MolNFT v1 · #177371 · protein
Tfiid lobe B subcomplex
7EGG · Transcription initiation factor tfiid subunit 4: “Tfiid lobe B subcomplex”. Electron microscopy, 15 pockets (best druggability 0.86). MolNFT v1 #177371 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 7EGG
- Type
- protein
- Length
- 1,259 residues
- Chains
- 7
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Transcription initiation factor tfiid subunit 4; Transcription initiation factor tfiid…
- UniProt
- O00268, Q15542, P49848, Q7Z7C8, Q16594, Q12962, Q16514
- Pockets
- 15 · best druggability 0.86
Structure
electron microscopy · 7 distinct chains · 40% helix, 15% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| D | Transcription initiation factor tfiid subunit 4 | protein | 155 | 60% helix, 4% strand | O00268 |
| E | Transcription initiation factor tfiid subunit 5 | protein | 547 | 24% helix, 30% strand | Q15542 |
| F | Transcription initiation factor tfiid subunit 6 | protein | 145 | 35% helix, 10% strand | P49848 |
| H | Transcription initiation factor tfiid subunit 8 | protein | 126 | 50% helix, 1% strand | Q7Z7C8 |
| I | Transcription initiation factor tfiid subunit 9 | protein | 120 | 51% helix, 4% strand | Q16594 |
| J | Transcription initiation factor tfiid subunit 10 | protein | 90 | 58% helix, 3% strand | Q12962 |
| L | Transcription initiation factor tfiid subunit 12 | protein | 76 | 64% helix, 4% strand | Q16514 |
Pockets
15 pockets found on a 1 Å grid, 8 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 961 | 0.86 | 0.87 | 107 | empty |
| 2 | 1154 | 0.85 | 0.86 | 112 | empty |
| 3 | 1079 | 0.80 | 0.81 | 120 | empty |
| 4 | 528 | 0.79 | 0.86 | 58 | empty |
| 5 | 79 | 0.74 | 0.98 | 22 | empty |
Interfaces
18 interfaces between chains.
- E–F · 2486 Ų buried · 20 hydrogen bonds · protein-protein
- D–L · 2453 Ų buried · 17 hydrogen bonds · protein-protein
- F–I · 2411 Ų buried · 22 hydrogen bonds · protein-protein
- H–J · 2374 Ų buried · 12 hydrogen bonds · protein-protein
- F–H · 2060 Ų buried · 22 hydrogen bonds · protein-protein
Compared structures
- 7EGG · TFIID lobe B subcomplex · the same entry in another collection · chain L against L, TM-score 1.00
- Q15542 · AlphaFold monomer V2.0 prediction for transcription initiation factor tfiid subunit 5… · a predicted model of the same protein · chain E against A, TM-score 0.94
- Q16514 · AlphaFold monomer V2.0 prediction for transcription initiation factor tfiid subunit 12… · a predicted model of the same protein · chain L against A, TM-score 0.94
- Q12962 · AlphaFold monomer V2.0 prediction for transcription initiation factor tfiid subunit 10… · a predicted model of the same protein · chain J against A, TM-score 0.89
- Q16594 · AlphaFold monomer V2.0 prediction for transcription initiation factor tfiid subunit 9… · a predicted model of the same protein · chain I against A, TM-score 0.87
- Q7Z7C8 · AlphaFold monomer V2.0 prediction for transcription initiation factor tfiid subunit 8… · a predicted model of the same protein · chain H against A, TM-score 0.78
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O00268
- Every structure of UniProt Q15542
- Every structure of UniProt P49848
- Every structure of UniProt Q7Z7C8
- Every structure of UniProt Q16594
- Every structure of UniProt Q12962
- Every structure of UniProt Q16514
- Elsewhere: RCSB PDB 7EGG · PDBe 7EGG · UniProt O00268 · UniProt Q15542 · UniProt P49848 · UniProt Q7Z7C8 · UniProt Q16594 · UniProt Q12962 · UniProt Q16514
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