UniProt Q9Y253
DNA polymerase eta (Q9Y253)
DNA polymerase eta (UniProt Q9Y253), EC 2.7.7.7: 434 experimental structures on GenesisL1, 27 ligands bound, 736 pockets. Binding sites, pockets, druggability and 3D structures in GL1X.
- UniProt
- Q9Y253
- Protein
- DNA polymerase eta
- EC
- 2.7.7.7
- Experimental structures
- 434
- Predicted models
- 0
- Ligands
- 27
- Pockets
- 736 · 143 records with a druggable one
Structures
434 records of Q9Y253 in the MolNFT archive: 434 experimental, 0 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 2I5O | Solution Structure of the Ubiquitin-Binding Zinc Finger (UBZ) Domain of the Human DNA Y-Polymerase… | solution nmr | A | — | — |
| 2I5O | Solution structure of the ubiquitin-binding zinc finger (ubz) domain of the human DNA Y-polymerase… | solution nmr | A | — | — |
| 2LSK | C-terminal domain of human REV1 in complex with DNA-polymerase H (eta) | solution nmr | B | — | — |
| 2LSK | C-terminal domain of human REV1 in complex with DNA-polymerase H (eta) | solution nmr | B | — | — |
| 3JAA | HUMAN DNA POLYMERASE ETA in COMPLEX WITH NORMAL DNA AND INCO NUCLEOTIDE (NRM) | electron microscopy | A | — | — |
| 3JAA | Human DNA polymerase eta in complex with normal DNA and inco nucleotide (nrm) | electron microscopy | A | — | — |
| 3MR2 | Human DNA polymerase eta in complex with normal DNA and incoming nucleotide (Nrm) | x-ray diffraction | A | — | — |
| 3MR2 | Human DNA polymerase eta in complex with normal DNA and incoming nucleotide (nrm) | x-ray diffraction | A | — | — |
| 3MR3 | Human DNA polymerase eta - DNA ternary complex with the 3'T of a CPD in the active site (TT1) | x-ray diffraction | A | — | — |
| 3MR3 | Human DNA polymerase eta - DNA ternary complex with the 3'T of a cpd in the active site (TT1) | x-ray diffraction | A | — | — |
| 3MR5 | Human DNA polymerase eta - DNA ternary complex with a CPD 1bp upstream of the active site (TT3) | x-ray diffraction | A | — | — |
| 3MR5 | Human DNA polymerase eta - DNA ternary complex with a cpd 1BP upstream of the active site (TT3) | x-ray diffraction | A | — | — |
| 3MR6 | Human DNA polymerase eta - DNA ternary complex with a CPD 2bp upstream of the active site (TT4) | x-ray diffraction | A | — | — |
| 3MR6 | Human DNA polymerase eta - DNA ternary complex with a cpd 2BP upstream of the active site (TT4) | x-ray diffraction | A | — | — |
| 3SI8 | Human DNA polymerase eta - DNA ternary complex with the 5'T of a CPD in the active site (TT2) | x-ray diffraction | A | — | — |
| 3SI8 | Human DNA polymerase eta - DNA ternary complex with the 5'T of a cpd in the active site (TT2) | x-ray diffraction | A | — | — |
| 3TQ1 | Human DNA Polymerase eta in binary complex with DNA | x-ray diffraction | A | — | — |
| 3TQ1 | Human DNA polymerase eta in binary complex with DNA | x-ray diffraction | A | — | — |
| 3WUP | Crystal Structure of the Ubiquitin-Binding Zinc Finger (UBZ) Domain of the Human DNA Polymerase Eta | x-ray diffraction | A | — | — |
| 3WUP | Crystal structure of the ubiquitin-binding zinc finger (ubz) domain of the human DNA polymerase eta | x-ray diffraction | A | — | — |
| 4DL2 | Human DNA polymerase eta inserting dCMPNPP opposite CG template (GG0a) | x-ray diffraction | A | — | — |
| 4DL2 | Human DNA polymerase eta inserting dcmpnpp opposite cg template (GG0A) | x-ray diffraction | A | — | — |
| 4DL3 | Human DNA polymerase eta inserting dCMPNPP opposite GG template (GG0b). | x-ray diffraction | A | — | — |
| 4DL3 | Human DNA polymerase eta inserting dcmpnpp opposite gg template (GG0B). | x-ray diffraction | A | — | — |
| 4DL4 | Human DNA polymerase eta inserting dCMPNPP opposite the 3'G of cisplatin crosslinked Gs (Pt-GG1). | x-ray diffraction | A | — | — |
| 4DL4 | Human DNA polymerase eta inserting dcmpnpp opposite the 3'G of cisplatin crosslinked gs (pt-GG1). | x-ray diffraction | A | — | — |
| 4DL5 | Human DNA polymerase eta inserting dCMPNPP opposite the 5'G of cisplatin crosslinked Gs (Pt-GG2). | x-ray diffraction | A | — | — |
| 4DL5 | Human DNA polymerase eta inserting dcmpnpp opposite the 5'G of cisplatin crosslinked gs (pt-GG2). | x-ray diffraction | A | — | — |
| 4DL6 | Human DNA polymerase eta extending primer immediately after cisplatin crosslink (Pt-GG3). | x-ray diffraction | A | — | — |
