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Ligand · ECL

ECL · 1-[(2R)-2-[(4-chlorobenzyl)oxy]-2-(2,4-dichlorophenyl) ethyl]-1H-imidazole

ECL, 1-[(2R)-2-[(4-chlorobenzyl)oxy]-2-(2,4-dichlorophenyl) ethyl]-1H-imidazole (C18 H15 Cl3 N2 O, 381.7 g/mol), in the MolNFT structures on GenesisL1: bound in 3 records (2 PDB entries). Every binding site with its residues within 4.5 Å…

Component
ECL
Formula
C18 H15 Cl3 N2 O
Class
ligand
Structures
3
PDB entries
2

Binding sites

ECL in 3 structures; the first of them:

  • 6B5V · Structure of TRPV5 in complex with econazole · ECL A1001 · binds PHE425, ILE428, PHE456, LEU460, CYS463, ILE482, GLN483, ALA561 and 1 more
  • 6B5V · Structure of TRPV5 in complex with econazole · ECL A1001 · binds PHE425, PHE456, LEU460, CYS463, ILE482, ALA561
  • 7S8C · Cryo-EM structure of human TRPV6 in complex with inhibitor econazole · ECL A701 · binds VAL465, MET466, PHE468, ALA469, PHE472, MET474, LEU475, TRP495 and 2 more

Residues it binds most

PHE 12, LEU 12, ILE 8, ALA 12, CYS 8, MET 4, VAL 4, GLN 4, TRP 4 (residue and the binding sites it lines).

Found with

  • CA · Calcium ion
  • POV · (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate
  • Y01 · Cholesterol hemisuccinate
  • CL · Chloride ion

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