ORO · Orotic acid

Binding sites

ORO in 99 structures; the first of them:

• 4ZMG · Crystal structure of Human Dihydroorotate Dehydrogenase (DHODH) with DH03A338 · ORO A402 · binds LYS100, ASN145, ARG146, TYR147, GLY148, PHE149, ASN212, SER215 and 4 more
• 5BOO · Crystal structure of Plasmodium falciparum dihydroorotate dehydrogenase bound with… · ORO A1003 · binds LYS229, ASN274, CYS276, GLY277, PHE278, ASN279, ASN342, SER344 and 5 more
• 5DEL · Crystal structure of Plasmodium falciparum dihydroorotate dehydrogenase bound with… · ORO A602 · binds LYS229, ASN274, SER275, CYS276, GLY277, PHE278, ASN342, SER345 and 4 more
• 5FI8 · Crystal structure of plasmodium falciparum dihydroorotate dehydrogenase bounded with… · ORO A1003 · binds LYS229, ASN274, SER275, CYS276, GLY277, PHE278, ASN342, ASN458 and 1 more
• 5H2Z · Crystal structure of Human Dihydroorotate Dehydrogenase (DHODH) with 7GF · ORO A402 · binds LYS100, ASN145, ARG146, TYR147, GLY148, PHE149, ASN212, SER215 and 4 more
• 5H73 · Crystal structure of human DHODH with 18F · ORO A403 · binds LYS100, ASN145, ARG146, TYR147, GLY148, PHE149, ASN150, ASN212 and 5 more
• 5HQE · Crystal structure of human dihydroorotate dehydrogenase (DHODH) with compound 18T · ORO A403 · binds LYS100, ASN145, TYR147, GLY148, PHE149, ASN212, SER215, PRO216 and 3 more
• 5K9C · Crystal structure of human dihydroorotate dehydrogenase with ML390 · ORO A401 · binds LYS100, ASN145, ARG146, TYR147, GLY148, PHE149, ASN150, ASN212 and 5 more
• 5K9D · Crystal structure of human dihydroorotate dehydrogenase at 1.7 A resolution · ORO A401 · binds LYS100, ASN145, ARG146, TYR147, GLY148, PHE149, ASN150, ASN212 and 5 more
• 5MUT · Crystal structure of potent human Dihydroorotate Dehydrogenase inhibitors based on… · ORO A402 · binds LYS100, ASN145, ARG146, TYR147, GLY148, PHE149, ASN212, ASN284 and 1 more
• 5MVC · Crystal structure of potent human Dihydroorotate Dehydrogenase inhibitors based on… · ORO A402 · binds LYS100, ASN145, ARG146, TYR147, GLY148, PHE149, ASN212, SER215 and 3 more
• 5MVD · Crystal structure of potent human Dihydroorotate Dehydrogenase inhibitors based on… · ORO A402 · binds LYS100, ASN145, ARG146, TYR147, GLY148, PHE149, ASN150, ASN212 and 4 more
• 5UE9 · WT DHODB with orotate bound · ORO A402 · binds LYS48, ASN72, ALA73, ILE74, GLY75, LEU76, ASN132, SER134 and 3 more
• 5ZF4 · Structure of human dihydroorotate dehydrogenase in complex with 275-10-COOMe · ORO A402 · binds LYS100, ASN145, ARG146, TYR147, GLY148, PHE149, ASN212, SER215 and 4 more
• 5ZFA · Structure of human dihydroorotate dehydrogenase in complex with 287-12-OCOiPr · ORO A402 · binds LYS100, ASN145, ARG146, TYR147, GLY148, PHE149, ASN212, SER215 and 3 more
• 6AJE · Crystal structure of DHODH in complex with ferulenol from Eimeria tenella · ORO A502 · binds LYS67, THR87, ASN112, ARG113, CYS114, GLY115, PHE116, ASN117 and 7 more