| 4DL6 | Human DNA polymerase eta extending primer immediately after cisplatin crosslink (pt-GG3). | x-ray diffraction | A | — | — |
| 4DL7 | Human DNA polymerase eta fails to extend primer 2 nucleotide after cisplatin crosslink (Pt-GG4). | x-ray diffraction | A | — | — |
| 4DL7 | Human DNA polymerase eta fails to extend primer 2 nucleotide after cisplatin crosslink (pt-GG4). | x-ray diffraction | A | — | — |
| 4ECQ | Human DNA polymerase eta- DNA ternary complex: AT crystal at pH6.8(K+ MES) with 1 Ca2+ ion | x-ray diffraction | A | — | — |
| 4ECQ | Human DNA polymerase eta- DNA ternary complex: at crystal at PH6.8(K+ mes) with 1 CA2+ ion | x-ray diffraction | A | — | — |
| 4ECR | Human DNA polymerase eta - DNA ternary complex: Reaction in the AT crystal at pH 7.0 for 40 sec | x-ray diffraction | A | — | — |
| 4ECR | Human DNA polymerase eta - DNA ternary complex: reaction in the at crystal at pH 7.0 for 40 sec | x-ray diffraction | A | — | — |
| 4ECS | Human DNA polymerase eta - DNA ternary complex: Reaction in the AT crystal at pH 7.0 for 80 sec | x-ray diffraction | A | — | — |
| 4ECS | Human DNA polymerase eta - DNA ternary complex: reaction in the at crystal at pH 7.0 for 80 sec | x-ray diffraction | A | — | — |
| 4ECT | Human DNA polymerase eta - DNA ternary complex: Reaction in the AT crystal at pH 7.0 for 140 sec | x-ray diffraction | A | — | — |
| 4ECT | Human DNA polymerase eta - DNA ternary complex: reaction in the at crystal at pH 7.0 for 140 sec | x-ray diffraction | A | — | — |
| 4ECU | Human DNA polymerase eta - DNA ternary complex: Reaction in the AT crystal at pH 7.0 for 200 sec | x-ray diffraction | A | — | — |
| 4ECU | Human DNA polymerase eta - DNA ternary complex: reaction in the at crystal at pH 7.0 for 200 sec | x-ray diffraction | A | — | — |
| 4ECV | Human DNA polymerase eta - DNA ternary complex: Reaction in the AT crystal at pH 7.0 for 230 sec | x-ray diffraction | A | — | — |
| 4ECV | Human DNA polymerase eta - DNA ternary complex: reaction in the at crystal at pH 7.0 for 230 sec | x-ray diffraction | A | — | — |
| 4ECW | Human DNA polymerase eta - DNA ternary complex: Reaction in the AT crystal at pH 7.0 for 250 sec | x-ray diffraction | A | — | — |
| 4ECW | Human DNA polymerase eta - DNA ternary complex: reaction in the at crystal at pH 7.0 for 250 sec | x-ray diffraction | A | — | — |
| 4ECX | Human DNA polymerase eta - DNA ternary complex: Reaction in the AT crystal at pH 7.0 for 300 sec | x-ray diffraction | A | — | — |
| 4ECX | Human DNA polymerase eta - DNA ternary complex: reaction in the at crystal at pH 7.0 for 300 sec | x-ray diffraction | A | — | — |
| 4ECY | Human DNA polymerase eta - DNA ternary complex: AT crystal at pH 6.0 (Na+ MES) with 1 Ca2+ ion | x-ray diffraction | A | — | — |
| 4ECY | Human DNA polymerase eta - DNA ternary complex: at crystal at pH 6.0 (na+ mes) with 1 CA2+ ion | x-ray diffraction | A | — | — |
| 4ECZ | Human DNA polymerase eta - DNA ternary complex: AT crystal at pH 6.5 (Na+ MES) with 1 Ca2+ ion | x-ray diffraction | A | — | — |
| 4ECZ | Human DNA polymerase eta - DNA ternary complex: at crystal at pH 6.5 (na+ mes) with 1 CA2+ ion | x-ray diffraction | A | — | — |
| 4ED0 | Human DNA polymerase eta - DNA ternary complex: AT crystal at pH 6.8 (Na+ MES) with 1 Ca2+ ion | x-ray diffraction | A | — | — |
| 4ED0 | Human DNA polymerase eta - DNA ternary complex: at crystal at pH 6.8 (na+ mes) with 1 CA2+ ion | x-ray diffraction | A | — | — |
| 4ED1 | Human DNA polymerase eta - DNA ternary complex: AT crystal at pH 7.0 (Na+ MES) with 1 Ca2+ ion | x-ray diffraction | A | — | — |
| 4ED1 | Human DNA polymerase eta - DNA ternary complex: at crystal at pH 7.0 (na+ mes) with 1 CA2+ ion | x-ray diffraction | A | — | — |
| 4ED2 | Human DNA polymerase eta - DNA ternary complex: AT crystal at pH 7.2 (Na+ HEPES) with 1 Ca2+ ion | x-ray diffraction | A | — | — |
| 4ED2 | Human DNA polymerase eta - DNA ternary complex: at crystal at pH 7.2 (na+ hepes) with 1 CA2+ ion | x-ray diffraction | A | — | — |
| 4ED3 | Human DNA polymerase eta - DNA ternary complex: AT crystal at pH 7.5 (Na+ HEPES) with 1 Ca2+ ion | x-ray diffraction | A | — | — |
| 4ED3 | Human DNA polymerase eta - DNA ternary complex: at crystal at pH 7.5 (na+ hepes) with 1 CA2+ ion | x-ray diffraction | A | — | — |
374 records more on the page itself.
