UniProt Q02127
Dihydroorotate dehydrogenase (quinone), mitochondrial (Q02127)
Dihydroorotate dehydrogenase (quinone), mitochondrial (UniProt Q02127), EC 1.3.5.2: 146 experimental structures on GenesisL1, 56 ligands bound, 71 pockets. Binding sites, pockets, druggability and 3D structures in GL1X.
- UniProt
- Q02127
- Protein
- Dihydroorotate dehydrogenase (quinone), mitochondrial
- EC
- 1.3.5.2
- Experimental structures
- 146
- Predicted models
- 0
- Ligands
- 56
- Pockets
- 71 · 16 records with a druggable one
Structures
146 records of Q02127 in the MolNFT archive: 146 experimental, 0 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1D3G | Human dihydroorotate dehydrogenase complexed with brequinar analog | x-ray diffraction | A | — | — |
| 1D3G | Human dihydroorotate dehydrogenase complexed with brequinar analog | x-ray diffraction | A | — | — |
| 1D3H | Human dihydroorotate dehydrogenase complexed with antiproliferative agent A771726 | x-ray diffraction | A | — | — |
| 1D3H | Human dihydroorotate dehydrogenase complexed with antiproliferative agent A771726 | x-ray diffraction | A | — | — |
| 2B0M | Human dihydroorotate dehydrogenase bound to a novel inhibitor | x-ray diffraction | A | — | — |
| 2B0M | Human dihydroorotate dehydrogenase bound to a novel inhibitor | x-ray diffraction | A | — | — |
| 2BXV | Dual binding mode of a novel series of DHODH inhibitors | x-ray diffraction | A | — | — |
| 2BXV | Dual binding mode of a novel series of dhodh inhibitors | x-ray diffraction | A | — | — |
| 2FPT | Dual Binding Mode of a Novel Series of DHODH inhibitors | x-ray diffraction | A | — | — |
| 2FPT | Dual binding mode of a novel series of dhodh inhibitors | x-ray diffraction | A | — | — |
| 2FPV | Dual binding mode of a novel series of DHODH inhibitors | x-ray diffraction | A | — | — |
| 2FPV | Dual binding mode of a novel series of dhodh inhibitors | x-ray diffraction | A | — | — |
| 2FPY | Dual binding mode of a novel series of DHODH inhibitors | x-ray diffraction | A | — | — |
| 2FPY | Dual binding mode of a novel series of dhodh inhibitors | x-ray diffraction | A | — | — |
| 2FQI | dual binding modes of a novel series of DHODH inhibitors | x-ray diffraction | A | — | — |
| 2FQI | Dual binding modes of a novel series of dhodh inhibitors | x-ray diffraction | A | — | — |
| 2PRH | The structures of apo- and inhibitor bound human dihydroorotate dehydrogenase reveal conformational… | x-ray diffraction | A | — | — |
| 2PRH | The structures of apo- and inhibitor bound human dihydroorotate dehydrogenase reveal conformational… | x-ray diffraction | A | — | — |
| 2PRL | The structures of apo- and inhibitor bound human dihydroorotate dehydrogenase reveal conformational… | x-ray diffraction | A | — | — |
| 2PRL | The structures of apo- and inhibitor bound human dihydroorotate dehydrogenase reveal conformational… | x-ray diffraction | A | — | — |
| 2PRM | The structures of apo- and inhibitor bound human dihydroorotate dehydrogenase reveal conformational… | x-ray diffraction | A | — | — |
| 2PRM | The structures of apo- and inhibitor bound human dihydroorotate dehydrogenase reveal conformational… | x-ray diffraction | A | — | — |
| 2WV8 | Complex of human dihydroorotate dehydrogenase with the inhibitor 221290 | x-ray diffraction | A | — | — |
| 2WV8 | Complex of human dihydroorotate dehydrogenase with the inhibitor 221290 | x-ray diffraction | A | — | — |
| 3F1Q | Human dihydroorotate dehydrogenase in complex with a leflunomide derivative inhibitor 1 | x-ray diffraction | A | — | — |
| 3F1Q | Human dihydroorotate dehydrogenase in complex with a leflunomide derivative inhibitor 1 | x-ray diffraction | A | — | — |
| 3FJ6 | Human dihydroorotate dehydrogenase in complex with a leflunomide derivative inhibitor 2 | x-ray diffraction | A | — | — |
| 3FJ6 | Human dihydroorotate dehydrogenase in complex with a leflunomide derivative inhibitor 2 | x-ray diffraction | A | — | — |
| 3FJL | Human dihydroorotate dehydrogenase in complex with a leflunomide derivative inhibitor 3 | x-ray diffraction | A | — | — |
