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Ligand · ERG

ERG · Ergosterol

ERG, Ergosterol (C28 H44 O, 396.7 g/mol), in the MolNFT structures on GenesisL1: bound in 32 records (25 PDB entries). Every binding site with its residues within 4.5 Å, the residues it binds most and the ligands found with it.

Component
ERG
Formula
C28 H44 O
Class
ligand
Structures
32
PDB entries
25

Binding sites

ERG in 32 structures; the first of them:

  • 5H2D · Crystal structure of Osh1 ORD domain in complex with ergosterol · ERG A1301 · binds LEU847, LEU851, MET859, LEU864, PHE868, LEU874, ARG877, VAL878 and 16 more
  • 5YS0 · Crystal structure of the second StARkin domain of Lam2 in complex with ergosterol · ERG A1301 · binds TYR1115, LYS1117, LEU1119, ASN1121, GLY1124, GLN1149, VAL1151, VAL1156 and 5 more
  • 6CAY · Crystal structure of the first StART-like domain of Ysp2p/Lam2p in its apo and… · ERG A1101 · binds TYR908, LYS910, LEU912, GLY917, PRO918, THR921, CYS923, THR944 and 14 more
  • 6R4L · Crystal structure of S. cerevisia Niemann-Pick type C protein NCR1 · ERG A1201 · binds PHE391, TYR392, THR394, GLN396, GLU450, GLN486, LEU492, LEU510 and 9 more
  • 6R4N · Crystal structure of S. cerevisia Niemann-Pick type C protein NPC2 with ergosterol bound · ERG A302 · binds PRO67, LEU73, VAL95, LEU102, VAL142, TYR147, VAL149, VAL168
  • 7A4P · Structure of small high-light grown Chlorella ohadii photosystem I · ERG G5002 · binds TYR1312, ILE1313, THR1316, SER1317, LEU1319, ARG1323, VAL107, LEU123 and 1 more
  • 7BLZ · Red alga C.merolae Photosystem I · ERG 1618 · binds PRO27, LEU28, ARG29, ASP32, PHE118, LEU122, PRO123, ILE126 and 3 more
  • 7PIW · Stacked stretched Dunaliella PSII · ERG R1626 · binds SER179, LEU180, PRO181, PHE182, LEU2, ILE6, ILE80
  • 7R3K · Chlamydomonas reinhardtii TSP9 mutant small Photosystem I complex · ERG 8325 · binds VAL207, GLN208, GLN211, ARG212, VAL64, ARG67, TRP68, TRP138 and 2 more
  • 7R89 · The structure of human ABCG5/ABCG8 purified from yeast · ERG B901 · binds ASN526, ILE529, SER532, ILE419, GLU423, LEU465
  • 7VPR · Crystal structure of the ligand-binding domain of C. glabrata Upc2 in complex with… · ERG A1001 · binds ILE727, LEU731, VAL746, VAL750, PHE833, PRO836, MET855, MET858 and 12 more
  • 8FFN · RR-bound wildtype rabbit TRPV5 in nanodiscs · ERG A804 · binds PRO424, PHE425, ILE428, PHE456, VAL459, LEU460, CYS463, MET466 and 10 more
  • 8FFO · Cryo-EM structure of wildtype rabbit TRPV5 with PI(4,5)P2 in nanodiscs · ERG A801 · binds PRO424, PHE425, ILE428, SER455, PHE456, VAL459, LEU460, CYS463 and 12 more

Residues it binds most

ILE 92, PHE 97, LEU 104, PRO 97, MET 69, VAL 62, THR 69, ALA 65, CYS 60, GLY 32 (residue and the binding sites it lines).

Found with

  • 3PH · 1,2-diacyl-glycerol-3-sn-phosphate
  • BCR · Beta-carotene
  • C7Z · (1~{S})-3,5,5-trimethyl-4-[(1~{E},3~{E},5~{E},7~{E}, 9~{E},11~{E},13~{E},15~{E},17~{E})-3,7,12,16-tetramethyl-18-[(4~{S})-2,6,6-trimethyl-4-oxidanyl-cyclohexen-1-yl]octadeca-1,3,5,7,9,11,13,15,17-nonaenyl]cyclohex-3-en-1-ol
  • CLA · Chlorophyll A
  • DGA · Diacyl glycerol
  • DGD · Digalactosyl diacyl glycerol (dgdg)
  • LHG · 1,2-dipalmitoyl-phosphatidyl-glycerole
  • PTY · Phosphatidylethanolamine
  • RRX · (3R)-beta,beta-caroten-3-ol
  • NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose
  • CHL · Chlorophyll B
  • CL0 · Chlorophyll A isomer

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