UniProt Q9GZT9
Egl nine homolog 1 (Q9GZT9)
Egl nine homolog 1 (UniProt Q9GZT9), EC 1.14.11.29: 78 experimental structures and 1 predicted model on GenesisL1, 23 ligands bound, 5 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- Q9GZT9
- Protein
- Egl nine homolog 1
- EC
- 1.14.11.29
- Experimental structures
- 78
- Predicted models
- 1
- Ligands
- 23
- Pockets
- 5 · 5 records with a druggable one
Structures
79 records of Q9GZT9 in the MolNFT archive: 78 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 2G19 | Cellular Oxygen Sensing: Crystal Structure of Hypoxia-Inducible Factor Prolyl Hydroxylase (PHD2) | x-ray diffraction | A | — | — |
| 2G19 | Cellular oxygen sensing: crystal structure of hypoxia-inducible factor prolyl hydroxylase (PHD2) | x-ray diffraction | A | — | — |
| 2G1M | Cellular Oxygen Sensing: Crystal Structure of Hypoxia-Inducible Factor Prolyl Hydroxylase (PHD2) | x-ray diffraction | A | — | — |
| 2G1M | Cellular oxygen sensing: crystal structure of hypoxia-inducible factor prolyl hydroxylase (PHD2) | x-ray diffraction | A | — | — |
| 2HBT | Crystal structure of HIF prolyl hydroxylase EGLN-1 in complex with a biologically active inhibitor | x-ray diffraction | A | — | — |
| 2HBT | Crystal structure of hif prolyl hydroxylase egln-1 in complex with a biologically active inhibitor | x-ray diffraction | A | — | — |
| 2HBU | Crystal structure of HIF prolyl hydroxylase EGLN-1 in complex with a biologically active inhibitor | x-ray diffraction | A | — | — |
| 2HBU | Crystal structure of hif prolyl hydroxylase egln-1 in complex with a biologically active inhibitor | x-ray diffraction | A | — | — |
| 2Y33 | S-nitrosylated PHD2 (GSNO soaked) in complex with Zn(II) and UN9 | x-ray diffraction | A | — | — |
| 2Y33 | S-nitrosylated PHD2 (gsno soaked) in complex with ZN(II) and UN9 | x-ray diffraction | A | — | — |
| 2Y34 | S-nitrosylated PHD2 (NO exposed) in complex with Fe(II) and UN9 | x-ray diffraction | A | — | — |
| 2Y34 | S-nitrosylated PHD2 (no exposed) in complex with FE(II) and UN9 | x-ray diffraction | A | — | — |
| 3HQR | PHD2:Mn:NOG:HIF1-alpha substrate complex | x-ray diffraction | A | — | — |
| 3HQR | PHD2:MN:NOG:HIF1-alpha substrate complex | x-ray diffraction | A | — | — |
| 3HQU | PHD2:Fe:UN9:partial HIF1-alpha substrate complex | x-ray diffraction | A | — | — |
| 3HQU | PHD2:FE:UN9:PARTIAL HIF1-alpha substrate complex | x-ray diffraction | A | — | — |
| 3OUH | PHD2-R127 with JNJ41536014 | x-ray diffraction | A | — | — |
| 3OUH | PHD2-R127 with JNJ41536014 | x-ray diffraction | A | — | — |
| 3OUI | PHD2-R717 with 40787422 | x-ray diffraction | A | — | — |
| 3OUI | PHD2-R717 with 40787422 | x-ray diffraction | A | — | — |
| 3OUJ | PHD2 with 2-Oxoglutarate | x-ray diffraction | A | — | — |
| 3OUJ | PHD2 with 2-oxoglutarate | x-ray diffraction | A | — | — |
| 4BQW | HIF prolyl hydroxylase 2 (PHD2/ EGLN1) in complex with Mn(II) and… | x-ray diffraction | A | — | — |
| 4BQW | Hif prolyl hydroxylase 2 (PHD2/ EGLN1) in complex with MN(II) and 2… | x-ray diffraction | A | — | — |
| 4BQX | HIF prolyl hydroxylase 2 (PHD2/ EGLN1) in complex with Mn(II) and… | x-ray diffraction | A | — | — |
| 4BQX | Hif prolyl hydroxylase 2 (PHD2/ EGLN1) in complex with MN(II) and N… | x-ray diffraction | A | — | — |
| 4BQY | HIF prolyl hydroxylase 2 (PHD2/ EGLN1) in complex with Fe(II) and… | x-ray diffraction | A | — | — |
| 4BQY | Hif prolyl hydroxylase 2 (PHD2/ EGLN1) in complex with FE(II) and N… | x-ray diffraction | A | — | — |
| 4JZR | Structure of Prolyl Hydroxylase Domain-containing Protein (PHD) with Inhibitors | x-ray diffraction | A | — | — |
| 4JZR | Structure of prolyl hydroxylase domain-containing protein (phd) with inhibitors | x-ray diffraction | A | — | — |
| 4KBZ | Crystal Structure of Hypoxia-Inducible Factor Prolyl Hydroxylase (PHD2) with… | x-ray diffraction | A | — | — |
| 4KBZ | Crystal structure of hypoxia-inducible factor prolyl hydroxylase (PHD2) with… | x-ray diffraction | A | — | — |
