UniProt Q7Z7C8
Transcription initiation factor TFIID subunit 8 (Q7Z7C8)
Transcription initiation factor TFIID subunit 8 (UniProt Q7Z7C8): 45 experimental structures and 1 predicted model on GenesisL1, 1 ligand bound, 95 pockets. Binding sites, druggability and experiment against prediction (TM-score)…
- UniProt
- Q7Z7C8
- Protein
- Transcription initiation factor TFIID subunit 8
- Experimental structures
- 45
- Predicted models
- 1
- Ligands
- 1
- Pockets
- 95 · 28 records with a druggable one
Structures
46 records of Q7Z7C8 in the MolNFT archive: 45 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 4WV4 | Heterodimer of TAF8/TAF10 | x-ray diffraction | B | CL | 1 (best 0.28) |
| 4WV6 | Heterodimer of Importin alpha 1 with nuclear localization signal of TAF8 | x-ray diffraction | B, C | — | — |
| 4WV6 | Heterodimer of importin alpha 1 with nuclear localization signal of TAF8 | x-ray diffraction | B, C | — | — |
| 5FUR | Structure of human TFIID-IIA bound to core promoter DNA | electron microscopy | L | — | 1 (best 0.75) |
| 5FUR | Structure of human tfiid-iia bound to core promoter DNA | electron microscopy | L | — | 1 (best 0.75) |
| 6MZC | Human TFIID BC core | electron microscopy | K | — | 5 (best 0.74) |
| 6MZC | Human tfiid bc core | electron microscopy | K | — | — |
| 6MZL | Human TFIID canonical state | electron microscopy | K | — | 3 (best 0.83) |
| 6MZL | Human tfiid canonical state | electron microscopy | K | — | — |
| 6MZM | Human TFIID bound to promoter DNA and TFIIA | electron microscopy | K | — | 7 (best 0.88) |
| 6MZM | Human tfiid bound to promoter DNA and tfiia | electron microscopy | K | — | — |
| 7EDX | p53-bound TFIID-based core PIC on HDM2 promoter | electron microscopy | H | — | 3 (best 0.86) |
| 7EDX | P53-bound tfiid-based core pic on HDM2 promoter | electron microscopy | H | — | — |
| 7EG7 | TFIID-based core PIC on SCP promoter | electron microscopy | H | — | 3 (best 0.87) |
| 7EG7 | Tfiid-based core pic on scp promoter | electron microscopy | H | — | — |
| 7EG8 | TFIID-based core PIC on PUMA promoter | electron microscopy | H | — | 4 (best 0.89) |
| 7EG8 | Tfiid-based core pic on puma promoter | electron microscopy | H | — | — |
| 7EG9 | TFIID-based intermediate PIC on SCP promoter | electron microscopy | H | — | 4 (best 0.88) |
| 7EG9 | Tfiid-based intermediate pic on scp promoter | electron microscopy | H | — | — |
| 7EGA | TFIID-based intermediate PIC on PUMA promoter | electron microscopy | H | — | 4 (best 0.87) |
| 7EGA | Tfiid-based intermediate pic on puma promoter | electron microscopy | H | — | — |
| 7EGB | TFIID-based holo PIC on SCP promoter | electron microscopy | H | — | 4 (best 0.86) |
| 7EGC | p53-bound TFIID-based holo PIC on HDM2 promoter | electron microscopy | H | — | 3 (best 0.85) |
| 7EGD | Scp promoter-bound tfiid-tfiia in initial tbp-loading state | electron microscopy | H | — | — |
| 7EGE | TFIID in canonical conformation | electron microscopy | H | — | 6 (best 0.84) |
| 7EGE | Tfiid in canonical conformation | electron microscopy | H | — | — |
| 7EGG | TFIID lobe B subcomplex | electron microscopy | H | — | 8 (best 0.86) |
| 7EGG | Tfiid lobe B subcomplex | electron microscopy | H | — | — |
