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Ligand · PW8

PW8 · 4-[(5-bromanylisoquinolin-3-yl)amino]-4-oxidanylidene-butanoic acid

PW8, 4-[(5-bromanylisoquinolin-3-yl)amino]-4-oxidanylidene-butanoic acid (C13 H11 Br N2 O3, 323.1 g/mol), in the MolNFT structures on GenesisL1: bound in 2 records (1 PDB entry). Every binding site with its residues within 4.5 Å, the…

Component
PW8
Formula
C13 H11 Br N2 O3
Class
ligand
Structures
2
PDB entries
1

Binding sites

PW8 in 2 structures; the first of them:

  • 6YVZ · HIF prolyl hydroxylase 2 (PHD2/ EGLN1) in complex with bicyclic JLS-367 · PW8 A502 · binds ASP254, ILE256, MET299, TYR303, TYR310, HIS313, ASP315, ILE327 and 7 more
  • 6YVZ · Hif prolyl hydroxylase 2 (PHD2/ EGLN1) in complex with bicyclic jls- 367 · PW8 A502 · binds ASP254, TYR303, TYR310, HIS313, ASP315, ILE327, TYR329, LEU343 and 4 more

Residues it binds most

TYR 2, ASP 2, HIS 2, ILE 2, ALA 2, ARG 2, LEU 2, VAL 2, MET 1, TRP 1 (residue and the binding sites it lines).

Found with

  • BCT · Bicarbonate ion
  • MN · Manganese (II) ion

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