| 4UWD | HIF prolyl hydroxylase 2 (PHD2/ EGLN1) D315E VARIANT in complex with Mn(II) and… | x-ray diffraction | A | — | — |
| 4UWD | Hif prolyl hydroxylase 2 (PHD2/ EGLN1) D315E variant in complex with MN(II) and… | x-ray diffraction | A | — | — |
| 5A3U | Hif prolyl hydroxylase 2 (PHD2/EGLN1) in complex with 6-(5-oxo-4-(1H… | x-ray diffraction | A, B, C | — | — |
| 5L9B | Hif prolyl hydroxylase 2 (PHD2/ EGLN1) in complex with 2-oxoglutarate (2OG) and hif-1ALPHA codd… | x-ray diffraction | A, B | MN, AKG | — |
| 5L9R | HIF prolyl hydroxylase 2 (PHD2/ EGLN1) in complex with N-oxalylglycine (NOG) | x-ray diffraction | A | MN, OGA, SO4 | — |
| 5L9R | Hif prolyl hydroxylase 2 (PHD2/ EGLN1) in complex with N-oxalylglycine (nog) | x-ray diffraction | A | MN, OGA, SO4 | — |
| 5L9V | Hif prolyl hydroxylase 2 (PHD2-R281C/P317C) cross-linked to hif-1ALPHA nodd-L397C/D412C and… | x-ray diffraction | A, B | MN, OGA | — |
| 5LA9 | HIF prolyl hydroxylase 2 (PHD2-R281C/V314C) cross-linked to HIF-1alpha NODD-L397C/D412C and… | x-ray diffraction | A, B | MN, OGA, SO4 | — |
| 5LA9 | Hif prolyl hydroxylase 2 (PHD2-R281C/V314C) cross-linked to hif-1ALPHA nodd-L397C/D412C and… | x-ray diffraction | A, B | MN, OGA, SO4 | — |
| 5LAS | HIF prolyl hydroxylase 2 (PHD2-R281C/P317C/R396T) cross-linked to HIF-1alpha NODD-L397C/D412C and… | x-ray diffraction | A, B | MN, OGA | — |
| 5LAS | Hif prolyl hydroxylase 2 (PHD2-R281C/P317C/R396T) cross-linked to hif- 1ALPHA nodd-L397C/D412C and… | x-ray diffraction | A, B | MN, OGA | — |
| 5LAT | Hif prolyl hydroxylase 2 (PHD2/EGLN1) P317R variant in complex with MN(II) and… | x-ray diffraction | A | MN, UN9, BCT | — |
| 5LB6 | HIF prolyl hydroxylase 2 (PHD2/EGLN1) R371H variant in complex with Mn(II) and… | x-ray diffraction | A | MN, UN9, SO4 | — |
| 5LB6 | Hif prolyl hydroxylase 2 (PHD2/EGLN1) R371H variant in complex with MN(II) and… | x-ray diffraction | A | MN, UN9, SO4 | — |
| 5LBB | HIF prolyl hydroxylase 2 (PHD2/EGLN1) R396T variant in complex with Mn(II) and… | x-ray diffraction | A | MN, UN9, BCT | — |
| 5LBB | Hif prolyl hydroxylase 2 (PHD2/EGLN1) R396T variant in complex with MN(II) and… | x-ray diffraction | A | MN, UN9, BCT | — |
| 5LBC | HIF prolyl hydroxylase 2 (PHD2/EGLN1) I280V/R281L/I292V variant in complex with Mn(II) and… | x-ray diffraction | A | MN, CL, UN9, SO4, BCT | — |
| 5LBC | Hif prolyl hydroxylase 2 (PHD2/EGLN1) I280V/R281L/I292V variant in complex with MN(II) and… | x-ray diffraction | A | MN, CL, UN9, SO4, BCT | — |
| 5LBE | HIF prolyl hydroxylase 2 (PHD2/EGLN1) G294E variant in complex with Mn(II) and… | x-ray diffraction | A | MN, UN9, BCT | — |
| 5LBE | Hif prolyl hydroxylase 2 (PHD2/EGLN1) G294E variant in complex with MN(II) and… | x-ray diffraction | A | MN, UN9, BCT | — |
| 5LBF | HIF prolyl hydroxylase 2 (PHD2/EGLN1) K293K/G294E variant in complex with Mn(II) and… | x-ray diffraction | A | MN, UN9, SO4, BCT | 1 (best 0.63) |
| 5LBF | Hif prolyl hydroxylase 2 (PHD2/EGLN1) K293K/G294E variant in complex with MN(II) and… | x-ray diffraction | A | MN, UN9, SO4, BCT | — |
| 5OX5 | Hif prolyl hydroxylase 2 (PHD2/ EGLN1) in complex with CCT6, a GSK1278863-related compound | x-ray diffraction | A | MN, BCT | — |
| 5OX6 | Hif prolyl hydroxylase 2 (PHD2/ EGLN1) in complex with vadadustat | x-ray diffraction | A | MN, A1Z, SO4 | — |
| 5V18 | Structure of PHD2 in complex with 1,2,4-Triazolo-[1,5-a]pyridine | x-ray diffraction | A | SO4, 8UY, FE2 | 1 (best 0.71) |
| 5V18 | Structure of PHD2 in complex with 1,2,4-triazolo-[1,5-A]PYRIDINE | x-ray diffraction | A | SO4, 8UY, FE2 | — |
| 6NMQ | Hypoxia-inducible factor (hif) prolyl hydroxylase 2 (PHD2) in complex with the carboxamide analog… | x-ray diffraction | A | FE2, KU1 | — |
| 6QGV | HIF prolyl hydroxylase 2 (PHD2/ EGLN1) in complex with a Spiro[4.5]deca inhibitor (JPHM-2-167) | x-ray diffraction | A | MN, J2H, SO4 | — |
19 records more on the page itself.