Ligands
- MG · Magnesium ion · in 137 records
- CA · Calcium ion · in 116 records
- MN · Manganese (II) ion · in 106 records
- DTP · 2'-deoxyadenosine 5'-triphosphate · in 98 records
- DPO · Diphosphate · in 87 records
- XG4 · 2'-deoxy-5'-O-[(R)-hydroxy{[(R)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]guanosine · in 44 records
- DGT · 2'-deoxyguanosine-5'-triphosphate · in 43 records
- DZ4 · 2'-deoxy-5'-O-[(R)-hydroxy{[(r)-hydroxy(phosphonooxy) phosphoryl]amino}phosphoryl]adenosine · in 31 records
- K · Potassium ion · in 30 records
- 0KX · 2'-deoxy-5'-O-[(R)-hydroxy{[(r)-hydroxy(phosphonooxy) phosphoryl]amino}phosphoryl]cytidine · in 20 records
- 1FZ · 5'-O-[(R)-hydroxy{[(R)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]thymidine · in 12 records
- STP · 2'-deoxyadenosine 5'-O-(1-thiotriphosphate) · in 12 records
- DCP · 2'-deoxycytidine-5'-triphosphate · in 7 records
- NI · Nickel (II) ion · in 6 records
- NA · Sodium ion · in 4 records
- B7P · 2'-deoxy-5-fluorouridine 5'-(tetrahydrogen triphosphate) · in 3 records
- CZU · [[(2~{R},3~{S},4~{R},5~{R})-3,4-bis(oxidanyl)-5-(6-oxidanylidene-1~{H}-purin-9-yl)oxolan-2-yl]methoxy-oxidanyl-phosphoryl] phosphono hydrogen phosphate · in 3 records
- TTP · Thymidine-5'-triphosphate · in 3 records
- CL · Chloride ion · in 2 records
- CTP · Cytidine-5'-triphosphate · in 2 records
- Y43 · 2'-deoxyinosine 5'-triphosphate · in 2 records
- A1ANT · [(3~{S},4~{R},5~{R})-5-[5-methyl-2,4-bis(oxidanylidene)pyrimidin-1-yl]-4-oxidanyl-oxolan-3-yl] [oxidanyl(phosphonooxy)phosphoryl] hydrogen phosphate · in 1 record
- ATP · Adenosine-5'-triphosphate · in 1 record
- GTF · 2'-deoxy-2',2'-difluorocytidine 5'-(tetrahydrogen triphosphate) · in 1 record
- HF4 · 4-amino-1-{5-O-[(S)-hydroxy{[(r)-hydroxy(phosphonooxy) phosphoryl]oxy}phosphoryl]-beta-D-arabinofuranosyl}pyrimidin-2(1H)-one · in 1 record
- QRV · 2-amino-9-(2-deoxy-2-fluoro-5-O-phosphono-beta-D-arabinofuranosyl)-7-{2-[(2-hydroxyethyl)(phenyl) amino]ethyl}-6-oxo-6,9-dihydro-1H-purin-7-ium · in 1 record
- T0P · [(2~{R},3~{R},4~{S},5~{R})-5-(2-azanyl-6-oxidanylidene-7-phenacyl-1~{H}-purin-9-yl)-4-fluoranyl-3-oxidanyl-oxolan-2-yl]methyl dihydrogen phosphate · in 1 record
Elsewhere
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