• 6E0B · Plasmodium falciparum dihydroorotate dehydrogenase C276F mutant bound with… · ORO A1003 · binds LYS229, ASN274, SER275, PHE276, GLY277, PHE278, ASN342, SER345 and 4 more
• 6EBS · Crystal structure of Leishmania major dihydroorotate dehydrogenase mutant H174A in… · ORO A402 · binds LYS44, ASN68, SER69, MET70, GLY71, LEU72, PRO73, ASN128 and 6 more
• 6FMD · Targeting myeloid differentiation using potent human dihydroorotate dehydrogenase… · ORO A411 · binds LYS100, ASN145, ARG146, TYR147, GLY148, PHE149, ASN212, ASN284 and 1 more
• 6GJG · Plasmodium falciparum dihydroorotate dehydrogenase DHODH in complex with… · ORO A602 · binds LYS229, ASN274, CYS276, GLY277, PHE278, ASN342, SER345, PRO346 and 3 more
• 6I55 · Plasmodium falciparum dihydroorotate dehydrogenase (DHODH) co-crystallized with… · ORO A602 · binds LYS229, ASN274, CYS276, GLY277, PHE278, ASN342, SER345, PRO346 and 3 more
• 6J3B · Crystal structure of human DHODH in complex with inhibitor 1289 · ORO A404 · binds LYS100, ASN145, ARG146, TYR147, GLY148, PHE149, ASN212, SER215 and 3 more
• 6LP7 · Crystal structure of human DHODH in complex with inhibitor 0944 · ORO A402 · binds LYS100, ASN145, ARG146, TYR147, GLY148, PHE149, ASN212, SER215 and 4 more
• 6OC0 · Crystal structure of human DHODH with OSU-03012 · ORO A401 · binds LYS99, ASN144, ARG145, TYR146, GLY147, PHE148, ASN211, SER214 and 4 more
• 6OC1 · Crystal structure of human DHODH with TAK-632 · ORO A401 · binds LYS99, SER119, ASN144, ARG145, TYR146, GLY147, PHE148, ASN211 and 5 more
• 6TAJ · Crystal structure of Escherichia coli Orotate Phosphoribosyltransferase in complex with… · ORO AAA301 · binds LEU25, LYS26, PHE34, PHE35, VAL126, THR128, ARG156
• 6TAK · Crystal structure of Escherichia coli Orotate Phosphoribosyltransferase in complex with… · ORO AAA301 · binds LEU25, LYS26, PHE34, PHE35, ASP125, VAL126, THR128, ARG156
• 6VND · Quaternary Complex of human dihydroorotate dehydrogenase (DHODH) with flavin… · ORO A411 · binds LYS99, ASN144, ARG145, TYR146, GLY147, PHE148, ASN211, SER214 and 4 more
• 6VTY · Crystal structure of Plasmodium falciparum dihydroorotate dehydrogenase bound with… · ORO A1003 · binds LYS229, ASN274, SER275, CYS276, GLY277, PHE278, ASN342, SER345 and 4 more

Residues it binds most

ASN 148, SER 131, THR 148, GLY 148, PHE 144, LYS 136, PRO 114, ARG 73, CYS 70, TYR 58 (residue and the binding sites it lines).

Found with

• FMN · Flavin mononucleotide
• ACT · Acetate ion
• SO4 · Sulfate ion
• GOL · Glycerol
• CL · Chloride ion
• LDA · Lauryl dimethylamine-N-oxide
• NA · Sodium ion
• FNR · 1-deoxy-1-(7,8-dimethyl-2,4-dioxo-3,4-dihydro-2H-benzo[g]pteridin-1-id-10(5H)-yl)-5-O-phosphonato-D-ribitol
• PO4 · Phosphate ion
• PGE · Triethylene glycol
• 9AU · 4-oxidanyl-3-[(2~{E},6~{E})-3,7,11-trimethyldodeca-2,6, 10-trienyl]chromen-2-one
• 1SU · N-{7-cyano-6-[4-fluoro-3-({[3-(trifluoromethyl) phenyl]acetyl}amino)phenoxy]-1,3-benzothiazol-2-yl}cyclopropanecarboxamide