MolNFT v1 · #187991 · protein

Cryo-EM structure of TRPV5 at PH5 in nanodiscs

7T6L · Transient receptor potential cation channel subfamily V…: “Cryo-EM structure of TRPV5 at PH5 in nanodiscs”. Electron microscopy, 20 pockets (best druggability 0.85). MolNFT v1 #187991 on GenesisL1: 3D structure, binding sites and…

PDB: 7T6L
Type: protein
Length: 2,424 residues
Chains: 4
Method: electron microscopy
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Transient receptor potential cation channel subfamily V member 5
UniProt: Q9XSM3
Pockets: 20 · best druggability 0.85

Structure

electron microscopy · 1 distinct chain · 57% helix, 4% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B, C, D	Transient receptor potential cation channel subfamily V member 5	protein	606	57% helix, 4% strand	Q9XSM3

Pockets

20 pockets found on a 1 Å grid, 17 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	495	0.85	0.92	40	empty
2	262	0.80	0.92	20	empty
3	328	0.78	0.88	43	empty
4	326	0.77	0.87	42	empty
5	319	0.76	0.87	42	empty

Interfaces

6 interfaces between chains.

C–D · 3453 Å² buried · 30 hydrogen bonds · protein-protein
A–C · 3452 Å² buried · 33 hydrogen bonds · protein-protein
A–B · 3443 Å² buried · 33 hydrogen bonds · protein-protein
B–D · 3436 Å² buried · 34 hydrogen bonds · protein-protein
B–C · 50 Å² buried · 0 hydrogen bonds · protein-protein

Compared structures

7T6L · Cryo-EM structure of TRPV5 at pH5 in nanodiscs · the same entry in another collection · chain A against A, TM-score 1.00
Q9XSM3 · AlphaFold monomer V2.0 prediction for transient receptor potential cation channel… · a predicted model of the same protein · chain A against A, TM-score 0.98

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q9XSM3
Elsewhere: RCSB PDB 7T6L · PDBe 7T6L · UniProt Q9XSM3

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