MolNFT v1 · #158695 · protein

Cryo-EM structure of full length TRPV5 in nanodisc

6O1P · Transient receptor potential cation channel subfamily V…: “Cryo-EM structure of full length TRPV5 in nanodisc”. Electron microscopy, 20 pockets (best druggability 0.84). MolNFT v1 #158695 on GenesisL1: 3D structure, binding sites…

PDB: 6O1P
Type: protein
Length: 2,448 residues
Chains: 4
Method: electron microscopy
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Transient receptor potential cation channel subfamily V member 5
UniProt: Q9XSM3
Pockets: 20 · best druggability 0.84

Structure

electron microscopy · 1 distinct chain · 52% helix, 3% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B, C, D	Transient receptor potential cation channel subfamily V member 5	protein	612	52% helix, 3% strand	Q9XSM3

Pockets

20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	292	0.84	0.95	32	empty
2	151	0.80	0.96	28	empty
3	143	0.80	0.96	27	empty
4	128	0.78	0.96	28	empty
5	110	0.77	0.96	21	empty

Interfaces

6 interfaces between chains.

C–D · 3548 Å² buried · 22 hydrogen bonds · protein-protein
A–D · 3470 Å² buried · 19 hydrogen bonds · protein-protein
B–C · 3417 Å² buried · 16 hydrogen bonds · protein-protein
A–B · 3371 Å² buried · 10 hydrogen bonds · protein-protein
A–C · 40 Å² buried · 0 hydrogen bonds · protein-protein

Compared structures

6O1P · Cryo-EM structure of full length TRPV5 in nanodisc · the same entry in another collection · chain A against A, TM-score 1.00
Q9XSM3 · AlphaFold monomer V2.0 prediction for transient receptor potential cation channel… · a predicted model of the same protein · chain A against A, TM-score 0.98

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q9XSM3
Elsewhere: RCSB PDB 6O1P · PDBe 6O1P · UniProt Q9XSM3

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