MolNFT v1 · #177372 · protein + DNA
Tfiid lobe C subcomplex
7EGH · Transcription initiation factor tfiid subunit 1: “Tfiid lobe C subcomplex”. Electron microscopy, 20 pockets (best druggability 0.78). MolNFT v1 #177372 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 7EGH
- Type
- protein + DNA
- Length
- 2,426 residues
- Chains
- 8
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Transcription initiation factor tfiid subunit 1; Transcription initiation factor tfiid…
- EC
- 2.3.1.48, 2.7.11.1
- UniProt
- P21675, Q6P1X5, P49848, Q15545, Q7Z7C8
- Pockets
- 20 · best druggability 0.78
Structure
electron microscopy · 8 distinct chains · 45% helix, 14% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Transcription initiation factor tfiid subunit 1 (EC 2.3.1.48, 2.7.11.1) | protein | 630 | 37% helix, 13% strand | P21675 |
| B | Transcription initiation factor tfiid subunit 2 | protein | 963 | 40% helix, 20% strand | Q6P1X5 |
| F | Transcription initiation factor tfiid subunit 6 | protein | 267 | 68% helix, 0% strand | P49848 |
| G | Transcription initiation factor tfiid subunit 7 | protein | 144 | 26% helix, 38% strand | Q15545 |
| H | Transcription initiation factor tfiid subunit 8 | protein | 72 | 43% helix, 6% strand | Q7Z7C8 |
| X | DNA (45-mer) | dna | 45 | — | — |
| Y | DNA (45-mer) | dna | 45 | — | — |
| f | Transcription initiation factor tfiid subunit 6 | protein | 260 | 66% helix, 0% strand | P49848 |
Pockets
20 pockets found on a 1 Å grid, 13 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 827 | 0.78 | 0.81 | 77 | empty |
| 2 | 576 | 0.77 | 0.84 | 60 | empty |
| 3 | 737 | 0.71 | 0.78 | 61 | empty |
| 4 | 725 | 0.70 | 0.77 | 47 | empty |
| 5 | 426 | 0.69 | 0.81 | 39 | empty |
Interfaces
15 interfaces between chains.
- A–G · 5043 Ų buried · 83 hydrogen bonds · protein-protein
- A–f · 2654 Ų buried · 23 hydrogen bonds · protein-protein
- B–H · 2231 Ų buried · 19 hydrogen bonds · protein-protein
- X–Y · 2094 Ų buried · 145 hydrogen bonds · nucleic-nucleic
- A–F · 1692 Ų buried · 13 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 1 disulfide (disulfide).
Compared structures
- 7EGH · TFIID lobe C subcomplex · the same entry in another collection · chain f against f, TM-score 1.00
- Q6P1X5 · AlphaFold monomer V2.0 prediction for transcription initiation factor tfiid subunit 2… · a predicted model of the same protein · chain B against A, TM-score 0.99
- P49848 · AlphaFold monomer V2.0 prediction for transcription initiation factor tfiid subunit 6… · a predicted model of the same protein · chain f against A, TM-score 0.96
- Q15545 · AlphaFold monomer V2.0 prediction for transcription initiation factor tfiid subunit 7… · a predicted model of the same protein · chain G against A, TM-score 0.78
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P21675
- Every structure of UniProt Q6P1X5
- Every structure of UniProt P49848
- Every structure of UniProt Q15545
- Every structure of UniProt Q7Z7C8
- Elsewhere: RCSB PDB 7EGH · PDBe 7EGH · UniProt P21675 · UniProt Q6P1X5 · UniProt P49848 · UniProt Q15545 · UniProt Q7Z7C8
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