UniProt Q9XSM3
Transient receptor potential cation channel subfamily V member 5 (Q9XSM3)
Transient receptor potential cation channel subfamily V member 5 (UniProt Q9XSM3): 44 experimental structures on GenesisL1, 11 ligands bound, 440 pockets. Binding sites, pockets, druggability and 3D structures in GL1X.
- UniProt
- Q9XSM3
- Protein
- Transient receptor potential cation channel subfamily V member 5
- Experimental structures
- 44
- Predicted models
- 0
- Ligands
- 11
- Pockets
- 440 · 22 records with a druggable one
Structures
44 records of Q9XSM3 in the MolNFT archive: 44 experimental, 0 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 6B5V | Structure of TRPV5 in complex with econazole | electron microscopy | A, B, D, C | ECL, CA | 20 (best 0.86) |
| 6B5V | Structure of TRPV5 in complex with econazole | electron microscopy | A, B, D, C | ECL, CA | — |
| 6DMR | Lipid-bound full-length rbTRPV5 | electron microscopy | A, B, C, D | — | 20 (best 0.88) |
| 6DMR | Lipid-bound full-length RBTRPV5 | electron microscopy | A, B, C, D | — | — |
| 6DMU | PI(4,5)P2 bound full-length rbTRPV5 | electron microscopy | A, B, C, D | PIO | 20 (best 0.83) |
| 6DMU | PI(4,5)P2 bound full-length RBTRPV5 | electron microscopy | A, B, C, D | PIO | — |
| 6DMW | Calmodulin-bound full-length rbTRPV5 | electron microscopy | A, B, C, D | — | — |
| 6DMW | Calmodulin-bound full-length RBTRPV5 | electron microscopy | A, B, C, D | — | — |
| 6O1N | Cryo-EM structure of TRPV5 (1-660) in nanodisc | electron microscopy | A, B, C, D | — | — |
| 6O1N | Cryo-EM structure of TRPV5 (1-660) in nanodisc | electron microscopy | A, B, C, D | — | — |
| 6O1P | Cryo-EM structure of full length TRPV5 in nanodisc | electron microscopy | A, B, C, D | — | 20 (best 0.84) |
| 6O1P | Cryo-EM structure of full length TRPV5 in nanodisc | electron microscopy | A, B, C, D | — | — |
| 6O1U | Cryo-EM structure of TRPV5 W583A in nanodisc | electron microscopy | A, B, C, D | — | 20 (best 0.85) |
| 6O1U | Cryo-EM structure of TRPV5 W583A in nanodisc | electron microscopy | A, B, C, D | — | — |
| 6O20 | Cryo-EM structure of TRPV5 with calmodulin bound | electron microscopy | A, E, B, C, D | — | 20 (best 0.82) |
| 6O20 | Cryo-EM structure of TRPV5 with calmodulin bound | electron microscopy | A, E, B, C, D | — | — |
| 6PBE | ZINC17988990-bound TRPV5 in nanodiscs | electron microscopy | A, B, C, D | O6S | 20 (best 0.87) |
| 6PBE | ZINC17988990-bound TRPV5 in nanodiscs | electron microscopy | A, B, C, D | O6S | — |
| 6PBF | ZINC9155420-bound TRPV5 in nanodiscs | electron microscopy | A, B, C, D | O6V | 20 (best 0.84) |
| 6PBF | ZINC9155420-bound TRPV5 in nanodiscs | electron microscopy | A, B, C, D | O6V | — |
| 7T6J | Cryo-EM structure of TRPV5 at pH8 in nanodiscs | electron microscopy | A, B, C, D | — | 20 (best 0.84) |
| 7T6J | Cryo-EM structure of TRPV5 at PH8 in nanodiscs | electron microscopy | A, B, C, D | — | — |
| 7T6K | Cryo-EM structure of TRPV5 at pH6 in nanodiscs | electron microscopy | A, B, C, D | — | 20 (best 0.84) |
| 7T6K | Cryo-EM structure of TRPV5 at PH6 in nanodiscs | electron microscopy | A, B, C, D | — | — |
| 7T6L | Cryo-EM structure of TRPV5 at PH5 in nanodiscs | electron microscopy | A, B, C, D | — | — |
| 7T6M | Cryo-EM structure of TRPV5 in nanodiscs with PI(4,5)P2 at pH6 state 1 | electron microscopy | A, B, C, D | PIO | 20 (best 0.82) |
| 7T6M | Cryo-EM structure of TRPV5 in nanodiscs with PI(4,5)P2 at PH6 state 1 | electron microscopy | A, B, C, D | PIO | — |