| 7EGH | TFIID lobe C subcomplex | electron microscopy | H | — | 5 (best 0.77) |
| 7EGH | Tfiid lobe C subcomplex | electron microscopy | H | — | — |
| 7EGI | TFIID in rearranged conformation | electron microscopy | H | — | 6 (best 0.84) |
| 7EGI | Tfiid in rearranged conformation | electron microscopy | H | — | — |
| 7EGJ | Scp promoter-bound tfiid-tfiia in post tbp-loading state | electron microscopy | H | — | — |
| 7ENA | TFIID-based PIC-Mediator holo-complex in pre-assembled state (pre-hPIC-MED) | electron microscopy | DH | — | 2 (best 0.86) |
| 7ENC | TFIID-based PIC-Mediator holo-complex in fully-assembled state (hPIC-MED) | electron microscopy | DH | — | 1 (best 0.83) |
| 8GXQ | PIC-Mediator in complex with +1 nucleosome (T40N) in MH-binding state | electron microscopy | DH | — | 3 (best 0.85) |
| 8GXS | PIC-Mediator in complex with +1 nucleosome (T40N) in H-binding state | electron microscopy | DH | — | 3 (best 0.85) |
| 8WAK | Structure of transcribing complex 2 (TC2), the initially transcribing complex with Pol II… | electron microscopy | H | — | 2 (best 0.86) |
| 8WAL | Structure of transcribing complex 3 (TC3), the initially transcribing complex with Pol II… | electron microscopy | H | — | 2 (best 0.87) |
| 8WAN | Structure of transcribing complex 4 (TC4), the initially transcribing complex with Pol II… | electron microscopy | H | — | 2 (best 0.87) |
| 8WAO | Structure of transcribing complex 5 (TC5), the initially transcribing complex with Pol II… | electron microscopy | H | — | 2 (best 0.86) |
| 8WAP | Structure of transcribing complex 6 (TC6), the initially transcribing complex with Pol II… | electron microscopy | H | — | 3 (best 0.87) |
| 8WAQ | Structure of transcribing complex 7 (TC7), the initially transcribing complex with Pol II… | electron microscopy | H | — | 3 (best 0.83) |
| 8WAR | Structure of transcribing complex 8 (TC8), the initially transcribing complex with Pol II… | electron microscopy | H | — | 2 (best 0.87) |
| 8WAS | Structure of transcribing complex 9 (TC9), the initially transcribing complex with Pol II… | electron microscopy | H | — | 2 (best 0.87) |
| Q7Z7C8 | AlphaFold monomer V2.0 prediction for transcription initiation factor tfiid subunit 8 (Q7Z7C8) | predicted | A | — | — |
Ligands
- CL · Chloride ion · in 1 record
Experiment against prediction
- 4WV6 chain C against the predicted model Q7Z7C8: TM-score 0.99, RMSD 0.04 Å
- 4WV6 chain C against the predicted model Q7Z7C8: TM-score 0.99, RMSD 0.04 Å
- 4WV4 chain B against the predicted model Q7Z7C8: TM-score 0.88, RMSD 1.90 Å
- 5FUR chain L against the predicted model Q7Z7C8: TM-score 0.86, RMSD 1.40 Å
- 5FUR chain L against the predicted model Q7Z7C8: TM-score 0.86, RMSD 1.40 Å
- 7EGG chain H against the predicted model Q7Z7C8: TM-score 0.78, RMSD 1.75 Å
- 7EGG chain H against the predicted model Q7Z7C8: TM-score 0.78, RMSD 1.75 Å
- 7EGH chain H against the predicted model Q7Z7C8: TM-score 0.75, RMSD 2.06 Å
- 7EGH chain H against the predicted model Q7Z7C8: TM-score 0.75, RMSD 2.06 Å
- 7EGI chain H against the predicted model Q7Z7C8: TM-score 0.48, RMSD 1.67 Å
Elsewhere
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.