CZU · [[(2~{R},3~{S},4~{R},5~{R})-3,4-bis(oxidanyl)-5-(6-oxidanylidene-1~{H}-purin-9-yl)oxolan-2-yl]methoxy-oxidanyl-phosphoryl] phosphono hydrogen phosphate

Binding sites

CZU in 7 structures; the first of them:

• 7EM4 · Crystal structure of the PI5P4Kbeta F205L-ITP complex · CZU A502 · binds PHE71, LYS72, LYS76, LYS96, TYR98, SER154, VAL157, ALA158 and 5 more
• 7EM6 · Crystal structure of the PI5P4Kbeta N203D-ITP complex · CZU A502 · binds PHE71, LYS72, LYS76, LYS96, TYR98, SER154, VAL157, ALA158 and 5 more
• 8G8H · Crystal structure of human DNA polymerase eta incorporating ITP across dC · CZU A501 · binds ASP13, MET14, ASP15, CYS16, PHE17, PHE18, ILE48, ALA49 and 11 more
• 8G8J · Crystal structure of human DNA polymerase eta incorporating ITP across dT · CZU A501 · binds ASP13, MET14, ASP15, CYS16, PHE17, PHE18, ILE48, ALA49 and 10 more
• 7EM1 · Crystal structure of the PI5P4KBETA-itp complex · CZU A502 · binds LYS72, LYS96, TYR98, SER154, VAL157, ALA158, HIS161, ARG188 and 2 more
• 7EM4 · Crystal structure of the PI5P4KBETA F205L-itp complex · CZU A502 · binds LYS72, LYS76, LYS96, TYR98, SER154, ALA158, HIS161, ASN162 and 3 more
• 7EM6 · Crystal structure of the PI5P4KBETA N203D-itp complex · CZU A502 · binds LYS72, LYS96, TYR98, SER154, VAL157, ALA158, HIS161, ARG188 and 2 more

Residues it binds most

LYS 6, TYR 7, ARG 7, ALA 7, GLU 7, ASP 2, PHE 4, HIS 5, SER 5, ILE 2 (residue and the binding sites it lines).

Found with

• IDP · Inosine-5'-diphosphate
• CA · Calcium ion