| 7T6N | Cryo-EM structure of TRPV5 in nanodiscs at pH6 state 2 | electron microscopy | A, B, C, D | — | 20 (best 0.84) |
| 7T6N | Cryo-EM structure of TRPV5 in nanodiscs at PH6 state 2 | electron microscopy | A, B, C, D | — | — |
| 7T6O | Cryo-EM structure of TRPV5 in nanodiscs at pH6 state 3 | electron microscopy | A, B, C, D | — | 20 (best 0.89) |
| 7T6O | Cryo-EM structure of TRPV5 in nanodiscs at PH6 state 3 | electron microscopy | A, B, C, D | — | — |
| 7T6P | Cryo-EM structure of TRPV5 T709D in nanodiscs | electron microscopy | A, B, C, D | — | — |
| 7T6Q | Cryo-EM structure of TRPV5 T709D with PI(4,5)P2 in nanodiscs | electron microscopy | A, B, C, D | PIO | 20 (best 0.84) |
| 7T6Q | Cryo-EM structure of TRPV5 T709D with PI(4,5)P2 in nanodiscs | electron microscopy | A, B, C, D | PIO | — |
| 7T6R | Cryo-EM structure of TRPV5 T709D in nanodiscs in the presence of Calmodulin | electron microscopy | A, B, C, D | — | 20 (best 0.83) |
| 7T6R | Cryo-EM structure of TRPV5 T709D in nanodiscs in the presence of calmodulin | electron microscopy | A, B, C, D | — | — |
| 8FFN | RR-bound wildtype rabbit TRPV5 in nanodiscs | electron microscopy | A, B, C, D | R2R, POV, ERG | 20 (best 0.86) |
| 8FFO | Cryo-EM structure of wildtype rabbit TRPV5 with PI(4,5)P2 in nanodiscs | electron microscopy | A, B, C, D | ERG, CPL, PIO | 20 (best 0.85) |
| 8FFQ | Wildtype rabbit TRPV5 into nanodiscs in the presence of PI(4,5)P2 and ruthenium red | electron microscopy | A, B, C, D | ERG, R2R, CPL | 20 (best 0.85) |
| 8FHH | Wildtype rabbit TRPV5 in nanodiscs in the presence of oleoyl coenzyme A, Closed stated | electron microscopy | A, B, C, D | POV, ERG | 20 (best 0.85) |
| 8FHI | Wildtype rabbit TRPV5 in nanodiscs in complex with oleoyl coenzyme A, Open stated | electron microscopy | A, B, C, D | ERG, 3VV, POV | 20 (best 0.84) |
| 8TF3 | Wildtype rabbit TRPV5 into nanodiscs in complex with econazole | electron microscopy | A, B, C, D | ERG, CPL, ECN | 20 (best 0.86) |
| 8TF4 | Wildtype rabbit TRPV5 into nanodiscs in the presence of PI(4,5)P2 and econazole | electron microscopy | A, B, C, D | ERG, CPL, ECN | 20 (best 0.85) |
| Q9XSM3 | AlphaFold monomer V2.0 prediction for transient receptor potential cation channel subfamily V… | — | — | — |
Ligands
- ERG · Ergosterol · in 7 records
- PIO · [(2R)-2-octanoyloxy-3-[oxidanyl-[(1R,2R,3S,4R,5R,6S)-2, 3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate · in 7 records
- CPL · 1-palmitoyl-2-linoleoyl-sn-glycero-3-phosphocholine · in 4 records
- POV · (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate · in 3 records
- CA · Calcium ion · in 2 records
- ECL · 1-[(2R)-2-[(4-chlorobenzyl)oxy]-2-(2,4-dichlorophenyl) ethyl]-1H-imidazole · in 2 records
- ECN · 1-[(2S)-2-[(4-chlorobenzyl)oxy]-2-(2,4-dichlorophenyl)ethyl]-1H-imidazole · in 2 records
- O6S · (4-oxo-5-phenyl-3,4-dihydrothieno[2,3-d]pyrimidin-2-yl)methyl 3-(3-oxo-2,3-dihydro-4H-1,4-benzoxazin-4-yl)propanoate · in 2 records
- O6V · (1S)-1-(4-oxo-5-phenyl-3,4-dihydrothieno[2,3-d]pyrimidin-2-yl)ethyl [(2S)-3-oxo-3,4-dihydro-2H-1,4-benzothiazin-2-yl]acetate · in 2 records
- R2R · ruthenium(6+) azanide pentaamino(oxido)ruthenium (1/4/2) · in 2 records
- 3VV · S-{(3R,5R,9R)-1-[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-4-hydroxy-3-(phosphonooxy)tetrahydrofuran-2-yl]-3, 5,9-trihydroxy-8,8-dimethyl-3,5-dioxido-10,14-dioxo-2, 4,6-trioxa-11,15-diaza-3lambda~5~,5lambda~5~-diphosphaheptadecan-17-yl} (9Z)-octadec-9-enethioate (non-preferred name) · in 1 record
Elsewhere
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