| 3FJL | Human dihydroorotate dehydrogenase in complex with a leflunomide derivative inhibitor 3 | x-ray diffraction | A | — | — |
| 3G0U | Human dihydroorotate dehydrogenase in complex with a leflunomide derivative inhibitor 4 | x-ray diffraction | A | — | — |
| 3G0U | Human dihydroorotate dehydrogenase in complex with a leflunomide derivative inhibitor 4 | x-ray diffraction | A | — | — |
| 3G0X | Human dihydroorotate dehydrogenase in complex with a leflunomide derivative inhibitor 5 | x-ray diffraction | A | — | — |
| 3G0X | Human dihydroorotate dehydrogenase in complex with a leflunomide derivative inhibitor 5 | x-ray diffraction | A | — | — |
| 3KVJ | Crystal Structure of Human Dihydroorotate Dehydrogenase (DHODH) with Amino-Benzoic Acid Inhibitor… | x-ray diffraction | A | — | — |
| 3KVJ | Crystal structure of human dihydroorotate dehydrogenase (dhodh) with amino-benzoic acid inhibitor… | x-ray diffraction | A | — | — |
| 3KVK | Crystal structure of human dihydroorotate dehydrogenase (DHODH) with amino-benzoic acid inhibitor… | x-ray diffraction | A | — | — |
| 3KVK | Crystal structure of human dihydroorotate dehydrogenase (dhodh) with amino-benzoic acid inhibitor… | x-ray diffraction | A | — | — |
| 3KVL | Crystal structure of human dihydroorotate dehydrogenase (DHODH) with amino-benzoic acid inhibitor… | x-ray diffraction | A | — | — |
| 3KVL | Crystal structure of human dihydroorotate dehydrogenase (dhodh) with amino-benzoic acid inhibitor… | x-ray diffraction | A | — | — |
| 3KVM | Crystal structure of human dihydroorotate dehydrogenase (DHODH) with amino-benzoic acid inhibitor… | x-ray diffraction | A | — | — |
| 3KVM | Crystal structure of human dihydroorotate dehydrogenase (dhodh) with amino-benzoic acid inhibitor… | x-ray diffraction | A | — | — |
| 3U2O | Dihydroorotate Dehydrogenase (DHODH) crystal structure in complex with small molecule inhibitor | x-ray diffraction | A | — | — |
| 3U2O | Dihydroorotate dehydrogenase (dhodh) crystal structure in complex with small molecule inhibitor | x-ray diffraction | A | — | — |
| 3W7R | Structure of Human dihydroorotate dehydrogenase in complex with mii-4-097 | x-ray diffraction | A | — | — |
| 3W7R | Structure of human dihydroorotate dehydrogenase in complex with mii-4- 097 | x-ray diffraction | A | — | — |
| 3ZWS | Structure of Human Dihydroorotate Dehydrogenase with a Bound Inhibitor | x-ray diffraction | A | — | — |
| 3ZWS | Structure of human dihydroorotate dehydrogenase with a bound inhibitor | x-ray diffraction | A | — | — |
| 3ZWT | Structure of Human Dihydroorotate Dehydrogenase with a Bound Inhibitor | x-ray diffraction | A | — | — |
| 3ZWT | Structure of human dihydroorotate dehydrogenase with a bound inhibitor | x-ray diffraction | A | — | — |
| 4IGH | High resolution crystal structure of human dihydroorotate dehydrogenase bound with 4-quinoline… | x-ray diffraction | A | — | — |
| 4IGH | High resolution crystal structure of human dihydroorotate dehydrogenase bound with 4-quinoline… | x-ray diffraction | A | — | — |
| 4JGD | Crystal structure of human dihydroorotate dehydrogenase (DHODH) with DH03A016 | x-ray diffraction | A | — | — |
| 4JGD | Crystal structure of human dihydroorotate dehydrogenase (dhodh) with DH03A016 | x-ray diffraction | A | — | — |
| 4JS3 | Crystal structure of human dihydroorotate dehydrogenase (DHODH) with 057 | x-ray diffraction | A | — | — |
| 4JS3 | Crystal structure of human dihydroorotate dehydrogenase (dhodh) with 057 | x-ray diffraction | A | — | — |
| 4JTS | Crystal structure of human dihydroorotate dehydrogenase (DHODH) with 072 | x-ray diffraction | A | — | — |
| 4JTS | Crystal structure of human dihydroorotate dehydrogenase (dhodh) with 072 | x-ray diffraction | A | — | — |
| 4JTT | Crystal structure of human dihydroorotate dehydrogenase (DHODH) with 066 | x-ray diffraction | A | — | — |
| 4JTT | Crystal structure of human dihydroorotate dehydrogenase (dhodh) with 066 | x-ray diffraction | A | — | — |
86 records more on the page itself.
