
| 7EGJ | Scp promoter-bound tfiid-tfiia in post tbp-loading state | electron microscopy | L, l | — | — |
| 7ENA | TFIID-based PIC-Mediator holo-complex in pre-assembled state (pre-hPIC-MED) | electron microscopy | DL, Dl | — | — |
| 7ENC | TFIID-based PIC-Mediator holo-complex in fully-assembled state (hPIC-MED) | electron microscopy | DL, Dl | — | — |
| 7KTR | Cryo-EM structure of the human saga coactivator complex (trrap, core) | electron microscopy | G | — | — |
| 7KTS | Negative stain EM structure of the human SAGA coactivator complex (TRRAP, core, splicing module) | electron microscopy | G | — | 5 (best 0.88) |
| 8GXQ | PIC-Mediator in complex with +1 nucleosome (T40N) in MH-binding state | electron microscopy | Dl, DL | — | 4 (best 0.86) |
| 8WAO | Structure of transcribing complex 5 (TC5), the initially transcribing complex with Pol II… | electron microscopy | L, l | — | 3 (best 0.87) |
| 8WAQ | Structure of transcribing complex 7 (TC7), the initially transcribing complex with Pol II… | electron microscopy | L, l | — | 4 (best 0.86) |
| Q16514 | AlphaFold monomer V2.0 prediction for transcription initiation factor tfiid subunit 12 (Q16514) | predicted | A | — | — |
Experiment against prediction
- 1H3O chain B against the predicted model Q16514: TM-score 0.95, RMSD 0.75 Å
- 1H3O chain B against the predicted model Q16514: TM-score 0.95, RMSD 0.75 Å
- 7EGI chain L against the predicted model Q16514: TM-score 0.94, RMSD 0.85 Å
- 7EGI chain L against the predicted model Q16514: TM-score 0.94, RMSD 0.85 Å
- 7EGD chain L against the predicted model Q16514: TM-score 0.94, RMSD 0.85 Å
- 7EGJ chain L against the predicted model Q16514: TM-score 0.94, RMSD 0.85 Å
- 7EGB chain L against the predicted model Q16514: TM-score 0.94, RMSD 0.85 Å
- 7EGE chain L against the predicted model Q16514: TM-score 0.94, RMSD 0.85 Å
- 7EGG chain L against the predicted model Q16514: TM-score 0.94, RMSD 0.85 Å
- 8WAQ chain L against the predicted model Q16514: TM-score 0.94, RMSD 0.85 Å
Elsewhere
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