Research workbench
Human tfiid bc core
Analyse Human tfiid bc core in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6MZC
- Type
- protein
- Length
- 2,839 residues
- Chains
- 10
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Transcription initiation factor tfiid subunit 2; Transcription initiation factor tfiid…
- UniProt
- Q6P1X5, O00268, Q15542, P49848, Q7Z7C8, Q16594, Q12962, Q16514
- Pockets
- 20 · best druggability 0.87
Structure
electron microscopy · 10 distinct chains · 46% helix, 10% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| B | Transcription initiation factor tfiid subunit 2 | protein | 968 | 37% helix, 14% strand | Q6P1X5 |
| E | Transcription initiation factor tfiid subunit 4 | protein | 102 | 72% helix, 2% strand | O00268 |
| G | Transcription initiation factor tfiid subunit 5 | protein | 473 | 22% helix, 27% strand | Q15542 |
| H | Transcription initiation factor tfiid subunit 6 | protein | 257 | 73% helix, 0% strand | P49848 |
| I | Transcription initiation factor tfiid subunit 6 | protein | 339 | 69% helix, 1% strand | P49848 |
| K | Transcription initiation factor tfiid subunit 8 | protein | 202 | 47% helix, 1% strand | Q7Z7C8 |
| M | Transcription initiation factor tfiid subunit 9 | protein | 104 | 64% helix, 2% strand | Q16594 |
| O | Transcription initiation factor tfiid subunit 10 | protein | 82 | 65% helix, 1% strand | Q12962 |
| R | Transcription initiation factor tfiid subunit 12 | protein | 74 | 68% helix, 3% strand | Q16514 |
| Z | POLY(UNK) | protein | 238 | 29% helix, 1% strand | — |
Pockets
20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 755 | 0.87 | 0.90 | 106 | empty |
| 2 | 584 | 0.81 | 0.87 | 57 | empty |
| 3 | 157 | 0.79 | 0.94 | 28 | empty |
| 4 | 1116 | 0.78 | 0.80 | 96 | empty |
| 5 | 104 | 0.76 | 0.96 | 30 | empty |
Interfaces
28 interfaces between chains.
- K–O · 2384 Ų buried · 20 hydrogen bonds · protein-protein
- B–K · 2221 Ų buried · 12 hydrogen bonds · protein-protein
- H–Z · 1674 Ų buried · 7 hydrogen bonds · protein-protein
- I–M · 1600 Ų buried · 6 hydrogen bonds · protein-protein
- E–R · 1564 Ų buried · 9 hydrogen bonds · protein-protein
Compared structures
- 6MZC · Human TFIID BC core · the same entry in another collection · chain Z against Z, TM-score 1.00
- Q6P1X5 · AlphaFold monomer V2.0 prediction for transcription initiation factor tfiid subunit 2… · a predicted model of the same protein · chain B against A, TM-score 0.97
- P49848 · AlphaFold monomer V2.0 prediction for transcription initiation factor tfiid subunit 6… · a predicted model of the same protein · chain H against A, TM-score 0.95
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q6P1X5
- Every structure of UniProt O00268
- Every structure of UniProt Q15542
- Every structure of UniProt P49848
- Every structure of UniProt Q7Z7C8
- Every structure of UniProt Q16594
- Every structure of UniProt Q12962
- Every structure of UniProt Q16514
- Elsewhere: RCSB PDB 6MZC · PDBe 6MZC · UniProt Q6P1X5 · UniProt O00268 · UniProt Q15542 · UniProt P49848 · UniProt Q7Z7C8 · UniProt Q16594 · UniProt Q12962 · UniProt Q16514
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