MolNFT v1 · #157442 · protein

Human tfiid bc core

6MZC · Transcription initiation factor tfiid subunit 2: “Human tfiid bc core”. Electron microscopy, 20 pockets (best druggability 0.87). MolNFT v1 #157442 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 6MZC
Type: protein
Length: 2,839 residues
Chains: 10
Method: electron microscopy
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Transcription initiation factor tfiid subunit 2; Transcription initiation factor tfiid…
UniProt: Q6P1X5, O00268, Q15542, P49848, Q7Z7C8, Q16594, Q12962, Q16514
Pockets: 20 · best druggability 0.87

Structure

electron microscopy · 10 distinct chains · 46% helix, 10% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
B	Transcription initiation factor tfiid subunit 2	protein	968	37% helix, 14% strand	Q6P1X5
E	Transcription initiation factor tfiid subunit 4	protein	102	72% helix, 2% strand	O00268
G	Transcription initiation factor tfiid subunit 5	protein	473	22% helix, 27% strand	Q15542
H	Transcription initiation factor tfiid subunit 6	protein	257	73% helix, 0% strand	P49848
I	Transcription initiation factor tfiid subunit 6	protein	339	69% helix, 1% strand	P49848
K	Transcription initiation factor tfiid subunit 8	protein	202	47% helix, 1% strand	Q7Z7C8
M	Transcription initiation factor tfiid subunit 9	protein	104	64% helix, 2% strand	Q16594
O	Transcription initiation factor tfiid subunit 10	protein	82	65% helix, 1% strand	Q12962
R	Transcription initiation factor tfiid subunit 12	protein	74	68% helix, 3% strand	Q16514
Z	POLY(UNK)	protein	238	29% helix, 1% strand	—

Pockets

20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	755	0.87	0.90	106	empty
2	584	0.81	0.87	57	empty
3	157	0.79	0.94	28	empty
4	1116	0.78	0.80	96	empty
5	104	0.76	0.96	30	empty

Interfaces

28 interfaces between chains.

K–O · 2384 Å² buried · 20 hydrogen bonds · protein-protein
B–K · 2221 Å² buried · 12 hydrogen bonds · protein-protein
H–Z · 1674 Å² buried · 7 hydrogen bonds · protein-protein
I–M · 1600 Å² buried · 6 hydrogen bonds · protein-protein
E–R · 1564 Å² buried · 9 hydrogen bonds · protein-protein

Compared structures

6MZC · Human TFIID BC core · the same entry in another collection · chain Z against Z, TM-score 1.00
Q6P1X5 · AlphaFold monomer V2.0 prediction for transcription initiation factor tfiid subunit 2… · a predicted model of the same protein · chain B against A, TM-score 0.97
P49848 · AlphaFold monomer V2.0 prediction for transcription initiation factor tfiid subunit 6… · a predicted model of the same protein · chain H against A, TM-score 0.95

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q6P1X5
Every structure of UniProt O00268
Every structure of UniProt Q15542
Every structure of UniProt P49848
Every structure of UniProt Q7Z7C8
Every structure of UniProt Q16594
Every structure of UniProt Q12962
Every structure of UniProt Q16514
Elsewhere: RCSB PDB 6MZC · PDBe 6MZC · UniProt Q6P1X5 · UniProt O00268 · UniProt Q15542 · UniProt P49848 · UniProt Q7Z7C8 · UniProt Q16594 · UniProt Q12962 · UniProt Q16514

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