MolNFT v1 · #109184 · protein
Heterodimer of TAF8/TAF10
4WV4 · Transcription initiation factor tfiid subunit 10: “Heterodimer of TAF8/TAF10”. X-ray diffraction, 1 ligand (CL), 1 pocket (best druggability 0.28). MolNFT v1 #109184 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 4WV4
- Type
- protein
- Length
- 179 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Transcription initiation factor tfiid subunit 10; Transcription initiation factor tfiid…
- UniProt
- Q12962, Q7Z7C8
- Ligands
- CL
- Pockets
- 1 · best druggability 0.28
Structure
x-ray diffraction · 2 distinct chains · 70% helix, 2% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Transcription initiation factor tfiid subunit 10 | protein | 86 | 66% helix, 2% strand | Q12962 |
| B | Transcription initiation factor tfiid subunit 8 | protein | 93 | 74% helix, 2% strand | Q7Z7C8 |
Ligands and binding sites
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 62 | 0.28 | 0.73 | 13 | empty |
Interfaces
1 interface between chains.
- A–B · 2313 Ų buried · 14 hydrogen bonds · protein-protein
Compared structures
- Q7Z7C8 · AlphaFold monomer V2.0 prediction for transcription initiation factor tfiid subunit 8… · a predicted model of the same protein · chain B against A, TM-score 0.88
- Q12962 · AlphaFold monomer V2.0 prediction for transcription initiation factor tfiid subunit 10… · a predicted model of the same protein · chain A against A, TM-score 0.87
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q12962
- Every structure of UniProt Q7Z7C8
- Elsewhere: RCSB PDB 4WV4 · PDBe 4WV4 · UniProt Q12962 · UniProt Q7Z7C8
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