MolNFT v1 · #187993 · protein
Cryo-EM structure of TRPV5 in nanodiscs at PH6 state 2
7T6N · Transient receptor potential cation channel subfamily V…: “Cryo-EM structure of TRPV5 in nanodiscs at PH6 state 2”. Electron microscopy, 20 pockets (best druggability 0.84). MolNFT v1 #187993 on GenesisL1: 3D structure, binding…
- PDB
- 7T6N
- Type
- protein
- Length
- 2,424 residues
- Chains
- 4
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Transient receptor potential cation channel subfamily V member 5
- UniProt
- Q9XSM3
- Pockets
- 20 · best druggability 0.84
Structure
electron microscopy · 1 distinct chain · 60% helix, 5% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, C, D | Transient receptor potential cation channel subfamily V member 5 | protein | 606 | 60% helix, 5% strand | Q9XSM3 |
Pockets
20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 303 | 0.84 | 0.94 | 38 | empty |
| 2 | 129 | 0.80 | 0.97 | 26 | empty |
| 3 | 131 | 0.79 | 0.96 | 26 | empty |
| 4 | 131 | 0.78 | 0.96 | 26 | empty |
| 5 | 238 | 0.75 | 0.89 | 24 | empty |
Interfaces
6 interfaces between chains.
- A–B · 3417 Ų buried · 25 hydrogen bonds · protein-protein
- B–D · 3409 Ų buried · 26 hydrogen bonds · protein-protein
- A–C · 3403 Ų buried · 25 hydrogen bonds · protein-protein
- C–D · 3402 Ų buried · 24 hydrogen bonds · protein-protein
- B–C · 42 Ų buried · 0 hydrogen bonds · protein-protein
Compared structures
- 7T6N · Cryo-EM structure of TRPV5 in nanodiscs at pH6 state 2 · the same entry in another collection · chain B against B, TM-score 1.00
- Q9XSM3 · AlphaFold monomer V2.0 prediction for transient receptor potential cation channel… · a predicted model of the same protein · chain A against A, TM-score 0.99
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9XSM3
- Elsewhere: RCSB PDB 7T6N · PDBe 7T6N · UniProt Q9XSM3
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