Ligands
- MN · Manganese (II) ion · in 36 records
- SO4 · Sulfate ion · in 19 records
- BCT · Bicarbonate ion · in 15 records
- UN9 · N-[(1-chloro-4-hydroxyisoquinolin-3-yl)carbonyl]glycine · in 12 records
- OGA · N-oxalylglycine · in 10 records
- CL · Chloride ion · in 4 records
- FE2 · Fe (II) ion · in 4 records
- AKG · 2-oxoglutaric acid · in 3 records
- FE · Fe (III) ion · in 3 records
- 2JP · 4-(isoquinolin-3-ylamino)-4-oxobutanoic acid · in 2 records
- 8UY · 4-([1,2,4]triazolo[1,5-a]pyridin-5-yl)benzonitrile · in 2 records
- A1Z · Vadadustat · in 2 records
- J2H · 8-[(3-methylpyridin-2-yl)methyl]-3-(4-phenylphenyl)-1-pyrimidin-2-yl-1,3,8-triazaspiro[4.5]decane-2,4-dione · in 2 records
- PW8 · 4-[(5-bromanylisoquinolin-3-yl)amino]-4-oxidanylidene-butanoic acid · in 2 records
- 48V · {[(2R)-2,3-diamino-3-oxopropyl]sulfanyl}acetic acid · in 1 record
- A1D5X · ~{tert}-butyl 4-[6-[(6-cyanopyridin-3-yl)methylcarbamoyl]-5-oxidanyl-1,7-naphthyridin-2-yl]piperazine-1-carboxylate · in 1 record
- KU1 · N-(4-oxo-1,4-dihydrocinnoline-3-carbonyl)glycine · in 1 record
- LUW · 4-oxidanyl-~{N}-[(4-phenoxyphenyl)methyl]-2-pyrazol-1-yl-pyrimidine-5-carboxamide · in 1 record
- MG · Magnesium ion · in 1 record
- PW2 · 2-[[5-(6-methoxynaphthalen-2-yl)-3-oxidanyl-pyridin-2-yl]carbonylamino]ethanoic acid · in 1 record
- PW5 · 4-[(5-bromanyl-4,6-dimethyl-pyridin-2-yl)amino]-4-oxidanylidene-butanoic acid · in 1 record
- QEE · ~{tert}-butyl 6-[5-oxidanyl-4-(1,2,3-triazol-1-yl) pyrazol-1-yl]pyridine-3-carboxylate · in 1 record
- QEQ · 2-(6-morpholin-4-ylpyrimidin-4-yl)-4-(1,2,3-triazol-1-yl)pyrazol-3-ol · in 1 record
Experiment against prediction
- 6YVT chain A against the predicted model Q9GZT9: TM-score 0.99, RMSD 0.49 Å
- 6YVT chain E against the predicted model Q9GZT9: TM-score 0.99, RMSD 0.49 Å
- 6NMQ chain A against the predicted model Q9GZT9: TM-score 0.99, RMSD 0.51 Å
- 6YVT chain F against the predicted model Q9GZT9: TM-score 0.99, RMSD 0.57 Å
- 5L9B chain B against the predicted model Q9GZT9: TM-score 0.99, RMSD 0.60 Å
- 6YVT chain B against the predicted model Q9GZT9: TM-score 0.99, RMSD 0.65 Å
- 5L9V chain A against the predicted model Q9GZT9: TM-score 0.99, RMSD 0.66 Å
- 5LAS chain A against the predicted model Q9GZT9: TM-score 0.99, RMSD 0.65 Å
- 5LAS chain A against the predicted model Q9GZT9: TM-score 0.99, RMSD 0.65 Å
- 5LA9 chain A against the predicted model Q9GZT9: TM-score 0.99, RMSD 0.64 Å
Elsewhere
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