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Ligand · 1FZ

1FZ · 5'-O-[(R)-hydroxy{[(R)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]thymidine

1FZ, 5'-O-[(R)-hydroxy{[(R)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]thymidine (C10 H18 N3 O13 P3, 481.2 g/mol), in the MolNFT structures on GenesisL1: bound in 14 records (11 PDB entries). Every binding site with its residues…

Component
1FZ
Formula
C10 H18 N3 O13 P3
Class
ligand
Structures
14
PDB entries
11

Binding sites

1FZ in 14 structures; the first of them:

  • 5DGA · CRYSTAL STRUCTURE OF HUMAN DNA POLYMERASE ETA EXTENDING AN 1,N6-ETHENODEOXYADENOSINE : dT… · 1FZ A501 · binds ASP13, MET14, ASP15, CYS16, PHE17, PHE18, ILE48, ALA49 and 9 more
  • 5L1J · Crystal Structure of Human DNA Polymerase Eta Inserting dTMPNPP Opposite… · 1FZ A504 · binds ASP13, MET14, ASP15, CYS16, PHE17, PHE18, ILE48, ALA49 and 8 more
  • 6M7O · Human DNA polymerase eta ternary complex with Mn2+ and dTMPNPP oppositing cdA · 1FZ A503 · binds ASP13, MET14, ASP15, CYS16, PHE17, PHE18, ILE48, ALA49 and 7 more
  • 6VGM · Crystal structure of DPO4 with 8-oxoadenine (oxoA) and dTTP* · 1FZ A401 · binds ASP7, PHE8, ASP9, TYR10, PHE11, TYR12, ALA44, THR45 and 10 more
  • 5L1J · Crystal structure of human DNA polymerase eta inserting dtmpnpp opposite… · 1FZ A504 · binds ASP13, MET14, ASP15, CYS16, PHE17, PHE18, ILE48, ALA49 and 8 more
  • 6E3V · Structure of human DNA polymerase beta complexed with 8OA in the template base paired… · 1FZ A404 · binds ARG149, GLY179, SER180, ARG183, SER188, GLY189, ASP190, ASP192 and 9 more
  • 6M7O · Human DNA polymerase eta ternary complex with MN2+ and dtmpnpp oppositing cda · 1FZ A503 · binds ASP13, MET14, ASP15, CYS16, PHE17, PHE18, ILE48, ALA49 and 7 more
  • 6M7U · Human DNA polymerase eta in a non-productive ternary complex with MG2+ and dtmpnpp… · 1FZ A502 · binds ASP13, MET14, ASP15, CYS16, PHE17, PHE18, ILE48, ALA49 and 8 more
  • 6PL7 · Structure of human DNA polymerase eta complexed with a in the template base paired with… · 1FZ A501 · binds ASP13, MET14, ASP15, CYS16, PHE17, PHE18, ILE48, ALA49 and 8 more
  • 6PL8 · Structure of human DNA polymerase eta complexed with 8OA in the template base paired with… · 1FZ A501 · binds ASP13, MET14, ASP15, CYS16, PHE17, PHE18, ILE48, ALA49 and 9 more
  • 6TXE · Crystal structure of tetrameric human wt-SAMHD1 (residues 109-626) with GTP, datp… · 1FZ A704 · binds GLN149, LEU150, ARG164, HIS167, ASP207, HIS210, HIS215, HIS233 and 7 more
  • 6VGM · Crystal structure of DPO4 with 8-oxoadenine (oxoa) and dttp* · 1FZ A401 · binds ASP7, PHE8, ASP9, TYR10, PHE11, TYR12, ALA44, THR45 and 8 more
  • 7MZ1 · Structure of human DNA polymerase beta complexed with dza in the template base paired… · 1FZ A404 · binds 4DU6, DA10, GLY179, SER180, ARG183, SER188, GLY189, ASP190 and 8 more
  • 7MZ4 · Structure of human DNA polymerase beta complexed with 3-deaza-3- methyladenine (3DMEA) in… · 1FZ A404 · binds ARG149, GLY179, SER180, ARG183, SER188, GLY189, ASP190, ASP192 and 9 more

Residues it binds most

ASP 31, HIS 16, ARG 31, TYR 31, GLN 16, LYS 28, PHE 15, ALA 12, LEU 16, ILE 12 (residue and the binding sites it lines).

Found with

  • MG · Magnesium ion
  • GOL · Glycerol
  • NA · Sodium ion
  • MN · Manganese (II) ion
  • DTP · 2'-deoxyadenosine 5'-triphosphate
  • GTP · Guanosine-5'-triphosphate
  • FE · Fe (III) ion
  • NI · Nickel (II) ion
  • CL · Chloride ion
  • SO4 · Sulfate ion

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