Ligands
- FMN · Flavin mononucleotide · in 53 records
- ORO · Orotic acid · in 52 records
- SO4 · Sulfate ion · in 44 records
- CL · Chloride ion · in 21 records
- NA · Sodium ion · in 7 records
- DDQ · Decylamine-N,N-dimethyl-N-oxide · in 6 records
- DOR · (4S)-2,6-dioxohexahydropyrimidine-4-carboxylic acid · in 4 records
- FNR · 1-deoxy-1-(7,8-dimethyl-2,4-dioxo-3,4-dihydro-2H-benzo[g]pteridin-1-id-10(5H)-yl)-5-O-phosphonato-D-ribitol · in 4 records
- 9BL · methyl (2E,6E)-8-(3-chloro-5-formyl-2,6-dihydroxy-4-methylphenyl)-2,6-dimethylocta-2,6-dienoate · in 2 records
- 9BU · (2E,6E)-8-(3-chloro-5-formyl-2,6-dihydroxy-4-methylphenyl)-3,6-dimethylocta-2,6-dien-1-yl 2-methylpropanoate · in 2 records
- B5O · (6R)-1-[3,5-bis(fluoranyl)-4-[2-fluoranyl-5-(hydroxymethyl)phenyl]phenyl]-6-propan-2-yl-6,7-dihydro-5H-benzotriazol-4-one · in 2 records
- B6R · 3-[3,5-bis(fluoranyl)-4-(3-methoxyphenyl) phenyl]benzo[f]benzotriazole-4,9-dione · in 2 records
- CE9 · Dodecyl nona ethylene glycol ether · in 2 records
- DET · Undecylamine-N,N-dimethyl-N-oxide · in 2 records
- DUH · 2-oxidanyl-~{N}-[2,3,5,6-tetrakis(fluoranyl)-4-phenyl-phenyl]pyrazolo[1,5-a]pyridine-3-carboxamide · in 2 records
- F1W · 4-~{tert}-butyl-~{N}-[[4-[5-(dimethylamino) pentanoylamino]phenyl]carbamothioyl]benzamide · in 2 records
- HYT · 2-methyl-5-oxidanyl-~{N}-[2,3,5,6-tetrakis(fluoranyl)-4-phenyl-phenyl]-1,2,3-triazole-4-carboxamide · in 2 records
- MLJ · ~{N}-[3-oxidanylidene-3-[[(1~{R})-1,2,3,4-tetrahydronaphthalen-1-yl]amino]propyl]-4-(trifluoromethyloxy)benzamide · in 2 records
- R4P · 1-methyl-5-(2'-methyl[1,1'-biphenyl]-4-yl)-1H-benzotriazole-7-carboxylic acid · in 2 records
- SDV · N-[(4R)-1-(2-fluorophenyl)-4,5,6,7-tetrahydroindazol-4-yl]-2,1-benzoxazole-3-carboxamide · in 2 records
- T78 · (6M)-N-(2-chloro-4-methylpyridin-3-yl)-6-[4-ethyl-3-(hydroxymethyl)-5-oxo-4,5-dihydro-1H-1,2,4-triazol-1-yl]-5-fluoro-2-{[(2S)-1,1,1-trifluoropropan-2-yl]oxy}pyridine-3-carboxamide · in 2 records
- TMK · (6M)-N-(3-chloro-2-methoxy-5-methylpyridin-4-yl)-6-[4-ethyl-3-(hydroxymethyl)-5-oxo-4,5-dihydro-1H-1,2,4-triazol-1-yl]-5-fluoro-2-{[(2S)-1,1,1-trifluoropropan-2-yl]oxy}pyridine-3-carboxamide · in 2 records
- U91 · 1,5-dimethyl-3-oxidanyl-~{N}-[2,3,5,6-tetrakis(fluoranyl)-4-phenyl-phenyl]pyrazole-4-carboxamide · in 2 records
- ZWI · 3-[decyl(dimethyl)ammonio]propane-1-sulfonate · in 2 records
- 1SU · N-{7-cyano-6-[4-fluoro-3-({[3-(trifluoromethyl) phenyl]acetyl}amino)phenoxy]-1,3-benzothiazol-2-yl}cyclopropanecarboxamide · in 1 record
- 4R5 · 1-(3,5-difluoro-3'-methoxybiphenyl-4-yl)-3-(1,3-thiazol-5-yl)urea · in 1 record
- 64B · methyl (2Z)-cyano[3-(2-fluoro-4-methoxyphenyl)-4-oxo-1,3-thiazolidin-2-ylidene]acetate · in 1 record
- 7GF · methyl (2Z)-3-azanyl-2-[3-(4-bromophenyl)-4-oxidanylidene-1,3-thiazolidin-2-ylidene]propanoate · in 1 record
- 7L7 · methyl (2~{Z})-2-cyano-2-[3-(2-fluorophenyl)-4-oxidanylidene-1,3-thiazolidin-2-ylidene]ethanoate · in 1 record
- 9AU · 4-oxidanyl-3-[(2~{E},6~{E})-3,7,11-trimethyldodeca-2,6, 10-trienyl]chromen-2-one · in 1 record
Elsewhere
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